Nizoral (20mg) 10g Cream

Ketoconazole cream primarily exerts its antifungal activity by disrupting the synthesis of ergosterol, a crucial component of fungal cell membranes. It selectively inhibits an enzyme called lanosterol 14-alpha-demethylase, which is responsible for converting lanosterol to ergosterol in fungal cells. This inhibition leads to a decrease in ergosterol production, resulting in impaired fungal membrane integrity and function. By compromising the structure and stability of the fungal cell membrane, ketoconazole disrupts essential cellular processes, such as permeability, nutrient uptake, and maintenance of cellular homeostasis, ultimately leading to fungal cell death or inhibition of growth. This mechanism of action specifically targets fungi without significantly affecting mammalian cells, making it an effective treatment for various dermatophytic infections.

Ketoconazole

Antifungal Cream

Cream

The following are the uses of Ketoconazole Cream:

• Used for treating fungal skin infections such as athlete's foot, jock itch, ringworm, and yeast infections.
• Used for relieving itching, redness, and discomfort associated with these skin conditions.
• Used for inhibiting the growth of fungi and restoring the skin's natural balance.
• Used for preventing the spread of infection to healthy skin areas.
• Used for maintaining skin health and integrity during antifungal treatment.
• Used for managing skin inflammation and irritation caused by fungal infections.
• Used for promoting the healing process of affected skin areas.
• Used for providing targeted relief and supporting overall skin recovery.

In the case of an overdose of Ketoconazole Cream, it is unlikely to cause significant harm if accidentally ingested or applied excessively. However, if an individual experiences any adverse effects, such as severe skin irritation, prolonged or excessive use should be discontinued. It is advisable to contact a healthcare professional for guidance and to determine the best course of action if an overdose is suspected, especially if there are any unusual symptoms or discomfort.

In the case of a missed dose of Ketoconazole Cream, it is important to apply the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed application and resume your regular schedule. Do not apply extra cream to make up for the missed dose, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a medication tracker to help you stay on track with your treatment plan. It is always best to consult your healthcare provider for specific instructions regarding missed doses.

To use Ketoconazole Cream, clean and dry the affected skin area, then apply a thin layer of the cream, gently rubbing it into the skin as directed by your healthcare provider, typically twice a day or as prescribed.

Here are the conditions or situations when Ketoconazole Cream should not be used:

• Avoid using this cream if you have a known allergy or sensitivity to ketoconazole or any other ingredients in the cream.
• Do not use on open wounds, broken or infected skin.
• Not suitable for individuals with a history of liver problems or liver disease.
• Contraindicated for those who are taking certain medications that may interact with ketoconazole, such as oral anticoagulants, and those who are sensitive to other antifungal medications.
• Should not be used for children without medical advice.
• Avoid using this cream on areas of the body not affected by the fungal infection.
• Do not use if the cream is expired or if the seal is broken.
• Not recommended for individuals with a history of hypersensitivity reactions to azole antifungals.

The side effects of Ketoconazole Cream may include:

• Skin irritation at the application site
• Redness or inflammation
• Itching or burning sensation
• Dry skin
• Peeling or flaking of the skin
• Allergic reactions (such as rash, hives, or itching)
• Folliculitis (inflammation of hair follicles)

Following are the precautions and warnings for Ketoconazole Cream:

• Avoid applying the cream in or around the eyes, mouth, or nose. In case of accidental contact, rinse thoroughly with water.
• Do not use Ketoconazole Cream if you are allergic to any of its ingredients. Always check the ingredient list before use.
• This medication is for external use only. Do not swallow or ingest it.
• Do not use the cream on broken or infected skin. Seek medical advice if the treated area shows signs of infection.
• Prolonged use over large areas of skin, especially in children, should be avoided unless directed by a healthcare professional.
• If you are pregnant or breastfeeding, consult your doctor before using this medication. It may have potential risks for the fetus or infant.
• Keep Ketoconazole Cream out of the reach of children. Store it at room temperature, away from direct sunlight and moisture.

Following are the drug interactions for Ketoconazole Cream:

• Avoid combining with other topical antifungals like miconazole or terbinafine, as it may lead to skin irritation or reduced effectiveness.
• Concomitant use with oral ketoconazole or other systemic antifungals may increase the risk of adverse effects due to increased systemic absorption.
• Ketoconazole may reduce the effectiveness of oral contraceptives, requiring additional contraceptive measures.
• Potentially serious interactions with certain medications metabolized by the liver, such as warfarin, leading to increased risk of bleeding.
• Drugs that prolong the QT interval, such as certain antiarrhythmics or antipsychotics, may have their effects enhanced, increasing the risk of cardiac arrhythmias.
• Corticosteroids applied topically with ketoconazole may increase the risk of skin atrophy and other local side effects.
• Caution with immunosuppressants, as ketoconazole may alter their metabolism and effectiveness.

Following are the food interactions for Ketoconazole Cream:

• Avoid consuming grapefruit and grapefruit juice, as these may interfere with the medication's metabolism, leading to increased drug levels in the body.
• Alcoholic beverages should be limited or avoided as they may cause increased skin irritation or dryness when used with Ketoconazole Cream.
• Dairy products and foods high in fat may not directly interact with the cream, but maintaining a balanced diet is essential for overall skin health.
• Avoid spicy foods as they may exacerbate skin sensitivity and discomfort, especially if applied near the mouth or nose.
• Caffeinated beverages might increase skin sensitivity and should be consumed in moderation.
• Stay hydrated by drinking plenty of water to support overall skin hydration, which is beneficial when using any topical medication.
• Consult your healthcare provider about any specific dietary restrictions or recommendations while using Ketoconazole Cream to ensure the best treatment outcome.

Ketoconazole Cream should be stored in a cool and dry environment, preferably at room temperature, ensuring it is protected from excessive heat and direct sunlight. Keep the cream in its original container, tightly sealed, to maintain its integrity and prevent contamination. It is crucial not to store it in bathrooms or areas with high humidity. Always verify the expiration date, and if the cream is expired or no longer needed, do not dispose of it by flushing or pouring it down the drain. Instead, consult a pharmacist or healthcare professional for appropriate disposal methods to ensure environmental safety. Keep the cream away from children to prevent accidental contact or ingestion.

Following are the quick tips for Ketoconazole Cream:

• Wash and dry the affected area before applying the cream.
• Apply a thin layer of cream to the affected skin, ensuring complete coverage.
• Gently rub the cream into the skin until it is absorbed.
• Wash your hands after applying the cream, unless the hands are the treated area.
• Avoid applying the cream to broken or irritated skin.
• Do not cover the treated area with bandages or wrappings unless directed by a healthcare professional.
• If using other topical medications, apply them at different times to avoid potential interactions.