Nitromint (6.5mg) 30 Retard Tablets

Nitroglycerin, the active ingredient in the 6.4mg tablet, exerts its therapeutic effects primarily through its conversion to nitric oxide (NO) in the body. This process occurs after nitroglycerin is metabolized by enzymes, mainly in the vascular smooth muscle cells. Nitric oxide is a potent vasodilator, meaning it relaxes the smooth muscle cells within the blood vessels. By doing so, nitroglycerin causes the dilation of both arterial and venous vasculature, leading to decreased vascular resistance. This mechanism of action results in reduced preload and afterload on the heart, which in turn lowers blood pressure and decreases the heart's oxygen demand. Consequently, nitroglycerin is particularly effective in managing conditions like angina pectoris, where improved blood flow to the heart and reduced cardiac workload are crucial for symptom relief.

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Tablet

The following are the uses of Nitroglycerine 6.4mg Tablet:

• Used for treating chest pain due to reduced blood flow to the heart.
• Used to relieve angina attacks, providing quick relief from pain and discomfort.
• Used as a preventive measure for angina, reducing the frequency and severity of attacks.
• Used to improve blood flow to the heart, ensuring proper oxygen supply to the cardiac muscles.
• Used in emergency situations to manage acute heart conditions, helping to stabilize the patient.
• Used as a short-term solution while long-term treatment plans are established.

In the case of an overdose of Nitroglycerin 6.4mg Tablets, symptoms may include severe headaches, dizziness, fainting, and a sudden drop in blood pressure. This can lead to a rapid and weak pulse, difficulty breathing, and even loss of consciousness. Immediate action should be taken by contacting emergency medical services, especially if the individual experiences chest pain, blurred vision, or any signs of a severe allergic reaction. Prompt medical intervention is crucial to manage the overdose and prevent potential complications.

In the case of a missed dose of Nitroglycerine 6.4mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, it's best to set reminders or keep the medication in a visible place to help you remember to take it as prescribed. Consult your healthcare provider if you have any concerns or questions about managing missed doses.

To use Nitroglycerine 6.4mg Tablet, place the tablet under your tongue (sublingually) and allow it to dissolve completely, following the instructions provided by your healthcare professional; it is typically taken as needed for chest pain (angina) with a dosage interval of at least 5 minutes between doses, not exceeding 3 doses in 15 minutes.

Here are the situations when Nitroglycerin 6.4mg Tablet should not be used:

• Must not be taken if you are allergic to nitroglycerin or any other nitrates.
• Not suitable for individuals with severe anemia or recent head injury.
• Contraindicated in patients with increased intracranial pressure.
• Avoid using if you have a condition called hypotension (very low blood pressure).
• Should not be used if you have a heart condition called hypertrophic cardiomyopathy.
• Not recommended for individuals with a recent heart attack and low blood pressure.
• Do not use if you have severe aortic valve stenosis (narrowing of the aortic valve in the heart).

The side effects of Nitroglycerine 6.4mg Tablet may include:

• Severe headaches or migraines
• Dizziness or lightheadedness
• Low blood pressure (hypotension)
• Flushing or redness of the skin
• Palpitations or rapid heartbeat
• Nausea and vomiting
• Skin rashes or itching
• Increased heart rate

Following are the precautions and warnings for Nitroglycerin 6.4mg Tablet:

• Not recommended for individuals with a known allergy to Nitroglycerin or other nitrates.
• Blood pressure should be monitored regularly, especially in patients with low blood pressure, as Nitroglycerin can cause a significant drop in blood pressure.
• May cause dizziness or lightheadedness, so caution is advised when performing tasks that require alertness. Avoid driving or operating heavy machinery if affected.
• Patients with anemia, recent heart attack, or head injury should use with caution and under medical supervision.
• Elderly patients may be more sensitive to the effects of Nitroglycerin, so dosage adjustments might be necessary.
• Do not abruptly discontinue the medication; gradual reduction is recommended to prevent withdrawal symptoms.
• Consult a doctor if chest pain worsens or becomes more frequent, as this may indicate a worsening heart condition.

Following are the drug interactions for Nitroglycerin 6.4mg Tablet:

• Alcohol consumption can enhance the vasodilatory effects of nitroglycerin, leading to a more pronounced drop in blood pressure.
• Nitroglycerin may interact with phosphodiesterase type 5 (PDE5) inhibitors like sildenafil, tadalafil, and vardenafil, resulting in a significant drop in blood pressure.
• Drugs that release nitric oxide, such as riociguat, can cause severe hypotension when used with nitroglycerin.
• Medications for erectile dysfunction, such as avanafil, can interact and lower blood pressure.
• Calcium channel blockers (e.g., amlodipine) and vasodilators (e.g., hydralazine) may have additive effects, requiring close monitoring.
• Sympathomimetic agents (e.g., epinephrine) can counteract the effects of nitroglycerin, potentially leading to rebound hypertension.
• Beta-blockers can mask the early warning symptoms of nitroglycerin overdose, making it crucial to monitor for signs of hypotension.

Following are the food interactions for Nitroglycerin 6.4mg Tablet:

• Grapefruit juice should be avoided as it can increase the levels of Nitroglycerin in the blood, leading to a potential overdose.
• Alcoholic beverages should be consumed with caution as they may lower blood pressure and increase the effects of Nitroglycerin, causing excessive dizziness and lightheadedness.
• Caffeinated drinks like coffee and tea may reduce the effectiveness of Nitroglycerin, as caffeine can constrict blood vessels, counteracting the medication's purpose.
• A diet rich in leafy green vegetables, such as spinach and kale, can enhance the effectiveness of Nitroglycerin by providing nitrates, which help relax blood vessels.
• Avoid high-fat meals as they can delay the absorption of Nitroglycerin, affecting its rapid action in emergency situations.
• Garlic and garlic supplements may increase the risk of bleeding when taken with Nitroglycerin, so consult your doctor before using them together.
• Chocolate, especially dark chocolate, contains compounds that can interact with Nitroglycerin and potentially increase its effects, so moderation is advised.
• Consult your healthcare provider for personalized advice on dietary adjustments to optimize the benefits of Nitroglycerin treatment.

The proper storage and disposal of Nitroglycerine 6.4mg Tablets are crucial for safety. Store the tablets in a cool, dry place, preferably at room temperature, ensuring they are protected from direct sunlight and moisture. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. Avoid extreme temperatures, such as those near heat sources or in the bathroom, as they can impact the medication's effectiveness. Always check the expiration date, and if the tablets are no longer needed or have expired, proper disposal is essential. Do not flush them or pour them down the drain; instead, consult a pharmacist or healthcare professional for guidance on safe disposal methods. Keep all medications out of children's reach to prevent accidental consumption.

Following are the quick tips for Nitroglycerine 6.4mg Tablet:

• Always carry your medication with you, especially when travelling, to ensure immediate access during an angina attack.
• Store the tablets in their original container, away from heat, light, and moisture.
• Do not crush or chew the tablets; place them under your tongue for sublingual use as directed.
• Remain seated or lying down when taking the medication to prevent dizziness.
• If you experience a severe headache after taking the tablet, it may be a side effect; consult your doctor.
• Do not take this medication with erectile dysfunction drugs, as it can lead to dangerous side effects.
• Inform your doctor about all medications you're taking to avoid potential interactions.