Norplat-S (75/75mg) 10 Tablets

Clopidogrel and Aspirin are both antiplatelet drugs used to treat recent strokes and heart attacks. Clopidogrel belongs to the thienopyridine class and works by blocking phosphodiesterase-3 enzymes, which increases cyclic adenosine monophosphate levels, inhibiting platelet aggregation. Aspirin is an NSAID and analgesic that reduces thromboxane production, which inhibits blood clot formation and vasoconstriction. Both drugs reduce the risk of stroke and heart attacks while aiding in anti-inflammatory and pain-relieving effects.

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NSAID (Non Steroidal Anti-Inflammatory Drug), Antiplatelet

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Tablet

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Unveiling its multifaceted uses and transformative applications as follows:

• Clopidogrel 75mg tablets are used to prevent blood clots and to keep the blood flowing smoothly in your body, reducing the risk of stroke or heart attack.
• Aspirin 75mg tablets are used to relieve mild to moderate pain, fever, and swelling (inflammation).
• It is used to reduce the risk of serious issues associated with your heart for people with cardiovascular disease.
• It is used with aspirin to lower the risk of stroke in people who have had a stroke or Transient Ischaemic Attack (TIA).
• It is used to treat pulmonary embolism (blockage in a blood vessel in the lung) and deep vein thrombosis (DVT) (a blood clot in a vein).

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Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• For cardiovascular disease Clopidogrel- 75 mg once daily with the evening meal. Aspirin- 75-162 mg once daily.
• For acute coronary syndrome (ACS) Clopidogrel- 300 mg loading dose followed by 75 mg once daily. Aspirin- 300-325 mg once daily (recommended dose 75-162 mg once daily).
• For stroke and TIA (transient ischemic attack) Clopidogrel- 75 mg once daily with the evening meal. Aspirin- 75-325 mg once daily.

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An overdose of clopidogrel and aspirin can be harmful and should be treated promptly. Although they are commonly safe medications, an overdose can produce uncomfortable and hazardous side effects. Some possible effects of a clopidogrel overdose may include gastrointestinal issues such as abdominal pain, nausea, vomiting, and diarrhea. Aspirin overdose may also lead to these symptoms in addition to tinnitus, confusion, and dizziness. In worse cases, excessive bleeding and hypotension may occur.

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If you have missed a dose of your medication, it is important to take it as soon as possible unless it is almost time for your next dose. If you miss a dose by less than 4 hours, you may take the missed dose and proceed with your regular schedule. However, if you miss a dose by more than 4 hours, it is best to skip the missed dose and continue on your regular schedule. Should you be unsure about whether to take a missed dose, please consult with your doctor or pharmacist for further advice. Haematological medications, such as clopidogrel and aspirin, are blood thinner medications usually prescribed together for individuals who have recently had a heart attack or stroke. These medications aim to minimize the risk of dangerous bleeding or clotting. It is important to take these medications as directed by your doctor under close monitoring for optimal results and to report any adverse effects immediately. Are you concerned you might have experienced side effects from these medications?

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Before you start taking Clopidogrel and Aspirin, it is important to discuss with your doctor any potential allergies and pre-existing medical conditions you may have. These drugs are administered orally, usually at the same time, with water. The standard dose for adults is 75 mg of Clopidogrel and 75 to 325 mg of Aspirin, although your doctor may prescribe a different dosage based on your age, weight, gender, and medical history. It is essential to take these medicines consistently, preferably at the same time each day, to avoid missing a dose. If you miss a dose, take it as soon as you remember it, but if it is almost time for the next dose, skip the missed dose and follow the regular schedule. Do not change your dosage to make up for the missed dose. You should inform your doctor about any other medications you take, including vitamins, herbal supplements, and over-the-counter drugs, as they may interact with Clopidogrel and Aspirin. It is also essential to keep all your medical appointments and regularly monitor your blood pressure and cholesterol levels. Your doctor may perform specific tests such as liver function tests to monitor any changes in your body. If you experience intolerable or worsening side effects, inform your doctor immediately. The common side effects of Clopidogrel and Aspirin are nosebleed, stomach upset, heartburn, nausea, and vomiting.

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Discerning instances where this medication may not be appropriate:

• Are allergic to clopidogrel or aspirin (or any of the other ingredients in the medications)
• Have active bleeding or recent history of bleeding
• Have a low platelet count (thrombocytopenia)
• Have a history of bleeding ulcers or gastrointestinal bleeding
• Have liver disease or decreased liver function
• Have a stroke or TIA within the last week
• Have a history of intracranial hemorrhage (bleeding in the brain)
• Have advanced liver disease or cirrhosis
• Have anemia or low red blood cell count (known as hemolytic anemia)
• Have a vitamin K deficiency
• Are pregnant or planning to become pregnant. These medications are not recommended in pregnancy and breastfeeding as they can cause complications. Consult with your doctor about the best options for you during this time.

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Unraveling the side effects lurking behind this medications are as follows:

• Gum inflammation (gingival hyperplasia)
• Excessive growth of gum tissue
• Belly pain
• Nausea
• Vomiting
• Constipation
• Diarrhea
• Nosebleed
• Uneven heartbeat
• Skin rash
• Itching
• Bruising
• Increased risk of bleeding/bruising/bleeding gums

Aspirin

• Belly pain
• Nausea
• Vomiting
• Constipation
• Diarrhea
• Nosebleed
• Heartburn
• Peptic ulcer disease
• Asthma attacks
• Itchiness
• Increased risk of bleeding/bruising/bleeding gums

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Before using this medication, it is important to consider the following precautions and warnings:

• Caution is advised for patients with a recent transient ischemic attack (TIA) or stroke, particularly lacunar stroke within the past 180 days.
• Use with care in individuals with a history of peptic ulcer, gastroduodenal hemorrhage, or minor upper gastrointestinal symptoms, as well as those with glucose-6-phosphate dehydrogenase (G6PD) deficiency, gout, or a history of asthma or allergic disorders.
• Avoid use in patients with hypersensitivity or hematologic reactions to previous thienopyridine use, and those with lesions prone to bleeding (e.g., gastrointestinal or intraocular lesions) or at increased risk of bleeding (e.g., due to trauma or surgery).
• For elective surgery, consider discontinuing the medication 7 days prior to the procedure.
• Consider the patient’s CYP2C19 metabolic status, including likely intermediate, intermediate, likely poor, and poor metabolizers.
• Use with caution in individuals with mild to moderate renal and hepatic impairment.
• Consult a healthcare professional before using the medication during pregnancy (especially in the 1st and 2nd trimesters) to ensure safety.

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Drug interactions with Aspirin , Clopidogrel combination include:

• Other anticoagulants (e.g., warfarin, heparin) (increased risk of bleeding)
• NSAIDs (increased risk of gastrointestinal bleeding)
• Selective serotonin reuptake inhibitors (SSRIs) (increased risk of bleeding)
• Antiplatelet agents (e.g., ticagrelor) (additive antiplatelet effects, increased bleeding risk)
• Proton pump inhibitors (e.g., omeprazole) (may reduce the effectiveness of clopidogrel)
• CYP2C19 inhibitors (e.g., ketoconazole) (may increase clopidogrel levels, increased bleeding risk)
• Calcium channel blockers (e.g., diltiazem) (may alter the effectiveness of antiplatelet effects)
• Rifampin (may decrease clopidogrel levels, reducing effectiveness)
• Lithium (may increase risk of bleeding)
• Herbal products (e.g., ginkgo biloba) (may increase bleeding risk)

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The food interactions that should be considered while using Aspirin and clopidogrel are:

• Increased risk of gastrointestinal bleeding with alcohol.
• Decreased rate but not the extent of absorption with food.

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Both clopidogrel and aspirin are oral medications, with clopidogrel typically prescribed to be taken once daily, and aspirin taken multiple times per day (such as twice or thrice daily). These medications share several storage requirements, primarily being stored at room temperature in an area free from heat, moisture, and light. This entails storing clopidogrel and aspirin away from the bathroom and refrigerator, as well as keeping the pills in their original containers. Clopidogrel should be stored between 20°C to 25°C (68°F to 77°F), while aspirin should be stored at temperatures below 30°C (86°F). It is advised to consult a licensed medical practitioner or a pharmacist for personalized storage instructions considering your specific medical circumstances and these medications' specifics.

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