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Nolvadex (10mg) 30 Tablets

Nolvadex (10mg) 30 Tablets

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  • Manufacturer BIOTEST PHARMACEUTICALS (PVT.) LTD.
  • Generic Name Tamoxifen

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Tamoxifen, a 10mg tablet, exerts its mechanism of action primarily by acting as a selective estrogen receptor modulator (SERM). It binds to estrogen receptors in various tissues, including breast tissue, and exhibits a tissue-specific agonist or antagonist effect. In breast cells, tamoxifen predominantly acts as an estrogen antagonist, blocking the binding of estrogen to its receptors. This inhibition prevents estrogen-induced cell proliferation, thereby inhibiting the growth and progression of estrogen-receptor-positive breast cancer cells. By occupying the estrogen receptors, tamoxifen interferes with the estrogen-mediated signaling pathways that promote cancer cell growth and survival. This mechanism contributes to its effectiveness in treating hormone-receptor-positive breast cancer and reducing the risk of cancer recurrence.

  • Ingredients

    Tamoxifen
  • Drug Class

    Selective estrogen receptor modulator.

  • Dosage Form

    Tablet

  • Uses

    The following are the uses of Tamoxifen 10mg Tablet:

    • Used for treating early and advanced breast cancer in women before and after menopause.
    • Used to reduce the risk of developing breast cancer in high-risk women.
    • Used for managing ductal carcinoma in situ (DCIS), a non-invasive breast cancer.
    • Used to reduce the incidence of contralateral (in the opposite breast) breast cancer.
    • Used in the treatment of certain types of infertility in women.
    • Used for alleviating gynecomastia (abnormal breast growth in men).
    • Used to lower the chances of breast cancer recurrence after surgery and radiation.
  • In case of Overdose

    In the case of an overdose of Tamoxifen 10mg Tablets, it is important to recognize the potential symptoms and seek medical advice promptly. Overdosing on this medication may lead to an increased risk of side effects such as nausea, vomiting, hot flashes, and skin rash. If you suspect an overdose, contact a healthcare professional immediately for guidance. They will provide specific instructions based on the severity of the overdose and the individual's medical history. Prompt action can help manage any adverse effects effectively.

  • Missed Dose

    In the case of a missed dose of Tamoxifen 10mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare professional for advice on how to get back on track with your treatment plan, as they can provide specific guidance based on your medical history and condition.

  • How To Use

    To take Tamoxifen 10mg Tablet, swallow the tablet whole with a glass of water, usually once or twice daily, or as directed by your healthcare professional, and it can be taken with or without food, but it's best to take it at the same time each day to maintain consistent levels of the medication in your body.

  • When Not to Use

    Here are the conditions under which Tamoxifen 10mg Tablet should not be used:

    • Must not be used in individuals with a known allergy to Tamoxifen or similar medications.
    • Contraindicated in individuals with a history of blood clots or stroke.
    • Not suitable for women who are breastfeeding.
    • Should not be used in patients with uncontrolled high cholesterol or lipid levels.
    • Avoid use in individuals with a history of eye problems, such as cataracts or vision issues.
    • Not recommended for individuals with a history of liver disease or impaired liver function.
    • Contraindicated in pregnant women or those planning to become pregnant.
  • Side Effects

    The side effects of Tamoxifen 10mg Tablet may include:

    • Hot flashes
    • Nausea and vomiting
    • Weight loss or gain
    • Fatigue and weakness
    • Skin rash or itching
    • Hair thinning or hair loss
    • Mood changes, including depression or anxiety
    • Increased risk of blood clots
  • Precautions & Warnings

    Following are the precautions and warnings:

    • Tamoxifen 10mg Tablet should not be used in patients who are hypersensitive or allergic to tamoxifen or any of its ingredients.
    • This medication requires close monitoring for patients with a history of blood clots, stroke, or liver disease, as it may increase the risk of these conditions.
    • Patients experiencing hot flashes, vaginal bleeding, or vision changes should seek medical advice immediately.
    • Tamoxifen may increase the risk of uterine cancer, so any unusual vaginal discharge, bleeding, or pain should be reported to a healthcare professional.
    • Patients with a history of deep vein thrombosis or pulmonary embolism should exercise caution as the medication can elevate these risks.
    • Women who are pregnant or planning to become pregnant should not use this medication, as it may cause fetal harm.
    • Breastfeeding women should consult their doctor as tamoxifen can pass into breast milk and potentially harm the nursing infant.
    • Regular eye examinations are recommended during treatment to monitor for any visual disturbances or changes.
  • Drug Interactions

    Following are the drug interactions for Tamoxifen 10mg Tablet:

    • Concomitant use with certain hormonal therapies, such as aromatase inhibitors (e.g., anastrozole, letrozole), may reduce the effectiveness of tamoxifen.
    • Tamoxifen can affect the metabolism of various drugs by inhibiting CYP2D6 enzyme, potentially leading to increased or decreased drug levels of medications like antidepressants (e.g., paroxetine, fluoxetine) and some antipsychotics.
    • It may interact with anticoagulants like warfarin, requiring close monitoring of blood clotting parameters.
    • Use with selective serotonin reuptake inhibitors (SSRIs) can increase the risk of abnormal bleeding.
    • Tamoxifen may enhance the effects of oral anti-diabetic drugs, requiring careful monitoring of blood glucose levels.
    • Caution is advised when combining with certain medications that affect the heart's electrical activity, such as quinidine or amiodarone, as this may increase the risk of QT prolongation.
    • Avoid concurrent use with estrogen-containing products, as they may reduce the effectiveness of tamoxifen.
  • Food Interactions

    Following are the food interactions to be aware of with Tamoxifen 10mg Tablet:

    • Grapefruit and grapefruit juice consumption should be limited as they can interfere with the metabolism of Tamoxifen, potentially leading to increased drug levels in the body.
    • Avoid high-fat meals as they may decrease the absorption of Tamoxifen, reducing its effectiveness.
    • It is advisable to maintain a consistent level of vitamin K-rich foods in your diet, as Tamoxifen may affect blood clotting.
    • Alcohol consumption should be minimized as it can increase the risk of liver problems and potentially reduce the effectiveness of Tamoxifen.
    • Soy-based foods and supplements containing isoflavones might interact with Tamoxifen; consult your healthcare provider for guidance.
    • Certain vegetables like broccoli, Brussels sprouts, and cabbage contain compounds that can influence the metabolism of Tamoxifen; consider discussing this with your doctor.
    • Avoid excessive consumption of foods high in calcium, as they may interfere with the absorption of Tamoxifen.
    • Always consult your healthcare provider for personalized advice regarding dietary considerations while taking Tamoxifen.
  • Storage/Disposal

    Tamoxifen 10mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area. Keep the tablets in their original container, tightly sealed, to maintain their integrity and protect them from moisture and light. It is crucial to store the medication at room temperature, avoiding exposure to extreme heat or cold, as temperature fluctuations can impact its effectiveness. Do not store the tablets in the bathroom medicine cabinet due to the humidity. Always check the expiration date, and if the medication has passed its expiry, do not use it and dispose of it safely. For proper disposal, do not flush the tablets down the toilet or pour them into a drain; instead, consult a pharmacist or local waste management guidelines for appropriate pharmaceutical waste disposal methods. Keep the medication out of children's reach to prevent accidental ingestion.

  • Quick Tips, if any

    Following are the quick tips for Tamoxifen 10mg Tablet:

    • Take the tablet as directed by your doctor, usually once or twice daily.
    • Consume the tablet at the same time each day to maintain consistent levels.
    • Swallow the tablet whole with a full glass of water, preferably on an empty stomach.
    • Avoid crushing or chewing the tablet to prevent a bitter taste.
    • Do not take with grapefruit juice as it may affect drug absorption.
    • Inform your doctor about all medications you're taking to avoid interactions.
    • Store at room temperature, away from light and moisture.

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