Novalgin (1g/2ml) 3 Ampoule Injections

Metamizole sodium, commonly known as dipyrone, primarily exerts its analgesic and antipyretic effects through a central mechanism. It acts by inhibiting prostaglandin synthesis, reducing the production of inflammatory mediators. The drug also modulates nociceptive pathways in the central nervous system, likely by interacting with serotonin and opioid receptors, thereby elevating the pain threshold and reducing fever. Additionally, metamizole exhibits spasmolytic properties, which may contribute to its overall analgesic effect.

Non-opioid analgesic.

Injection

The following are the uses of Metamizole sodium injection:

• Used for rapid pain relief in cases of moderate to severe pain, such as post-operative pain, traumatic pain, and pain associated with cancer.
• Used for reducing fever and managing high body temperature in various conditions like infections, inflammatory diseases, and heatstroke.
• Used for treating severe migraine attacks to provide quick relief from headache and associated symptoms.
• Used for easing discomfort during diagnostic procedures or surgeries by providing short-term sedation and relaxation.
• Used for managing pain and inflammation in musculoskeletal disorders, including rheumatoid arthritis and ankylosing spondylitis.
• Used for alleviating pain and discomfort in renal colic or ureteric colic episodes.
• Used for controlling pain and reducing inflammation in gynecological conditions such as dysmenorrhea (painful periods).

In the case of an overdose of Metamizole sodium injection, it is important to recognize the potential severity of the situation. Symptoms may include severe drowsiness, difficulty breathing, rapid heartbeat, and even loss of consciousness. Immediate action is required, such as contacting a healthcare professional or a poison control center for guidance. They can provide specific instructions for managing the overdose, which may include supportive care and monitoring vital signs until the effects of the medication wear off.

In the case of a missed dose of Metamizole sodium injection, it is important to administer the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare professional for guidance on how to safely resume your medication regimen. It is crucial to maintain a consistent dosing schedule for optimal pain management and to prevent any potential complications.

To administer the Metamizole sodium injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and slowly inject the prescribed dose, ensuring the entire medication is delivered as directed by your healthcare provider.

Following are the conditions/situations when Metamizole sodium injection should not be used:

• Should not be administered to patients with a known allergy or hypersensitivity to Metamizole sodium or other pyrazolone derivatives.
• Contraindicated in patients with a history of agranulocytosis or bone marrow suppression caused by Metamizole.
• Not suitable for individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency due to the risk of hemolysis.
• Should not be used in patients with severe heart, liver, or kidney disease.
• Contraindicated in patients with acute porphyria.
• Not recommended for children under 12 years of age.
• Should be avoided during the last trimester of pregnancy and in breastfeeding mothers.
• Must not be used in patients with a history of asthma, hives, or other respiratory disorders triggered by analgesics.
• Should not be administered to individuals with active peptic ulcers or gastrointestinal bleeding.
• Contraindicated in patients with a history of seizures or conditions that lower the seizure threshold.

The side effects of Metamizole sodium injection may include:

• Skin reactions such as rash, itching, or hives.
• Dizziness or a feeling of lightheadedness.
• Nausea and vomiting.
• Stomach pain or discomfort.
• Diarrhea.
• Headache.
• Allergic reactions, including anaphylaxis (a severe, life-threatening reaction).
• Agranulocytosis (a severe decrease in white blood cells).

Following are the precautions and warnings for Metamizole sodium injection:

• Not recommended for individuals with known hypersensitivity or allergy to Metamizole sodium or any of its excipients.
• Should be used with caution in patients with impaired liver or kidney function, as dosage adjustments may be necessary.
• May cause dizziness or drowsiness, so patients should avoid driving or operating heavy machinery until the effects are known.
• Not recommended for long-term use; prolonged use may increase the risk of adverse effects.
• Elderly patients may be more susceptible to side effects, and careful monitoring is advised.
• Not recommended for use during pregnancy and breastfeeding unless the potential benefits outweigh the risks.
• Discontinue use and seek medical attention if symptoms such as skin rash, itching, or breathing difficulties occur, as these may indicate a severe allergic reaction.

Following are the drug interactions for Metamizole sodium injection:

• May interact with other non-steroidal anti-inflammatory drugs (NSAIDs) and increase the risk of gastrointestinal bleeding and kidney problems.
• Concomitant use with anticoagulants like warfarin can enhance bleeding risk.
• Should be used cautiously with other central nervous system (CNS) depressants, including alcohol, as it may cause excessive drowsiness.
• Potentially interacts with certain antibiotics like sulfonamides, increasing the risk of agranulocytosis.
• May affect the action of diuretics and antihypertensive medications, altering blood pressure control.
• Metamizole can increase the effects of lithium, leading to potential lithium toxicity.
• Caution is advised when using with drugs that affect liver metabolism, as it may impact the breakdown of Metamizole.

Following are the food interactions for Metamizole sodium injection:

• Alcohol consumption should be avoided as it can increase the risk of gastrointestinal bleeding and liver toxicity when combined with Metamizole sodium.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of the drug, potentially leading to increased blood levels and prolonged effects.
• Foods rich in vitamin K, like leafy green vegetables, should be consumed in moderation as Metamizole sodium can interfere with blood clotting.
• Avoid high-sodium foods as the injection already contains sodium, and excessive intake may lead to fluid retention and increased blood pressure.
• Limit caffeine intake as it can increase the risk of nervous system side effects when combined with Metamizole sodium.
• Avoid consuming large amounts of fatty foods as they may affect the absorption and distribution of the medication.
• Always follow dietary recommendations provided by your healthcare professional to ensure the safe and effective use of Metamizole sodium injection.

Metamizole sodium injection should be stored in a controlled environment, preferably in a cool and dry place with a temperature between 15-25°C (59-77°F). Protect it from direct sunlight, extreme heat, and freezing conditions as these can degrade the medication. Always keep the injection in its original packaging, ensuring the seal is intact, to maintain its sterility. When disposing of unused or expired injections, do not throw them into the regular trash or pour them down the drain. Contact your local waste management authorities or healthcare provider for guidance on proper disposal methods to minimize environmental impact. Keep this medication out of the reach of children and pets to prevent accidental exposure.

Following are the quick tips for Metamizole Sodium Injection:

• Ensure the injection is administered by a trained healthcare professional.
• Verify the correct dosage and injection site as directed by your doctor.
• Before injection, clean the injection site with an antiseptic solution.
• Insert the needle at a 90-degree angle and inject the solution slowly.
• After injection, apply gentle pressure with a sterile gauze pad to prevent bleeding.
• Dispose of used needles and syringes safely in a designated sharps container.
• If you experience pain, redness, or swelling at the injection site, inform your doctor promptly.