NUPRIDE 50MG TAB

Cisapride's primary mechanism of action involves enhancing gastrointestinal motility. It acts as an agonist at serotonin 5-HT4 receptors in the gastrointestinal tract, stimulating the release of acetylcholine, which in turn activates intestinal smooth muscle and increases peristalsis. This action accelerates gastric emptying, increases the frequency of bowel movements, and improves gastrointestinal transit time. By facilitating the movement of food and digestive contents through the gut, Cisapride helps alleviate symptoms associated with gastrointestinal motility disorders, such as gastroesophageal reflux disease (GERD) and certain types of constipation.

Cisapride 50MG

Prokinetic agent.

Tablet

The following are the uses of Cisapride 50MG Tablet:

• Used for treating heartburn and gastroesophageal reflux disease (GERD).
• Used for speeding up stomach emptying in patients with delayed gastric emptying (gastroparesis).
• Used to relieve symptoms of nausea and vomiting.
• Used to improve gastrointestinal motility in conditions like diabetic gastroparesis.
• Used for treating constipation-predominant irritable bowel syndrome (IBS-C).
• Used to enhance intestinal motility, especially in post-operative patients.
• Used for managing symptoms of dyspepsia and indigestion.
• Used to promote bowel movements and alleviate bloating.

In the case of an overdose of Cisapride 50MG Tablet, individuals may experience an exacerbation of typical side effects, including nausea, diarrhea, and abdominal pain. Additionally, more severe symptoms such as rapid heartbeat, fainting, and chest pain may occur. It is important to seek medical advice immediately, as prompt intervention can help manage these symptoms and prevent potential complications. Quick action can ensure the best possible outcome in such situations.

In the case of a missed dose of Cisapride 50MG Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to restart the medication or provide alternative instructions. It is crucial to maintain a consistent dosing routine for the medication's effectiveness.

To take the Cisapride 50MG Tablet, swallow the tablet whole with a full glass of water, preferably before a meal, as directed by your healthcare professional, typically twice a day, 15 to 30 minutes before meals.

Here are the circumstances under which Cisapride 50MG Tablet should not be taken:

• Not suitable for individuals with a known hypersensitivity or allergy to Cisapride or related compounds.
• Should not be used in patients with a prolonged QT interval or a history of irregular heart rhythms.
• Contraindicated in individuals with a history of heart disease, such as congestive heart failure or recent heart attack.
• Not recommended for patients with gastrointestinal bleeding or obstruction.
• Avoid using in patients with severe kidney or liver impairment.
• Should not be administered to children under 16 years of age.
• Contraindicated during pregnancy and breastfeeding.

The side effects of Cisapride 50MG Tablet may include:

• Diarrhea
• Headache
• Dizziness
• Nausea
• Abdominal pain
• Skin rash
• Cardiac arrhythmias
• Increased risk of heart-related complications

Following are the precautions and warnings for Cisapride 50MG Tablet:

• Not recommended for patients with a history of cardiac arrhythmias or those currently experiencing irregular heartbeats, as it may worsen these conditions.
• Patients with a history of liver disease should exercise caution and undergo regular liver function tests while on this medication.
• Cisapride may interact with other medications, including antifungal drugs and certain antibiotics; consult your doctor before combining it with other treatments.
• Avoid alcohol consumption while taking this medication, as it may increase the risk of adverse effects.
• Not suitable for pregnant or breastfeeding women; consult your doctor for alternative options.
• Elderly patients may be more susceptible to side effects; close monitoring is advised.
• Discontinue use and seek medical attention if symptoms such as severe diarrhea, abdominal pain, or irregular heartbeat occur.

Following are the drug interactions for Cisapride 50MG Tablet:

• Cisapride can interact with macrolide antibiotics (e.g., erythromycin, clarithromycin), leading to increased cisapride levels and potential cardiac arrhythmias.
• Concomitant use with azole antifungals (e.g., ketoconazole, itraconazole) may result in elevated cisapride concentrations and increased risk of adverse effects.
• Cisapride should not be taken with certain antidepressants, including tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs), due to the risk of cardiac arrhythmias.
• It can interact with calcium channel blockers (e.g., verapamil, diltiazem), increasing cisapride levels and the risk of cardiac toxicity.
• Cisapride may enhance the effects of H2-receptor antagonists (e.g., ranitidine, cimetidine), potentially leading to prolonged QT intervals.
• The combination with certain antihistamines (e.g., astemizole, terfenadine) is contraindicated due to the risk of ventricular arrhythmias.
• Cisapride may increase the bioavailability of digoxin, requiring careful monitoring of digoxin levels.

Following are the food interactions for Cisapride 50MG Tablet:

• Consumption of grapefruit or grapefruit juice should be avoided as it may inhibit the enzyme CYP3A4, leading to increased levels of Cisapride in the bloodstream and potentially causing adverse effects, particularly cardiac complications.
• Alcohol intake is not recommended as it can enhance the sedative properties of Cisapride, increasing the risk of side effects like dizziness and drowsiness.
• High-fat meals may slightly delay the absorption of Cisapride, but it does not significantly impact its overall effectiveness.
• Avoid caffeine-rich foods and beverages as Cisapride may enhance the effects of caffeine, potentially leading to increased heart rate and blood pressure.
• Avoid eating large quantities of ginger, as it may interact with Cisapride and affect gastrointestinal motility.
• Avoid excessive consumption of chocolate, as it contains methylxanthines, which can interact with Cisapride and potentially cause cardiac issues.
• It is advisable to maintain a balanced diet and avoid excessive consumption of any specific food group while taking Cisapride to minimize potential interactions.
• Always consult your healthcare provider for personalized advice regarding dietary restrictions and interactions.

Cisapride 50MG Tablets should be stored in a cool, dry area, ideally at room temperature, ensuring protection from direct sunlight and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. It's crucial to avoid placing them in the bathroom or near heat sources like ovens or radiators, as temperature fluctuations can impact their effectiveness. Dispose of any unused or expired tablets responsibly; refrain from flushing them or pouring them down the drain. Consult your pharmacist or healthcare professional for appropriate disposal methods. Remember to keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Cisapride 50MG Tablet:

• Consult a doctor before use if you have any medical conditions or are taking other medications.
• Swallow the tablet whole, do not crush or chew.
• Take the tablet with a full glass of water, preferably at the same time each day.
• Avoid grapefruit and grapefruit juice as they may interact with the medication.
• Do not drive or operate machinery until you know how the medication affects you.
• Inform your doctor if you experience any unusual or severe side effects.
• Store the medication in a cool, dry place, away from direct sunlight.