NORIGEST 1ML INJ

Norethisterone injection works primarily by mimicking the effects of the hormone progesterone in the body. It competitively binds to progesterone receptors in various tissues, particularly in the uterus and cervix. This binding inhibits the release of hormones that stimulate the growth of the uterine lining, thereby suppressing ovulation. Norethisterone can also have an impact on the viscosity of cervical mucus, making it harder for sperm to penetrate, thus contributing to its contraceptive effect. Additionally, it may alter the endometrium, making it less receptive to implantation, further reducing the likelihood of pregnancy. The mechanism of action of norethisterone injection is centered around its ability to regulate hormonal activity and create an environment that is unfavorable for conception.

Progestogen.

injection

The following are the uses of Norethisterone Injection:

• Used for delaying periods, allowing for more control over menstruation timing.
• Used for managing menstrual irregularities and heavy bleeding, helping to regulate the cycle.
• Used for endometriosis treatment, reducing pain and managing symptoms.
• Used for contraception, providing an alternative birth control option.
• Used for hormone replacement therapy, balancing hormones and alleviating menopause symptoms.
• Used for treating certain types of cancer, particularly in hormone-sensitive tumors.
• Used for managing acne and hormonal skin issues, offering a potential long-term solution.
• Used for addressing PCOS symptoms, helping to regulate hormones and improve overall health.

In the case of an overdose of Norethisterone Injection, symptoms may include nausea, vomiting, breast tenderness, and headaches. Medical attention should be sought immediately if an overdose is suspected. The severity of symptoms can vary, and individuals may experience additional side effects. It is important to contact a healthcare professional or go to the nearest emergency department for appropriate treatment and monitoring. Timely intervention can help manage any adverse effects and ensure the well-being of the patient.

In the case of a missed dose of Norethisterone Injection, it is important to act promptly. If you realize you have missed a scheduled injection, administer the missed dose as soon as possible, but avoid doubling the dose to catch up. If the next scheduled injection is due soon, skip the missed dose and continue with the regular injection schedule. However, if you frequently miss doses, it is crucial to consult your healthcare provider for guidance on managing your medication routine effectively. They can provide advice on how to handle missed doses and ensure you receive the full benefits of the medication.

To administer the Norethisterone Injection, clean the injection site with an alcohol wipe, insert the needle at a 90-degree angle into the muscle, and slowly inject the medication, ensuring the entire dose is delivered, then gently remove the needle and apply light pressure with a sterile bandage if needed.

Norethisterone Injection should not be used in the following conditions:

• Hypersensitivity or allergy to norethisterone or any other components of the injection.
• Pregnancy, unless prescribed by a healthcare provider, as it may harm the fetus.
• Breastfeeding, unless advised by a healthcare provider, as it may pass into breast milk.
• Active or history of blood clots, deep vein thrombosis, pulmonary embolism, or stroke, as norethisterone may increase the risk of clotting.
• Liver disease or liver dysfunction, as norethisterone may affect liver function.
• Hormone-sensitive cancers, such as breast or uterine cancer, unless advised by a doctor.
• Undiagnosed vaginal bleeding or any type of unexplained abnormal bleeding from the reproductive tract.
• Severe hypertension (high blood pressure) or uncontrolled diabetes, as norethisterone may exacerbate these conditions.
• Women with a history of gallbladder disease or liver tumors should avoid using norethisterone unless prescribed by a healthcare provider.

The side effects of Norethisterone Injection may include:

• Irregular menstrual bleeding or spotting
• Breast tenderness or pain
• Headaches or migraines
• Nausea and sometimes vomiting
• Mood changes, including depression or irritability
• Acne or skin breakouts
• Weight fluctuations
• Changes in libido

Following are the precautions and warnings for Norethisterone Injection:

• Not recommended for individuals with a history of hypersensitivity or allergic reactions to norethisterone or any other ingredients in the injection.
• Patients with a history of blood clots, stroke, or cardiovascular diseases should use with caution, as it may increase the risk of these conditions.
• Caution is advised for individuals with liver or kidney problems, as it may require dosage adjustments.
• This injection may cause fluid retention, so patients with conditions like epilepsy, asthma, or heart failure should be monitored closely.
• Not suitable for long-term use; prolonged use may increase the risk of side effects.
• Women with undiagnosed abnormal genital bleeding should undergo thorough examination before using this medication.
• Pregnant women or those planning to become pregnant should not use this injection, as it may affect fetal development.

Following are the drug interactions for Norethisterone Injection:

• Norethisterone may interact with other hormonal medications like oral contraceptives, potentially affecting their efficacy and increasing the risk of breakthrough bleeding.
• Antifungal drugs such as ketoconazole and itraconazole can increase norethisterone levels, leading to heightened side effects.
• Rifampicin and other enzyme inducers can reduce the effectiveness of norethisterone by accelerating its metabolism.
• Phenytoin, carbamazepine, and barbiturates may decrease norethisterone levels, potentially reducing its contraceptive effect.
• St. John's Wort (Hypericum perforatum) may induce the metabolism of norethisterone, reducing its effectiveness.
• Combining norethisterone with certain antiretroviral medications may affect hormone levels and alter the effectiveness of both drugs.
• Caution is advised when using norethisterone with anticoagulants, as it may slightly increase the risk of blood clots. Regular monitoring is recommended.

Following are the food interactions for Norethisterone Injection:

• Avoid excessive caffeine intake as it may increase blood pressure and interact with the medication's effects.
• Limit the consumption of foods high in salt/sodium as this drug can cause sodium retention.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect hormone levels by altering liver enzyme function.
• Alcohol may increase the risk of side effects such as nausea, dizziness, and gastrointestinal issues when combined with this medication.
• A balanced diet with adequate protein, vitamins, and minerals is recommended to support overall health while using this injection.
• There is no specific food restriction, but maintaining a healthy diet is advisable to manage weight and overall well-being during treatment.
• Always consult your healthcare provider for personalized advice regarding dietary considerations and potential interactions.

Norethisterone Injection should be stored in a controlled environment, preferably between 68°F and 77°F (20°C and 25°C), with brief excursions permitted between 59°F and 86°F (15°C and 30°C). Protect it from light and excessive heat. Keep the injection in its original packaging until use to maintain sterility. Once opened, use the injection immediately and do not store any unused portion. Proper disposal of the injection is crucial; do not dispose of it in household garbage or pour it down the drain. Contact your healthcare provider or pharmacist for guidance on safe disposal methods to minimize environmental impact. Keep this medication out of the reach of children and pets to prevent accidental exposure.

Following are the quick tips for Norethisterone Injection:

• Ensure the injection is administered by a trained healthcare professional.
• Inform your doctor about any allergies or current medications.
• Relax and stay still during the injection process.
• Avoid rubbing or touching the injection site immediately after the injection.
• Dispose of used needles and syringes safely.
• If you experience any unusual symptoms after the injection, contact your doctor promptly.
• Keep a record of your injection dates for future reference.
• Store the injection as directed on the packaging or by your pharmacist.