Novidat (250mg/5ml) 60ml Suspension

Ciprofloxacin, a potent broad-spectrum antibiotic from the fluoroquinolone class, is widely utilized in treating diverse bacterial infections. Its effectiveness stems from a multi-step mechanism of action. First, it easily penetrates bacterial cell membranes, binding to receptors on DNA gyrase and topoisomerase IV enzymes crucial for cell wall synthesis and DNA replication. Next, Ciprofloxacin inhibits DNA gyrase, preventing the formation of the DNA cleavable complex, thereby impeding DNA replication and repair. Simultaneously, it inhibits topoisomerase IV, disrupting the relaxation of supercoiled DNA necessary for cell division. This dual inhibition prevents bacterial cell division and proliferation. As the bacterial cell persists in attempting division, it accumulates DNA damage, including single-stranded breaks, leading to cell death and the ultimate eradication of the infection. Ciprofloxacin demonstrates remarkable efficacy against gram-negative bacteria like Escherichia coli and Pseudomonas aeruginosa.

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Quinolone

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Syrup/Suspension

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Unveiling its multifaceted uses and transformative applications as follows:

• Treatment of severe diarrhea caused by invasive strains of Salmonella typhimurium and Shigella.
• Treatment of acute febrile neutropenia caused by Escherichia coli and Klebsiella pneumonia.
• Treatment of pneumonia.
• Treatment of persistent urinary tract infections, chronic prostatitis, and sinusitis.
• Treatment of uncomplicated gonorrhea in adults and children 2 years and older.
• Treatment of skin and soft tissue infections.

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Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Acute bacterial sinusitis- 250mg once every 24 hours for 5 days, or 500mg once daily for 10 days.
• Community-acquired pneumonia- 500mg once every 24 hours for 7-14 days.
• Pharyngitis/tonsillitis/laryngitis- 250mg once every 24 hours for 7 days.
• Skin and skin structure infections- 250mg once every 24 hours for 14 days.
• UTIs- 250mg once every 24 hours for 7-14 days.

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An overdose of ciprofloxacin must be treated as an medical emergency, urgently requiring medical attention. Such treatment may include supportive care, focusing on reducing the symptoms of the overdose and monitoring for any potential complications. In some cases, dialysis is provided to help eliminate the drug from the body, though its efficacy is uncertain. With regards to oral intake, activated charcoal is occasionally administered to minimize the absorption of the drug from the gastrointestinal tract. However, this solution is only effective if implemented within a certain timeframe following the overdose. Unfortunately, the charcoal also absorbs the medication intended to treat the overdose. The most effective treatment plan will depend on the unique symptoms and conditions of the patient. Consequently, it is best to consult with a medical professional for proper treatment guidance and monitoring.

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Maintaining a regular medication schedule is crucial, especially when it comes to antibiotics like ciprofloxacin. Nevertheless, if you miss a dose, you can take it as soon as possible. However, if you're close to your next scheduled dose, it's safer to skip the missed dose and return to your regular schedule. Doubling up on or taking extra ciprofloxacin can lead to an overdose or unpleasant side effects. If you're concerned about missing a dose or need more information, consult a doctor or pharmacist for professional guidance. They can provide personalized advice based on your specific situation.

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When taking Ciprofloxacin 250mg/5ml, it is crucial to follow your doctor's instructions carefully and adhere to the prescribed dosage. It should be taken with a large glass of water to avoid the tablet from getting stuck in the esophagus. It is recommended to take the medication on an empty stomach, preferably at least one hour before or two hours after a meal. However, if you experience stomach upset, you may take it with food. It is important to swallow the tablet whole and not crush or chew it, as it is designed to be swallowed whole. To ensure the effectiveness of the medication, it should be stored at room temperature ranging from 68°F to 77°F (20°C to 25°C). The medication should be kept in a cool, dry place, away from heat, direct sunlight, and moisture. These instructions serve as a general guide. It is important to always follow the specific instructions and precautions provided to you by your doctor as directions may vary depending on your condition, concurrent medications, and other factors.

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Discerning instances where this medication may not be appropriate:

• You should not take Ciprofloxacin 250mg/5ml if you are allergic to ciprofloxacin or any of the other ingredients in this medication.
• You should also avoid taking this medication if you have ever had an allergic reaction to any other fluoroquinolone antibiotic.
• Following is a list of fluoroquinolone antibiotic:
   1. Levofloxacin (Levaquin) 
   2. Enoxacin
   3. Gatifloxacin (Tequin)
   4. Gemifloxacin
   5. Lexifloxacin
   6. Norfloxacin
   7. Ofloxacin
   8. Pefloxacin
   9. Penicillin
   10. Telithromycin

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Unraveling the side effects lurking behind this medications are as follows:

• Diarrhea
• Vomiting
• Nausea
• Loss of appetite
• Asthenia (physical fatigue)
• Headaches
• Insomnia
• Dermatitis (skin reactions)
• Chest discomfort
• Muscle pain

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The warnings and precautions associated with Ciprofloxacin are:

• Patient with known or suspected CNS disorders, risk factors predisposing to seizures, or lower seizure threshold.
• History or risk factors for QT interval prolongation, torsades de pointes, uncorrected hypokalaemia/hypomagnesaemia, cardiac disease (e.g., heart failure, MI, bradycardia).
• Positive family history of aneurysm disease.
• Pre-existing aortic aneurysm or dissection and its risk factors (e.g., Marfan syndrome, vascular Ehlers-Danlos syndrome, hypertension, peripheral atherosclerotic vascular disease).
• Diabetes.
• Previous tendon disorder (e.g., rheumatoid arthritis).
• G6PD deficiency.
• Renal and hepatic impairment.
• Elderly and children.
• Pregnancy and lactation.
• Immunocompromised febrile neutropenic patients.
• Not recommended for streptococcal or gonococcal infections in some countries due to resistance.
• Not effective in treating syphilis.
• Reserved for cases like acute bronchitis, cystitis, or sinusitis when no alternative options exist.

The drug interactions with ciprofloxacin include:

• Antacids (containing aluminum, magnesium) – Ciprofloxacin absorption can be reduced when taken with antacids.
• Warfarin – Ciprofloxacin can enhance the effects of warfarin, increasing the risk of bleeding.
• Theophylline – Ciprofloxacin can increase the levels of theophylline, potentially leading to toxicity.
• Caffeine – Ciprofloxacin may increase the effects of caffeine, potentially leading to increased side effects.
• CYP1A2 Substrates (e.g., clozapine, tizanidine) – Ciprofloxacin can increase the levels of drugs metabolized by CYP1A2, leading to potential side effects.
• Methotrexate – Ciprofloxacin may increase methotrexate levels, increasing the risk of toxicity.
• Probenecid – Probenecid can increase ciprofloxacin levels by inhibiting its renal excretion.
• Cyclopropane – Ciprofloxacin can enhance the effects of cyclopropane, increasing the risk of seizures.
• Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) – Combining ciprofloxacin with NSAIDs can increase the risk of central nervous system stimulation and seizures.
• Antiarrhythmic Drugs (e.g., quinidine, sotalol) – Ciprofloxacin may increase the risk of QT interval prolongation when used with antiarrhythmics.

The food interactions that should be considered while using Ciprofloxacin are:

• Avoid taking with dairy products as calcium can interfere with absorption.
• Taking with food may reduce gastrointestinal upset.

Ciprofloxacin is a medication that needs to be stored in a specific way to maintain its effectiveness. Upon purchasing the medication, it is important to inquire about the proper storage techniques from your pharmacist or doctor. This drug is typically provided in liquid form and should be stored in a cool, dry place away from any direct heat or light. For optimum preservation, the temperature should be maintained between 2°C and 8°C (36°F and 46°F) and prevented from freezing. Moreover, the container should be tightly closed and stored in a cabinet or drawer away from sunlight and moisture.For safety purposes, it is crucial to keep ciprofloxacin out of the reach of children and pets to avoid accidental consumption. It is advised to avoid storing the medication in areas such as the bathroom or kitchen, as these spaces may have humid and warm temperatures. Should you have any questions or concerns about storing ciprofloxacin, it is recommended to consult your pharmacist or doctor for further guidance. They will be able to provide you with adequate instructions and information to ensure the safety and quality of your medication.

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Drink plenty of fluids while taking ciprofloxacin to help prevent kidney issues.

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