Nitrocin (25mg/5ml) 25 Injections For IV Infusion

Glyceryl Trinitrate, commonly known as nitroglycerin, works by releasing nitric oxide (NO) into the bloodstream upon metabolism. Nitric oxide is a potent vasodilator, meaning it relaxes smooth muscle cells within blood vessels, particularly in the veins and arteries. This relaxation leads to peripheral vasodilation, resulting in decreased preload and afterload on the heart. The reduced preload decreases the volume of blood returning to the heart, while the lowered afterload reduces the force against which the heart must pump. Consequently, Glyceryl Trinitrate alleviates the heart's workload, improving blood flow and reducing blood pressure. This mechanism is particularly beneficial in conditions where rapid vasodilation is required, such as angina pectoris and acute heart failure.

Glyceryl Trinitrate 25mg

vasodilator

Injection

The following are the uses of Glyceryl Trinitrate 25mg injection:

• Used for treating and preventing chest pain in patients with heart disease
• Used for Angina relief, especially during an angina attack
• Used to reduce the heart's workload after a heart attack
• Used for Managing hypertension in emergency situations
• Used for Treating heart failure in combination with other medications
• Used for Dilating blood vessels to improve blood flow
• Used for Treating coronary artery spasms

In the case of an overdose of Glyceryl Trinitrate 25mg injection, symptoms may include severe headaches, dizziness, and a sudden drop in blood pressure. The patient may experience rapid heart rate, flushing, and a feeling of warmth. If multiple doses are administered within a short time, it can lead to a toxic accumulation, causing hypotension, bradycardia, and even collapse. Immediate medical attention is required to manage the symptoms and prevent further complications.

In the case of a missed dose of Glyceryl Trinitrate 25mg injection, it is important to administer the medication as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare professional for advice on how to safely resume the medication.

To administer the Glyceryl Trinitrate 25mg injection, clean the injection site with an alcohol wipe, insert the needle subcutaneously or intramuscularly as directed by your healthcare provider, and slowly inject the prescribed dose, ensuring the entire medication is delivered before withdrawing the needle.

Following are the conditions/situations when Glyceryl Trinitrate 25mg injection should not be administered:

• Should not be used in individuals with a known allergy to Glyceryl Trinitrate or nitrates.
• Contraindicated in patients with severe anemia or recent head injury/increased intracranial pressure.
• Not recommended for individuals with recent heart attack or myocardial infarction.
• Should not be used in patients with severe hypotension (very low blood pressure).
• Contraindicated in individuals with severe aortic/mitral valve stenosis (narrowing of heart valves).
• Not suitable for patients with acute/severe heart failure or cardiogenic shock.
• Should be avoided in patients with glaucoma.

The side effects of Glyceryl Trinitrate 25mg injection may include:

• Severe headaches or migraines
• Dizziness or lightheadedness
• Nausea and vomiting
• Rapid or irregular heartbeat (palpitations)
• Flushing or warmth in the face and chest
• Drop in blood pressure (hypotension)
• Skin rashes or itching
• Restlessness or anxiety

Following are the precautions and warnings for Glyceryl Trinitrate 25mg injection:

• This medication should be used with caution in patients with severe anemia, recent myocardial infarction, hypotension, or increased intracranial pressure, as it may exacerbate these conditions.
• Patients with a history of heart problems, such as heart failure, should be closely monitored as the medication can affect cardiovascular function.
• It is crucial to avoid sudden withdrawal, as it may lead to rebound hypertension or other adverse effects; always consult a doctor before stopping the treatment.
• Elderly patients may be more sensitive to the effects of this medication, so lower doses should be considered.
• Not recommended for individuals with known allergies to Glyceryl Trinitrate or similar compounds.
• Exercise caution when using in patients with severe liver disease, as the medication's metabolism may be affected.
• Always follow the prescribed dosage and administration instructions; an overdose can lead to severe side effects.

Following are the drug interactions for Glyceryl Trinitrate 25mg injection:

• Alcohol consumption can lead to increased hypotensive effects and potential orthostatic hypotension.
• Nitrates can interact with phosphodiesterase-5 (PDE-5) inhibitors like sildenafil, tadalafil, and vardenafil, causing severe hypotension.
• The hypotensive effect of nitrates may be enhanced by calcium channel blockers, leading to excessive blood pressure drop.
• Glyceryl trinitrate may interact with vasodilators such as hydralazine, causing a more significant drop in blood pressure.
• Antihypertensives, when combined with nitrates, can result in additive blood pressure reduction.
• Beta-blockers may potentiate the effects of nitrates, leading to prolonged hypotension.
• Diuretics can cause volume depletion, which may enhance the hypotensive effects of nitrates.

Following are the food interactions for Glyceryl Trinitrate 25mg injection:

• Alcohol consumption should be avoided as it may cause excessive vasodilation and hypotension, leading to a sudden drop in blood pressure.
• Grapefruit and grapefruit juice should be consumed with caution as they can inhibit the metabolism of Glyceryl Trinitrate, potentially resulting in increased drug levels and heightened side effects.
• Caffeine intake may need to be monitored as it can constrict blood vessels, counteracting the vasodilating effects of the medication.
• High-fat meals might delay the absorption of Glyceryl Trinitrate, affecting its onset of action.
• Avoid consuming large amounts of garlic as it can enhance the vasodilating effects of the injection, leading to hypotension.
• Be cautious with spicy foods as they may influence blood flow and interact with the medication's action.
• Always follow medical advice regarding dietary restrictions or modifications when using this medication.
• Certain foods rich in nitrates, like beetroot and some leafy greens, may interact with the medication's action and require monitoring.

Glyceryl Trinitrate 25mg injection should be stored in a controlled environment, specifically at room temperature between 20-25°C (68-77°F). Protect the injection from direct sunlight and moisture by keeping it in its original packaging, ensuring the container is tightly sealed. Avoid storing it in areas prone to temperature fluctuations, such as bathrooms, kitchens, or near windows, as heat and light can degrade the medication. Always check the expiration date, and never use the injection beyond its expiry. When disposing of unused or expired injections, do not flush or pour them down the drain; instead, follow local guidelines for pharmaceutical waste disposal or consult a healthcare professional for guidance on safe disposal practices. Keep the medication away from children to prevent accidental exposure.

Following are the quick tips for Glyceryl Trinitrate 25mg injection:

• Administer the injection under medical supervision as directed by your doctor.
• Ensure the injection is stored at room temperature, away from direct sunlight.
• Check the expiry date before use and do not use if expired.
• Follow proper injection technique; clean the injection site with an alcohol swab.
• Inject the prescribed dose subcutaneously or as instructed by your healthcare provider.
• Do not reuse needles or syringes; dispose of them safely after use.
• Inform your doctor if you experience severe headaches, dizziness, or chest pain after the injection.
• Keep a record of injection sites to rotate injection areas and minimize skin irritation.