NUKIK TAB

Nicotinic Acid, also known as niacin, primarily exerts its therapeutic effects through its interaction with specific receptors in the body. The mechanism of action involves the activation of G-protein-coupled receptors, particularly the GPR109A and GPR109B receptors, which are widely expressed in various tissues. Upon binding to these receptors, nicotinic acid triggers a cascade of intracellular signaling events. One crucial effect is the inhibition of lipolysis in adipose tissue, leading to reduced release of free fatty acids. This action contributes to the decrease in plasma triglyceride levels, making nicotinic acid effective in managing dyslipidemia. Additionally, nicotinic acid stimulates the production of HDL (high-density lipoprotein) cholesterol, often referred to as "good cholesterol," further enhancing its lipid-modifying properties. By modulating these receptor-mediated pathways, nicotinic acid plays a significant role in improving lipid profiles and managing conditions associated with abnormal lipid metabolism.

Fibrate.

Tablet

The following are the uses of Nicotinic Acid Tablet:

• Used for treating high cholesterol and triglyceride levels in the blood.
• Used to increase HDL (good) cholesterol levels.
• Used to reduce the risk of heart disease and improve cardiovascular health.
• Used to manage pellagra, a vitamin deficiency disease.
• Used to treat deficiency of niacin, especially in alcoholics.
• Used for managing skin conditions like bullous pemphigoid and granuloma annulare.
• Used as a treatment for diarrhea in patients with HIV/AIDS.
• Used to improve blood circulation and reduce symptoms of claudication (leg pain while walking).

In the case of an overdose of Nicotinic Acid Tablets, it is important to recognize the signs and symptoms, which may include flushing, headache, dizziness, and gastrointestinal issues. Promptly seek medical advice or call a poison control center for guidance. Treatment may involve managing symptoms and providing supportive care to ensure the patient's well-being. Timely intervention can help mitigate the potential risks associated with an overdose.

In the case of a missed dose of Nicotinic Acid Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare provider for guidance on how to get back on track with your medication regimen.

To take Nicotinic Acid Tablets, swallow the tablet whole with a full glass of water, preferably after a meal, following the prescribed dosage instructions provided by your healthcare professional, which may vary based on your medical condition and response to treatment.

Following are the conditions/situations when Nicotinic Acid Tablet should not be used:

• Should not be used in individuals with a known allergy or hypersensitivity to nicotinic acid or any of its excipients.
• Contraindicated in patients with liver disease, as it can worsen liver function.
• Not recommended for individuals with active peptic ulcer disease, as it may cause gastrointestinal irritation.
• Should be avoided in patients with gout, as it can increase uric acid levels.
• Not suitable for individuals with a history of diabetes, as it may affect blood sugar control.
• Contraindicated in patients with a history of bleeding disorders or those taking anticoagulant medications.
• Should not be used in individuals with a recent history of heart attack or unstable angina.
• Not recommended for patients with untreated hypothyroidism.
• Should be used with caution in individuals with kidney disease and monitored closely.
• Avoid using in pregnant or breastfeeding women unless clearly needed and under medical supervision.

The side effects of Nicotinic Acid Tablet may include:

• Flushing or redness of the skin, especially on the face and neck.
• Itching or tingling sensation.
• Nausea and vomiting.
• Stomach pain and cramps.
• Diarrhea or constipation.
• Headaches and dizziness.
• Increased blood sugar levels (hyperglycemia).
• Liver function abnormalities.

Following are the precautions and warnings for Nicotinic Acid Tablet:

• Not suitable for individuals with a known hypersensitivity or allergy to nicotinic acid or related compounds.
• Patients with a history of liver disease should exercise caution and undergo regular liver function tests as nicotinic acid can affect liver function.
• May cause flushing, itching, and gastrointestinal disturbances; these are generally mild and transient but should be monitored.
• Patients with diabetes should be cautious as nicotinic acid can affect blood sugar levels. Regular monitoring of blood glucose is necessary.
• Nicotinic acid may cause a temporary rise in blood uric acid levels, so patients with gout or a history of gout should be closely monitored.
• This medication can impact the results of certain medical tests, so inform your doctor if you are scheduled for any tests.
• The safety and effectiveness of Nicotinic Acid Tablet in children have not been established, and its use in pediatric patients should be guided by a healthcare professional.

Following are the drug interactions for Nicotinic Acid Tablet:

• Alcohol may increase the risk of liver-related side effects when used with nicotinic acid.
• Nicotinic acid can increase blood sugar levels, so monitoring is necessary when used with diabetes medications.
• Statins and nicotinic acid together may increase the risk of muscle-related side effects.
• Anticoagulants like warfarin may have their effects enhanced, requiring close monitoring.
• Gemfibrozil can increase the risk of nicotinic acid side effects, especially on the liver.
• The effectiveness of antihypertensive drugs may be reduced by nicotinic acid.
• Corticosteroids may increase the risk of metabolic side effects when used concurrently.

Following are the food interactions for Nicotinic Acid Tablet:

• Avoid excessive alcohol consumption as it can increase the risk of liver problems and may interact with Nicotinic Acid, causing flushing and other side effects.
• Limit high-fat and cholesterol-rich foods as Nicotinic Acid is used to treat high cholesterol, and dietary changes are essential for managing the condition effectively.
• Avoid grapefruit and grapefruit juice, as they can interfere with the metabolism of Nicotinic Acid, leading to increased blood levels and potential side effects.
• Do not consume hot beverages immediately after taking the tablet to prevent irritation or discomfort in the mouth or throat.
• Avoid spicy foods as they may exacerbate flushing, a common side effect of Nicotinic Acid.
• Ensure a balanced diet rich in fruits, vegetables, and whole grains to support overall health and the medication's effectiveness.
• Stay well-hydrated by drinking plenty of water throughout the day, especially when taking Nicotinic Acid tablets.

Nicotinic Acid Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. It is crucial to keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent exposure to external contaminants. Avoid storing them in bathrooms or areas with high humidity, as moisture can impact their effectiveness. Always adhere to the expiration date printed on the packaging, and properly dispose of any unused or expired tablets. Do not dispose of them by flushing or pouring them into drainage systems; instead, seek guidance from a pharmacist or healthcare professional for appropriate disposal methods. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Nicotinic Acid Tablet:

• Consult your doctor before taking this medication for personalized advice.
• Swallow the tablet whole without crushing or chewing for optimal absorption.
• Take the tablet with a full glass of water to aid in swallowing and digestion.
• Avoid cutting or breaking the tablet unless advised by your doctor.
• Maintain a consistent schedule for taking the medication as directed.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Inform your healthcare provider about all medications you are taking to prevent potential interactions.
• Contact your doctor if you experience any side effects or unusual symptoms.