Nipsso MR 500+200mg tab 28s

Naproxen and Esomeprazole are combined in a single tablet to provide both pain relief and gastric protection. Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), primarily works by inhibiting cyclooxygenase (COX) enzymes, particularly COX-2. This inhibition reduces the production of prostaglandins, which are mediators of inflammation and pain. By blocking these enzymes, naproxen helps alleviate pain, inflammation, and fever associated with various conditions. Esomeprazole, a proton pump inhibitor (PPI), acts by specifically targeting gastric proton pumps, which are responsible for acid secretion in the stomach. It irreversibly binds to and inhibits the H+/K+-ATPase enzyme within the gastric parietal cells, suppressing gastric acid secretion. This mechanism helps protect the stomach lining and reduces the risk of gastrointestinal side effects that can be associated with naproxen use, such as gastric ulcers or erosions.

NSAID, Proton Pump Inhibitor.

Tablet

The following are the uses of Naproxen, Esomeprazole Tablet:

• Used for relieving acute pain, inflammation, and stiffness caused by conditions like arthritis, gout, or injuries.
• Used for reducing fever and managing pain from conditions such as headaches, toothaches, or menstrual cramps.
• Used for treating chronic pain and inflammation associated with rheumatoid arthritis and osteoarthritis.
• Used for preventing and managing gastric ulcers and erosions caused by nonsteroidal anti-inflammatory drugs (NSAIDs).
• Used for improving overall pain management and reducing the risk of stomach-related side effects in patients requiring long-term NSAID therapy.
• Used for providing symptomatic relief in conditions with pain and inflammation, such as ankylosing spondylitis and juvenile rheumatoid arthritis.
• Used for managing acute pain and inflammation following dental procedures or minor surgeries.

In the case of an overdose of Naproxen and Esomeprazole Tablets, individuals may experience symptoms such as stomach pain, nausea, vomiting, dizziness, or drowsiness. In more severe cases, rapid or troubled breathing, severe headache, confusion, and even loss of consciousness can occur. Immediate medical assistance is necessary to manage the situation effectively, and healthcare professionals should be informed about the suspected overdose to provide appropriate treatment and support.

In the case of a missed dose of Naproxen, it is recommended to take the missed dose as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. For Esomeprazole, if you miss a dose, take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular dosing regimen. It's important not to take extra medication to compensate for a missed dose.

To take Naproxen and Esomeprazole Tablets, swallow the tablet whole with a full glass of water, preferably in the morning before a meal, following the dosage instructions provided by your healthcare professional, which may include a prescription for once-daily use.

Following are the conditions/situations when Naproxen and Esomeprazole Tablet should not be used:

• Avoid using this medication if you have a known allergy to Naproxen, Esomeprazole, or any other NSAIDs (Non-Steroidal Anti-Inflammatory Drugs).
• Do not take this medication if you have a history of severe allergic reactions, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat.
• Contraindicated in individuals with a history of asthma, severe kidney disease, or liver impairment caused by Naproxen or Esomeprazole.
• Should not be used in patients with a history of gastrointestinal bleeding or perforation associated with previous NSAID use.
• Not recommended for individuals with active stomach ulcers or bleeding disorders.
• Avoid using this medication if you have recently undergone heart surgery.
• Do not take this medication if you have a history of heart attack, stroke, or blood clotting disorders.
• Contraindicated in patients with severe dehydration or low blood sodium levels (hyponatremia).
• Should not be used in individuals with a history of esophageal or stomach varices (enlarged veins).

The side effects of Naproxen, Esomeprazole Tablet may include:

• Stomach pain or discomfort
• Nausea and vomiting
• Diarrhea or constipation
• Headache or dizziness
• Skin rash or itching
• Fatigue or drowsiness
• Increased blood pressure
• Difficulty breathing or swallowing

Following are the precautions and warnings for Naproxen, Esomeprazole Tablet:

• Avoid using this medication if you are allergic to non-steroidal anti-inflammatory drugs (NSAIDs) or have a history of severe allergic reactions to aspirin or other pain relievers.
• Consult your doctor if you have a history of gastrointestinal bleeding, ulcers, or other stomach disorders before taking this medication.
• This medication may increase the risk of cardiovascular events such as heart attack or stroke. Individuals with known heart disease should use it with caution.
• It is recommended to monitor blood pressure regularly during long-term use, especially in patients with hypertension.
• Naproxen, Esomeprazole Tablet may cause liver enzyme elevations. Regular monitoring of liver function is advised, particularly in patients with pre-existing liver conditions.
• Elderly patients may be more susceptible to side effects, especially gastrointestinal bleeding and kidney problems.
• Pregnant and breastfeeding women should consult their healthcare provider before using this medication, as it may have potential risks for the fetus and infant.

Following are the drug interactions for Naproxen, Esomeprazole Tablet:

• Concurrent use with other non-steroidal anti-inflammatory drugs (NSAIDs) or aspirin may increase the risk of gastrointestinal bleeding and ulcers.
• Naproxen can reduce the effectiveness of antihypertensive medications, such as beta-blockers and ACE inhibitors.
• Esomeprazole may decrease the absorption of drugs that require an acidic environment, like ketoconazole and atazanavir.
• The effects of anticoagulants, such as warfarin, may be enhanced, increasing the risk of bleeding.
• Naproxen can increase serum lithium levels, requiring monitoring of lithium levels during concurrent use.
• Methotrexate levels may be elevated when used with Naproxen, potentially increasing toxicity.
• Probenecid can decrease the excretion of Naproxen, leading to increased plasma levels and potential toxicity.

Following are the food interactions for Naproxen, Esomeprazole Tablet:

• Alcohol consumption should be avoided as it may increase the risk of gastrointestinal bleeding, especially when used with Naproxen.
• Grapefruit and grapefruit juice should be consumed with caution as they can inhibit certain enzymes, potentially affecting the metabolism of Esomeprazole.
• High-fat meals can delay the absorption of Esomeprazole, leading to a potential decrease in its effectiveness.
• Avoid excessive caffeine intake, as it may increase the risk of stomach irritation and interfere with the healing process of the esophagus.
• Spicy foods should be consumed in moderation as they can irritate the stomach and potentially worsen symptoms, especially in individuals with a history of stomach ulcers.
• Dairy products may reduce the absorption of Esomeprazole, so it is advisable to separate them by a few hours when taking this medication.
• Avoid large amounts of salty foods as they can increase the risk of fluid retention and elevate blood pressure.
• Foods rich in vitamin K, like leafy greens, should be consumed consistently as Naproxen may interfere with blood clotting, and vitamin K is essential for this process.

Naproxen and Esomeprazole Tablets should be stored in a cool, dry place, preferably at room temperature, and away from direct exposure to sunlight or moisture. The medication bottle should be tightly sealed to maintain its integrity and effectiveness. It is crucial not to store the tablets in the bathroom or near any heat-emitting appliances, as high temperatures can degrade the medication. Proper disposal of unused or expired tablets is essential; do not flush them down the toilet or pour them into drainage systems. Consult your pharmacist or healthcare professional for appropriate disposal methods in your area. Keep the medication securely stored, out of reach of children, to prevent accidental consumption.

Following are the quick tips for Naproxen, Esomeprazole Tablet:

• Consult your doctor before use, especially if you have a history of heart disease, hypertension, or stomach problems.
• Take the tablet with a full glass of water, preferably with food to reduce stomach irritation.
• Avoid alcohol consumption while using this medication to prevent increased risk of stomach bleeding.
• Do not crush or chew the tablet; swallow it whole for effective absorption.
• Be cautious if you're taking other medications, as Naproxen can interact with several drugs.
• Inform your doctor if you experience any unusual bleeding, black stools, or persistent stomach pain.
• Store the medication at room temperature, away from moisture and light.