NOCARIS SYP 15ML

Levamisole syrup or suspension acts as an immunomodulator and an anti-helminthic agent. Its primary mechanism of action involves stimulating the immune system by enhancing the production and activity of various immune cells, such as neutrophils, macrophages, and T-lymphocytes. Levamisole increases phagocytosis, promotes the release of cytokines and interferons, and enhances the cytotoxic activity of natural killer cells. This immune-boosting effect is believed to contribute to its anti-helminthic properties, as it helps the body's immune response against parasitic infections. Additionally, levamisole may interfere with the energy metabolism of parasitic worms, leading to their paralysis and eventual elimination from the host.

Levamisole

Anthelmintic

Suspension

The following are the uses of Levamisole Syrup/Suspension:

• Used for treating parasitic worm infections, such as hookworms, roundworms, and whipworms.
• Used for controlling and eliminating parasitic infestations in the intestines.
• Used for improving digestion and nutrient absorption by removing worms that interfere with these processes.
• Used for reducing abdominal pain, diarrhea, and other gastrointestinal symptoms caused by worm infections.
• Used for preventing the spread of worm infections to other individuals in close contact.
• Used for promoting overall health and well-being by addressing parasitic infections.
• Used for supporting the immune system by removing worm infestations that can weaken the body's defenses.

In the case of an overdose of Levamisole Syrup/Suspension, individuals may experience severe gastrointestinal symptoms such as nausea, vomiting, and abdominal pain. Central nervous system effects, including dizziness, headache, and seizures, can also occur. Immediate medical intervention is necessary, with treatment focusing on managing symptoms and providing supportive care. Prompt medical attention can help mitigate the potentially serious consequences of an overdose, ensuring the patient's well-being and recovery.

In the case of a missed dose of Levamisole Syrup/Suspension, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed and to determine if any adjustments to your treatment plan are necessary.

To administer Levamisole Syrup/Suspension, shake the bottle well, measure the prescribed dose with an oral syringe or a measuring cup, and take it orally, preferably on an empty stomach, as directed by your healthcare professional, ensuring not to exceed the recommended dosage.

Following are the conditions when Levamisole Syrup/Suspension should not be used:

• Avoid use in patients with known hypersensitivity or severe allergic reactions to Levamisole or any of its excipients.
• Do not use in patients with severe bone marrow depression or low white blood cell counts.
• Contraindicated in patients with severe uncontrolled infections.
• Not suitable for patients with a history of autoimmune diseases such as lupus, rheumatoid arthritis, or severe skin reactions.
• Should not be administered to infants or very young children.
• Avoid use during pregnancy or breastfeeding.
• Do not use in patients with known or suspected immunodeficiency disorders.
• Contraindicated in patients with a history of gastrointestinal bleeding or perforation.

The side effects of Levamisole Syrup/Suspension may include:

• Nausea and vomiting
• Diarrhea
• Loss of appetite
• Dizziness
• Skin rashes or itching
• Fatigue and weakness
• Fever
• Abnormal liver function tests

Following are the precautions and warnings for Levamisole Syrup/Suspension:

• This medication is intended for specific parasitic infections and should not be used for any other conditions without medical advice.
• Not suitable for individuals with known allergies to Levamisole or any other ingredients in the syrup/suspension.
• Patients with a history of autoimmune diseases, blood disorders, or kidney problems should use with caution and under medical supervision.
• Levamisole may cause dizziness or drowsiness, so activities requiring alertness, such as driving or operating machinery, should be avoided until you know how the medication affects you.
• Alcohol consumption should be avoided as it may increase the risk of certain side effects.
• If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking this medication.
• Store Levamisole Syrup/Suspension at room temperature, away from direct sunlight and moisture, and keep out of reach of children and pets.

Following are the drug interactions for Levamisole Syrup/Suspension:

• Concomitant use with other immunosuppressants (e.g., cyclosporine, tacrolimus) may increase the risk of infections and suppress the immune system further.
• Levamisole can interact with anticoagulants like heparin, potentially affecting blood clotting and requiring close monitoring of coagulation parameters.
• Use with drugs that affect the central nervous system (CNS), such as opioids or benzodiazepines, may result in enhanced CNS effects and respiratory depression.
• It may decrease the effectiveness of live vaccines, so live vaccinations should be avoided during treatment.
• Levamisole can increase the effects of hypoglycemic agents, leading to low blood sugar levels.
• Interactions with certain antibiotics, such as penicillins and cephalosporins, can reduce their absorption and efficacy.
• The syrup/suspension form may contain sugars or alcohol, which could interact with medications that require monitoring of sugar intake or alcohol abstinence.

Following are the food interactions for Levamisole Syrup/Suspension:

• Alcohol consumption should be avoided as it may increase the risk of adverse effects and could potentially reduce the effectiveness of the medication.
• Grapefruit and grapefruit juice are to be avoided as they can inhibit the metabolism of Levamisole, leading to increased drug levels in the body and potentially more side effects.
• High-fat meals may affect the absorption of Levamisole, possibly delaying the onset of action.
• Dairy products like milk and yogurt can potentially decrease the absorption of Levamisole, so it's best to separate these by a few hours.
• Consuming foods rich in Vitamin B6 (like bananas, chicken, and spinach) might reduce the effectiveness of Levamisole, as Vitamin B6 can interfere with its mechanism of action.
• Garlic, a natural blood thinner, could enhance the anticoagulant effects of Levamisole, potentially increasing the risk of bleeding.
• Green tea, known for its antioxidant properties, may interact with Levamisole and affect its metabolism, potentially altering its effectiveness.
• Vitamin C supplements or foods rich in Vitamin C (such as oranges, bell peppers) might decrease the bioavailability of Levamisole, leading to reduced effectiveness.

Levamisole Syrup/Suspension should be stored in a secure and controlled environment, preferably in a locked cabinet or storage area, to prevent unauthorized access. Keep it at room temperature, away from excessive heat or moisture, and avoid exposure to direct sunlight as it can degrade the medication. Always check the expiration date on the label, and do not use the syrup if it has expired. When disposing of Levamisole Syrup/Suspension, do not pour it down the drain or flush it; instead, follow local guidelines for pharmaceutical waste disposal or consult your pharmacist for guidance. It is crucial to handle this medication with care and keep it out of the reach of children and pets to prevent accidental consumption, as it can be harmful if ingested without medical supervision.

Following are the quick tips for Levamisole Syrup/Suspension:

• Consult your doctor for the right dosage and duration specific to your condition.
• Administer the prescribed dose using the measuring cup or syringe provided.
• Ensure you measure the correct amount; do not estimate.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Check the expiration date before use and discard if expired.
• Do not freeze the syrup as it may affect its effectiveness.
• Regularly clean the bottle cap to prevent contamination.