Novirep (2mg) 30 Tablets

Repaglinide, a medication commonly found in 2MG tablets, acts as a potent insulin secretagogue, meaning it stimulates the release of insulin from the pancreas. Its mechanism of action involves blocking ATP-sensitive potassium channels in the pancreatic beta cells. By inhibiting these channels, repaglinide induces a rapid and significant increase in intracellular calcium, leading to insulin secretion. This process is glucose-dependent, meaning it occurs primarily when blood glucose levels are elevated, mimicking the body's natural response to rising blood sugar. This targeted action makes repaglinide an effective agent in managing type 2 diabetes, helping to control blood glucose levels without the risk of inducing hypoglycemia in normal subjects.

Meglitinide analogues.

Tablet

The following are the uses of Repaglinide 2MG Tablet:

• Used for treating type 2 diabetes when diet and exercise alone are not effective in controlling blood sugar levels.
• Used to stimulate the pancreas to release insulin, helping to lower blood glucose.
• Used to manage blood sugar spikes after meals, improving overall glucose control.
• Used to enhance insulin production at mealtimes, preventing post-meal hyperglycemia.
• Used for patients who struggle with managing blood sugar levels through diet and lifestyle alone.
• Used as a short-acting insulin secretagogue, providing rapid response after consumption.
• Used in combination with other diabetes medications for better blood sugar control.

In the case of an overdose of Repaglinide 2MG Tablets, prompt medical attention is necessary. Symptoms may include severe hypoglycemia, characterized by dizziness, sweating, confusion, and rapid heartbeat. It is important to seek emergency help and inform medical professionals about the specific medication and dosage taken. Quick action can help manage the overdose and prevent potential complications, ensuring the patient's safety and well-being.

In the case of a missed dose of Repaglinide 2MG Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Never double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen.

To take Repaglinide 2MG Tablet, swallow the tablet whole with a glass of water, preferably before a meal, following the dosage instructions provided by your healthcare professional, typically taken 30 minutes before a meal, and the dosage may be adjusted based on your blood sugar levels and response to the medication.

Following are the conditions when Repaglinide 2MG Tablet should not be taken:

• Should not be used in individuals with a known allergy to Repaglinide or related drugs.
• Not suitable for patients with type 1 diabetes mellitus or diabetic ketoacidosis.
• Contraindicated in patients with severe liver disease.
• Should not be used if you have a severe infection or are experiencing physical stress.
• Not recommended for individuals with a history of heart disease or those who have recently had a heart attack.
• Avoid using this medication if you have a severe injury or are recovering from major surgery.
• Do not take this medication if you have a condition called hemolytic anemia (a breakdown of red blood cells).
• Contraindicated in individuals with a history of diabetic lactic acidosis.

The side effects of Repaglinide 2MG Tablet may include:

• Hypoglycemia (low blood sugar)
• Weight gain
• Headache
• Nausea and vomiting
• Diarrhea
• Joint pain
• Dizziness
• Skin rash

Following are the precautions and warnings for Repaglinide 2MG Tablet:

• This medication is intended for patients with type 2 diabetes and should not be used by individuals with type 1 diabetes or diabetic ketoacidosis.
• Patients with liver or kidney disease should use this medication with caution as it is metabolized by the liver and excreted by the kidneys. Regular monitoring of liver and kidney function is recommended.
• Repaglinide can cause hypoglycemia (low blood sugar). Be aware of the symptoms and always carry a source of glucose (such as glucose tablets or juice) to treat low blood sugar.
• It is important to maintain a consistent carbohydrate diet and regular meal schedule while taking this medication. Skipping meals or changing diet patterns may affect blood sugar levels.
• Alcohol consumption may increase the risk of hypoglycemia or hyperglycemia. It is advisable to limit or avoid alcohol while on this medication.
• Inform your doctor if you have a history of heart disease as this medication may have cardiovascular effects.
• Repaglinide may cause weight gain, so regular monitoring of weight and overall health is recommended.
• This medication should be used with caution in the elderly as they may be more sensitive to its effects, especially hypoglycemia.

Following are the drug interactions for Repaglinide 2MG Tablet:

• Concomitant use with gemfibrozil can significantly increase repaglinide exposure, leading to hypoglycemia. Dose adjustment may be required.
• CYP3A4 inducers like rifampicin reduce the efficacy of repaglinide by decreasing its blood levels. Consider alternative medications.
• Antifungal agents such as ketoconazole, which are CYP3A4 inhibitors, can increase repaglinide levels, thus enhancing its blood-glucose-lowering effect.
• Combining with beta-blockers may mask the symptoms of hypoglycemia, especially non-cardioselective beta-blockers. Regular monitoring is advised.
• Consumption of alcohol may potentiate the hypoglycemic effect of repaglinide, leading to more severe and prolonged episodes.
• Certain antibiotics, such as clarithromycin, can increase repaglinide levels, thus enhancing its glucose-lowering effect.
• Repaglinide may increase the concentration of HMG-CoA reductase inhibitors (statins), increasing the risk of myopathy and rhabdomyolysis.

Following are the food interactions for Repaglinide 2MG Tablet:

• Avoid consuming grapefruit and grapefruit juice as they can significantly increase the drug's blood levels, potentially leading to hypoglycemia.
• Alcohol intake should be monitored as it can increase the risk of side effects and may interfere with blood sugar control.
• Avoid high-fat meals as they can decrease the absorption and effectiveness of Repaglinide.
• Consuming garlic may increase the risk of bleeding and should be limited.
• Ginger, a common spice, can lower blood sugar and enhance the effects of Repaglinide.
• Fish oil supplements might influence blood sugar levels and should be used cautiously.
• Fenugreek, a herbal supplement, can also lower blood sugar and may require dosage adjustments.
• No significant food interactions are known to affect the drug's absorption, but always follow your healthcare provider's instructions.

Repaglinide 2MG Tablets should be stored in a cool and dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Protect the tablets from excessive heat, moisture, and direct sunlight as these conditions can degrade the medication. Always keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to external factors. Do not use the medication if there are signs of tampering or if the packaging appears damaged. When disposing of unused or expired tablets, do not throw them into the trash or flush them down the toilet. Consult your pharmacist or local waste disposal company for specific instructions on safe disposal methods to protect the environment.

Following are the quick tips for Repaglinide 2MG Tablet:

• Consult your doctor for the right dosage and duration based on your medical condition.
• Take the tablet by mouth, preferably before meals as directed.
• It is best to take it 30 minutes before a meal, but not more than 30 minutes before.
• If you skip a meal, you may need to skip the dose as well.
• Do not take a double dose to make up for a missed one.
• Inform your doctor about all medications you are taking to avoid drug interactions.
• Store the tablets in a cool, dry place away from direct sunlight.