Norgesta Tab

Norethisterone is a synthetic progestin that primarily exerts its effects by mimicking the actions of the natural hormone progesterone. Its mechanism of action involves binding to and activating progesterone receptors in various target tissues, particularly in the uterus and cervix. Upon binding, norethisterone inhibits the release of luteinizing hormone (LH) from the pituitary gland, which suppresses ovulation. This is achieved by maintaining a constant level of progesterone-like activity, preventing the mid-cycle surge of LH that is necessary for ovulation to occur. Additionally, norethisterone alters the cervical mucus, making it thicker and less penetrable by sperm, thereby providing an additional barrier to fertilization.

Progestogen

Tablet

The following are the uses of Norethisterone Tablet:

• Used for delaying periods, providing more control over menstruation timing.
• Used for managing irregular or heavy periods, helping to regulate menstrual cycles.
• Used for treating endometriosis pain and symptoms, offering relief.
• Used for reducing hot flashes and other menopausal symptoms.
• Used for preventing uterine lining thickening in hormone replacement therapy.
• Used for treating acne by regulating hormonal imbalances.
• Used for supporting fertility treatments, aiding in successful outcomes.
• Used for emergency contraception, as a backup option to prevent pregnancy.

To be taken as per doctor's prescription

In the case of an overdose of Norethisterone Tablets, it is important to recognize the potential symptoms, which may include nausea, vomiting, dizziness, and in severe cases, fainting or loss of consciousness. If an overdose is suspected, seek medical advice promptly. Treatment may involve supportive care and managing any adverse effects, ensuring the patient's safety and well-being. Timely intervention can help prevent complications and ensure a positive outcome.

In the case of a missed dose of Norethisterone Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is crucial not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare provider for advice on how to adjust your medication regimen and ensure effective treatment. Always keep a consistent routine to minimize the chances of missing doses.

To take Norethisterone Tablets, swallow the tablet whole with a full glass of water, following the prescribed dosage provided by your healthcare professional; take it consistently at the same time each day to maintain its effectiveness, and complete the full course as directed.

Here are the conditions and situations when Norethisterone Tablet should not be taken:

• Allergy Should not be used in individuals with a known or suspected allergy or hypersensitivity to norethisterone or any of the tablet's components.
• Thrombosis and Blood Clots Contraindicated in individuals with a history or current presence of blood clots, such as deep vein thrombosis (DVT) or pulmonary embolism.
• Stroke and Heart Attack Not suitable for individuals who have had a stroke or heart attack in the past, or who have risk factors for these conditions.
• Certain Cancers Should not be used in patients with known or suspected hormone-dependent cancers, such as breast cancer or endometrial cancer.
• Liver Disease Contraindicated in patients with severe liver impairment or liver disease, as it can affect drug metabolism.
• Undiagnosed Vaginal Bleeding Not recommended for women with undiagnosed abnormal genital bleeding until the cause has been determined.
• Migraine Should be used with caution in individuals with a history of migraine headaches, as it may aggravate the condition.
• Diabetes Caution is advised in individuals with diabetes, as norethisterone can affect blood sugar control.

The side effects of Norethisterone Tablet may include:

• Irregular menstrual bleeding or spotting
• Nausea and vomiting
• Headaches
• Breast tenderness or pain
• Mood changes, including depression or irritability
• Acne or skin rashes
• Weight gain or fluid retention
• Changes in libido

Following are the precautions and warnings for Norethisterone Tablet:

• Not recommended for individuals with a history of allergic reactions to norethisterone or related hormones.
• Patients with a history of blood clots, stroke, or heart attack should exercise caution and consult a doctor before use, as it may increase the risk of these conditions.
• It may cause changes in blood sugar levels, so diabetic patients should monitor their blood sugar regularly.
• May cause fluid retention, so individuals with kidney or liver problems should use with caution and under medical supervision.
• Can affect mood and may cause mood swings, depression, or anxiety. Discontinue use and seek medical advice if any mental health changes occur.
• Not recommended for long-term use without medical supervision. Prolonged use may increase the risk of certain cancers, such as breast or liver cancer.
• Smoking while taking Norethisterone increases the risk of serious cardiovascular side effects. It is advisable to quit smoking during treatment.

Following are the drug interactions for Norethisterone Tablet:

• It may decrease the effectiveness of anticoagulants like warfarin, requiring close monitoring of coagulation parameters.
• Combining with other progestins or estrogens can increase the risk of side effects associated with these hormones.
• Norethisterone can interact with insulin and oral antidiabetic drugs, affecting blood glucose levels.
• The effect of corticosteroids may be altered, leading to decreased efficacy or increased side effects.
• Certain anticonvulsant medications, such as phenytoin or carbamazepine, can reduce the effectiveness of Norethisterone.
• Caution is advised when using with enzyme-inducing drugs, as these may decrease Norethisterone's plasma concentration.
• The tablet may impact the metabolism of other drugs metabolized by the liver, potentially requiring dose adjustments.

Following are the food interactions for Norethisterone Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they can interfere with the metabolism of Norethisterone, leading to increased drug levels in the body.
• Alcohol intake is generally not recommended with Norethisterone as it may increase the risk of side effects like nausea and dizziness.
• Foods high in fat can affect the absorption of Norethisterone, potentially reducing its effectiveness.
• Avoid high-sodium foods as Norethisterone may lead to sodium retention, and excessive sodium intake can increase blood pressure.
• Limit caffeine intake as it may interact with Norethisterone, causing increased heart rate and blood pressure.
• Avoid excessive sugar consumption, especially if you have diabetes or are at risk of diabetes, as Norethisterone can affect blood sugar levels.
• Ensure adequate hydration, as Norethisterone can sometimes cause dehydration due to its diuretic effect.
• There are no specific food restrictions, but maintaining a balanced diet is essential for overall health while taking Norethisterone.

Norethisterone Tablets should be stored in a cool, dry location, ideally at room temperature, and shielded from direct sunlight and moisture. To maintain its integrity and prevent contamination, it is crucial to keep the medication securely sealed in its original packaging. Avoid storing it in areas prone to temperature fluctuations, such as bathrooms, kitchens, or near heating appliances, as heat can degrade the medication's quality. Regularly inspect the expiration date on the packaging, and if the medication is no longer needed or has expired, dispose of it responsibly. Do not dispose of it via the toilet or drain; instead, consult your pharmacist or local waste management guidelines for safe disposal practices. Ensure that the medication is kept in a secure place, out of the reach of children, to prevent accidental ingestion.

No

Following are the quick tips for Norethisterone Tablet:

• Consult your doctor for the right dosage and duration of treatment.
• Start taking the tablet as soon as your period starts or as advised by your doctor.
• Take the tablet at the same time each day to maintain consistent blood levels.
• Complete the full course of medication, even if you feel better earlier.
• Inform your doctor if you have a history of blood clots, heart disease, or liver problems.
• Avoid smoking and alcohol consumption while taking this medication.
• Store the tablets in a cool, dry place, away from direct sunlight.