NITRODERM TTS IMP 5MG PATCH 30'S

Glyceryl Trinitrate, commonly known as nitroglycerin, acts by releasing nitric oxide (NO) after being metabolized in the body. Nitric oxide is a potent vasodilator, meaning it relaxes smooth muscle cells within blood vessels. Specifically, it targets the vascular smooth muscle, leading to vasodilation of both arterial and venous beds. This mechanism results in reduced vascular resistance and decreased preload and afterload on the heart. The overall effect is a decrease in blood pressure and reduced strain on the heart, making it particularly useful in managing angina and other cardiovascular conditions.

vasodilator

The following are the uses of Glyceryl Trinitrate 0.5mg Patch:

• Used for Angina, providing rapid relief from chest pain by relaxing blood vessels.
• Used for Managing heart failure in emergency situations to reduce the workload on the heart.
• Used for Acute heart attacks, aiding in blood flow to the heart.
• Used for Blood pressure management during surgery.
• Used for Preventing and treating blood clots in coronary arteries.
• Used for Pre-conditioning the heart before cardiac surgery.
• Used for Certain cardiovascular conditions requiring rapid vasodilation.

In the case of an overdose of Glyceryl Trinitrate 0.5mg Patch, it is important to recognize the signs, which may include severe headaches, dizziness, fainting, and a rapid or pounding heartbeat. Promptly remove the patch and contact a healthcare professional or seek emergency medical care. Treatment for overdose may involve supportive care and monitoring of vital signs to ensure the patient's well-being.

In the case of a missed dose of Glyceryl Trinitrate 0.5mg Patch, it is important to apply a new patch as soon as you remember. You should not apply extra patches to make up for the missed dose. If it's almost time for your next scheduled dose, simply apply the next patch at the regular time. If you have any concerns or questions about missed doses, contact your healthcare provider for guidance on how to manage your medication schedule effectively.

To use the Glyceryl Trinitrate 0.5mg Patch, clean and dry the application site, open the sachet, peel off the protective liner, and apply the patch to the skin on the chest or upper arm, pressing firmly for 30 seconds to ensure good contact.

Here are the conditions or situations when Glyceryl Trinitrate 0.5mg Patch should not be used:

• Must not be used in individuals with a known allergy to glyceryl trinitrate or any nitrate medications.
• Not suitable for individuals with severe anemia or very low blood pressure.
• Contraindicated in patients with a recent head injury or increased intracranial pressure.
• Should not be applied if the patient has a tight, constrictive pericarditis.
• Avoid using this patch if the patient has a heart condition called cardiac tamponade.
• Not recommended for individuals with severe aortic stenosis.
• Must not be used in patients with acute glaucoma.
• Contraindicated during the use of medications for erectile dysfunction, such as sildenafil, tadalafil, or vardenafil.
• Should be avoided if the patient has taken a PDE5 inhibitor within the last 24 hours.

The side effects of Glyceryl Trinitrate 0.5mg Patch may include:

• Headache
• Dizziness
• Lightheadedness
• Flushing of the face and neck
• Nausea and vomiting
• Skin irritation at the application site
• Rapid or abnormal heart rate

Following are the precautions and warnings for Glyceryl Trinitrate 0.5mg Patch:

• Not suitable for individuals with a known allergy to glyceryl trinitrate or any other nitrates.
• Patients with a history of severe anemia or recent head injury should use with caution and under medical supervision.
• Avoid using alcohol or recreational drugs while on this medication, as it may cause dizziness and increase the risk of falls.
• Do not apply the patch on broken, irritated, or sunburned skin. Choose a different area of skin if the previous application site is still red.
• If you experience severe or persistent headaches, chest pain, or any unusual symptoms, remove the patch and seek medical attention immediately.
• Do not use more than the prescribed number of patches, and do not cut the patches into smaller pieces.
• Pregnant and breastfeeding women should consult their doctor before using this medication, as it may have potential risks to the fetus or infant.
• Keep out of reach of children and pets. If accidental ingestion occurs, seek medical help immediately.

Following are the drug interactions for Glyceryl Trinitrate 0.5mg Patch:

• Drugs that can cause hypotension (low blood pressure) like ACE inhibitors, beta-blockers, or diuretics may have additive effects, leading to excessive blood pressure drop.
• Alcohol consumption can increase the vasodilatory effects of Glyceryl Trinitrate, potentially causing severe hypotension.
• Sildenafil and similar phosphodiesterase type 5 inhibitors should be used cautiously, as they can potentiate the hypotensive effects of Glyceryl Trinitrate.
• Calcium channel blockers, such as verapamil or diltiazem, may enhance the vasodilatory and hypotensive effects of Glyceryl Trinitrate.
• The effects of Glyceryl Trinitrate may be reduced by medications that increase tolerance to nitrates, including erectile dysfunction medications and some anti-migraine drugs.
• Drugs that affect the metabolism of Glyceryl Trinitrate in the body, such as protease inhibitors and azole antifungals, can increase its blood levels and side effects.
• Glyceryl Trinitrate may interact with other nitrates or nitric oxide donors, leading to increased risk of side effects and hypotension.

Following are the food interactions for Glyceryl Trinitrate 0.5mg Patch:

• Alcohol consumption should be avoided as it may increase the risk of hypotension and dizziness.
• Grapefruit and its juice should be consumed with caution as they can affect the metabolism of the patch, potentially leading to increased side effects.
• Caffeine intake should be monitored as it may counteract the patch's effects, reducing its effectiveness in treating angina.
• Avoid high-fat meals as they can alter the absorption and distribution of the medication.
• Spicy foods might increase the risk of skin irritation at the patch application site.
• Avoid excessive salt intake, as it may reduce the patch's effectiveness in controlling blood pressure.
• Dairy products, particularly those high in fat, could potentially interfere with the absorption of the medication.
• Consuming large amounts of vitamin C-rich foods might affect the stability of the patch.

Glyceryl Trinitrate 0.5mg Patches should be stored in a cool, dry place, preferably in their original packaging or a sealed container, away from direct sunlight, heat, and moisture. It is crucial to maintain a temperature between 15-25°C (59-77°F) for optimal patch stability. Do not refrigerate or freeze the patches as it may affect their effectiveness. When disposing of used or expired patches, fold them in half with the sticky sides together and place them in a sealed plastic bag or container to prevent accidental exposure. Dispose of the sealed package in the trash, ensuring it is out of reach of children and pets. It is recommended to consult your pharmacist or healthcare provider for specific local guidelines on medication disposal to ensure environmental safety.

Following are the quick tips for Glyceryl Trinitrate 0.5mg Patch:

• Apply the patch on clean, dry, hairless skin as directed by your doctor.
• Choose a different skin site each time to avoid skin irritation.
• Wash your hands after handling the patch to avoid transferring the medication.
• Avoid applying the patch on injured, broken, or irritated skin.
• Do not cut the patch; use it as a whole for the prescribed duration.
• Store the patches in their original packaging at room temperature, away from heat and moisture.
• Consult your doctor if you experience severe or persistent headaches while using the patch.