NISYLEN 30ML DROP (WS)

The primary mechanism of action of Aconitum, as found in Aconitum Drops, involves the binding of specific alkaloids to various receptors and ion channels in the body, particularly in the cardiovascular and nervous systems. The main alkaloid, aconitine, acts as a potent neurotoxin and affects the voltage-gated sodium channels in cell membranes. It alters the permeability of these channels, leading to a modification in the cell's ability to generate and transmit electrical signals. This disruption can result in both excitatory and inhibitory effects on the central and peripheral nervous systems. Aconitum can also interact with receptors in the heart, causing an increase in cardiac contractility and heart rate, which may lead to its therapeutic use in certain cardiovascular conditions. The plant's compounds may further influence the regulation of blood pressure and exhibit diuretic properties, contributing to its historical use in treating various ailments related to the circulatory system.

Aconitum

Antitussive expectorant

Drop

The following are the uses of Aconitum Drop:

• Used for treating acute and intense inflammatory conditions, especially in the early stages.
• Used for rapid onset of fever, especially with a sudden high temperature.
• Used for intense, sharp, and stabbing pain, often described as 'lightning-like' or 'knife-like'.
• Used for treating respiratory conditions like asthma and bronchitis, where there is a feeling of constriction and difficulty in breathing.
• Used for skin conditions with intense itching, burning, and redness, such as hives or eczema.
• Used for conditions with a rapid and violent onset, such as acute rheumatism or gout.
• Used for psychological conditions characterized by intense fear, anxiety, and panic attacks.
• Used for treating shock and collapse, especially with a rapid and weak pulse.

In the case of an overdose of Aconitum Drops, it is crucial to recognize the signs, which may include severe nausea, vomiting, and a burning sensation in the mouth. Prompt action is vital; contact a healthcare professional or poison control center immediately. They will provide specific guidance for managing the overdose, which may include inducing vomiting or administering activated charcoal to minimize absorption. Quick response and expert advice are essential to ensure the best possible outcome.

In the case of a missed dose of Aconitum Drops, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may lead to potential side effects. If you miss multiple doses, consult your healthcare provider for guidance on how to safely adjust your dosage and get back on track with your treatment plan.

To take Aconitum Drops, place the prescribed number of drops under your tongue, holding them there for approximately 30 seconds to 1 minute before swallowing, preferably on an empty stomach or as directed by your healthcare professional.

Following are the conditions or situations when Aconitum Drop should not be used:

• Allergic reactions • Do not use if you have a known allergy or sensitivity to Aconitum napellus or other related plants.
• Pregnancy and breastfeeding • Avoid using Aconitum drops during pregnancy and while breastfeeding, as the safety is not established.
• Children • Not recommended for children due to potential toxicity and lack of established dosage guidelines.
• Heart conditions • Contraindicated in individuals with severe heart diseases or arrhythmias, as it may worsen the condition.
• High blood pressure • Should not be used in individuals with uncontrolled hypertension.
• Neurological disorders • Avoid using if you have epilepsy or other seizure disorders, as it may lower the seizure threshold.
• Liver or kidney problems • Not recommended for those with impaired liver or kidney function, as it may affect the metabolism and elimination of the medication.
• Surgery • Discontinue use before any surgical procedures, including dental surgery, as it may interfere with anesthesia.
• Individual intolerance • If you experience any unusual symptoms or side effects after taking Aconitum drops, stop using it and consult a healthcare professional.

The side effects of Aconitum Drop may include:

• Nausea and vomiting
• Dizziness or lightheadedness
• Skin reactions such as rashes or itching
• Dry mouth
• Increased heart rate or palpitations
• Confusion and disorientation
• Weakness and muscle pain
• Difficulty in breathing

Following are the precautions and warnings for Aconitum Drop:

• Do not use if you are allergic to any of the ingredients in the drop, including Aconitum Napellus.
• This medication should be used with caution in patients with heart disease, as it can affect heart rate and rhythm.
• Avoid driving or operating heavy machinery until you know how the medication affects you, as it may cause dizziness or drowsiness.
• Aconitum Drop should be used with caution in elderly patients due to increased sensitivity.
• Do not exceed the recommended dosage, as it may lead to severe side effects.
• Keep out of reach of children. Accidental ingestion can be highly dangerous.
• Consult a healthcare professional if you have any underlying medical conditions or are taking other medications.

Following are the drug interactions for Aconitum Drop:

• Aconitum Drop should not be used concurrently with other medications that contain aconitum or aconite, as it may lead to increased toxicity.
• It may interact with beta-blockers, affecting heart rate and blood pressure.
• Drugs that affect the central nervous system, such as opioids and benzodiazepines, can have additive effects when combined with Aconitum Drop.
• Antipsychotic medications may interact, potentially causing increased side effects and altered mental status.
• Concomitant use with diuretics might lead to electrolyte imbalances and increased risk of cardiac arrhythmias.
• Avoid using Aconitum Drop with other herbal remedies that have similar effects, such as belladonna or strychnine, due to potential additive toxicity.
• Consult a healthcare professional before combining Aconitum Drop with any other medications, especially those affecting the heart or nervous system.

Following are the food interactions to be aware of when taking Aconitum Drops:

• Avoid consuming grapefruit and grapefruit juice as they may influence the metabolism of certain compounds in the drops, potentially affecting their effectiveness.
• Alcohol consumption should be avoided as it can increase the sedative effects and may lead to heightened drowsiness and dizziness.
• Caffeine-rich beverages like coffee and energy drinks should be limited as they can interfere with the calming properties of the drops.
• Spicy foods may increase the absorption rate of certain components in the drops, potentially leading to increased side effects.
• Avoid fatty meals as they can slow down the absorption of the medicine, delaying its effects.
• Do not consume dairy products simultaneously with the drops as calcium can interact with certain ingredients.
• Herbal teas and supplements should be used cautiously as some herbs may have interactions with the active compounds in Aconitum Drops.
• Always consult a healthcare professional for personalized advice regarding specific dietary considerations while using this medication.

Aconitum Drop storage and disposal should be done with caution to ensure safety. Store the drops in a cool, dry area, preferably at room temperature, and avoid exposure to direct sunlight or excessive heat. Keep the bottle tightly sealed to maintain its integrity and prevent contamination. Do not store it in the bathroom or kitchen due to the potential for temperature fluctuations and moisture. Always check the expiration date, and if the drops are past their prime, dispose of them properly by consulting a pharmacist or healthcare professional who can advise on safe disposal methods. Never pour the drops down the sink or flush them, as this may cause environmental harm. Keep the medication away from children's reach to prevent accidental ingestion.

Following are the quick tips for Aconitum Drop:

• Administer the drops as directed by your healthcare professional for best results.
• Store the drops in a cool, dry place away from direct sunlight.
• Ensure the dropper is clean to maintain hygiene.
• If you experience skin irritation, dilute the drops with water or consult your doctor.
• Avoid contact with eyes; if contact occurs, rinse thoroughly with water.
• Wash your hands after using the drops to prevent accidental contact.
• Keep a record of your dosage and any changes in symptoms for future reference.