Nimotop (10mg) 50ml, 1 Vial Injection

Nimodipine, a potent and highly selective calcium channel blocker, exerts its therapeutic effects primarily by inhibiting the influx of calcium ions into smooth muscle cells and neurons. This mechanism is crucial as it leads to smooth muscle relaxation, particularly in the walls of cerebral blood vessels. By blocking L-type calcium channels, nimodipine reduces calcium-induced vasoconstriction, thereby promoting vasodilation in the cerebral arteries and enhancing blood flow to the brain. The relaxation of these blood vessels is essential in maintaining cerebral perfusion and preventing vasospasm, which is a significant concern in certain neurological conditions.

Calcium channel blocker.

Injection

The following are the uses of Nimodipine 10mg injection:

• Used for treating subarachnoid haemorrhage, reducing the risk of further bleeding and protecting the brain.
• Used for managing cerebral vasospasm, relaxing blood vessels and improving blood flow.
• Used to prevent strokes and neurological damage caused by reduced blood flow to the brain.
• Used to treat high blood pressure in the brain, helping to lower and regulate intracranial pressure.
• Used in cases of cerebral ischemia, restoring oxygen and nutrient supply to brain tissue.
• Used to alleviate headaches and migraines associated with brain blood vessel issues.
• Used to enhance recovery and reduce complications in brain injury patients.

In the case of an overdose of Nimodipine 10mg injection, it is important to act promptly. Symptoms may include severe hypotension, bradycardia, and cardiac arrhythmias. Medical intervention is necessary, and patients should be closely monitored for any signs of toxicity. Treatment may involve supportive care, such as maintaining blood pressure and cardiac function, and may require hospitalization for further evaluation and management. Quick action can help mitigate the potential severe consequences of an overdose.

In the case of a missed dose of Nimodipine 10mg injection, it is important to act promptly. If you remember within a few hours of the missed dose, administer the injection as soon as possible. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. Consult your healthcare professional if you have any concerns or if you miss multiple doses.

To administer Nimodipine 10mg injection, draw the medication into a syringe, ensuring it is free of air bubbles, and inject it slowly into the vein over a period of 30-60 seconds, following the prescribed dosage and administration guidelines provided by your healthcare professional.

Here are the conditions or situations when Nimodipine 10mg injection should not be administered:

• Should not be used in patients with a known allergy or hypersensitivity to Nimodipine or other calcium channel blockers.
• Contraindicated in patients with severe hypotension (very low blood pressure).
• Not recommended for individuals with aortic stenosis (narrowing of the aortic valve in the heart).
• Should not be used in patients with cardiogenic shock (shock caused by heart dysfunction).
• Contraindicated during breastfeeding, as it may pass into breast milk and harm the nursing infant.
• Not suitable for patients with severe liver disease or impaired liver function.
• Should be avoided in patients with acute myocardial infarction (heart attack) or unstable angina.
• Not recommended for individuals with cerebral edema (swelling of the brain) due to head trauma.

The side effects of Nimodipine 10mg injection may include:

• Dizziness or lightheadedness
• Headache
• Nausea and vomiting
• Flushing (warmth or redness in the face)
• Slow heart rate (bradycardia)
• Low blood pressure (hypotension)
• Constipation
• Increased liver enzymes

Following are the precautions and warnings:

• Nimodipine 10mg injection should not be administered to individuals with a known hypersensitivity or allergy to nimodipine or any other dihydropyridine calcium channel blockers.
• This medication is intended for intravenous use only and should be administered with caution to prevent extravasation, which can cause severe tissue damage.
• Close monitoring of blood pressure is essential during treatment, especially in patients with hypertension or hypotension, as nimodipine can cause significant blood pressure changes.
• Caution is advised in patients with liver disease as nimodipine is extensively metabolized in the liver, and dosage adjustments may be required.
• Nimodipine may cause fluid retention, so patients with heart failure or other cardiovascular conditions should be carefully monitored.
• It may interact with other medications, including beta-blockers, antihypertensives, and CYP3A4 inhibitors, so healthcare professionals should review all medications the patient is taking.
• Not recommended for use in pregnant or breastfeeding women unless the potential benefits outweigh the risks; it should be used during pregnancy only if clearly needed.
• Store the injection at room temperature, away from direct sunlight, and do not freeze; protect from physical damage.

Following are the drug interactions for Nimodipine 10mg Injection:

• Nimodipine may interact with CYP3A4 inducers (e.g., rifampin, carbamazepine) which can decrease its effectiveness.
• Using it with CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) may increase Nimodipine levels, potentially leading to adverse effects.
• Combining Nimodipine with other calcium channel blockers or antihypertensive drugs can result in excessive blood pressure reduction.
• The risk of bleeding may increase when used with anticoagulants or antiplatelet drugs, such as warfarin or clopidogrel.
• Nimodipine can enhance the hypotensive effects of general anesthetics, requiring close monitoring during surgical procedures.
• It may interact with beta-blockers, potentially causing additive effects on heart rate and blood pressure.
• Concomitant use with digoxin may increase digoxin levels, requiring careful monitoring of digoxin concentrations.

Following are the food interactions for Nimodipine 10mg injection:

• Avoid consuming grapefruit or grapefruit juice as they may increase the blood levels of Nimodipine, potentially leading to increased side effects.
• Alcohol consumption should be minimized as it can cause excessive drowsiness or dizziness when combined with Nimodipine.
• Caffeine intake should be monitored as it may reduce the effectiveness of Nimodipine by constricting blood vessels.
• Avoid high-fat meals as they can delay the absorption of Nimodipine, affecting its therapeutic action.
• Certain citrus fruits like Seville oranges may interfere with Nimodipine metabolism, so monitor intake.
• Avoid natural licorice as it can increase blood pressure, counteracting the effects of Nimodipine.
• Be cautious with herbal supplements like St. John's Wort, as they may interact with Nimodipine's metabolism.
• Always consult a healthcare professional for personalized advice regarding dietary restrictions and interactions.

Nimodipine 10mg injection should be stored in a controlled environment, specifically at room temperature between 15°C and 30°C (59°F and 86°F). Protect the injection from light and keep it in its original packaging to maintain its integrity. It is crucial to store this medication away from children and pets to prevent accidental exposure. Do not freeze Nimodipine 10mg injection as it may affect its potency. When disposing of unused or expired medication, do not throw it into the trash or pour it down the drain. Instead, follow local guidelines for pharmaceutical waste disposal or consult a pharmacist for safe disposal options to minimize environmental impact.

Following are the quick tips for Nimodipine 10mg Injection:

• Administer the injection under medical supervision for safe and effective use.
• Ensure the injection is given at the correct site and with proper technique.
• Check the expiry date before use, and discard if expired.
• Store the injection at room temperature, away from direct sunlight and moisture.
• Do not freeze the medication, as it may affect its potency.
• Inform your doctor if you have any allergies or medical conditions before receiving the injection.
• Report any unusual symptoms or side effects to your healthcare provider immediately.