Odenil (40mg) 100 Tablets

Furosemide, a potent loop diuretic, primarily acts by inhibiting the reabsorption of sodium and chloride ions in the ascending loop of Henle in the kidneys. It achieves this by binding to and inhibiting the Na-K-2Cl cotransporter, which is responsible for the active transport of these ions from the lumen of the nephron back into the bloodstream. By blocking this transporter, furosemide promotes the excretion of sodium, chloride, and water, leading to increased diuresis and a reduction in extracellular fluid volume. This mechanism is particularly effective because the loop of Henle is responsible for a significant portion of the sodium reabsorption in the nephron, and by targeting this segment, furosemide exerts a powerful diuretic effect. The increased delivery of sodium to the distal tubule also enhances potassium excretion, which is a secondary effect of the drug's action.

Furosemide 40mg

Loop Diuretic

Tablet

The following are the uses of Furosemide 40mg Tablet:

• Used for treating fluid retention (edema) in various medical conditions such as heart failure, liver disease, and kidney disease.
• Used for reducing excess fluid buildup, which helps to lower blood pressure and improve breathing.
• Used for managing hypertension, helping to control high blood pressure and prevent complications.
• Used for rapid fluid removal in emergency situations, such as pulmonary edema.
• Used for treating certain types of kidney disorders, aiding in maintaining proper kidney function.
• Used for reducing swelling and discomfort in conditions like lymphedema or idiopathic cyclic edema.
• Used for managing electrolyte imbalances, particularly when there is excess fluid retention.
• Used for preparing patients for certain medical procedures by reducing fluid levels.

In the case of an overdose of Furosemide 40mg Tablets, symptoms may include excessive urination, dehydration, electrolyte imbalances, and potential hearing changes. Individuals may experience dizziness, lightheadedness, and a drop in blood pressure. Promptly seek medical advice if an overdose is suspected, as treatment may involve managing symptoms and providing supportive care. It is crucial to act quickly and consult healthcare professionals to ensure the best possible outcome.

In the case of a missed dose of Furosemide 40mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track. It's crucial to maintain consistency with this medication, so ensure you take it at the same time each day.

To take Furosemide 40mg Tablet, swallow the tablet whole with a glass of water, preferably in the morning or as directed by your healthcare provider, without crushing or chewing it.

Here are the conditions or situations when Furosemide 40mg Tablet should not be taken:

• Avoid using if you have an allergy to Furosemide or other sulfa drugs.
• Do not take if you are experiencing dehydration or have low blood volume.
• Contraindicated in patients with severe kidney disease or those who are not producing urine.
• Should not be used if you have severe liver disease or liver failure.
• Avoid using if you have low potassium or sodium levels in your blood.
• Not recommended for individuals with gout or a history of gout.
• Do not use if you have a history of hearing loss or tinnitus associated with diuretic use.
• Contraindicated during pregnancy, especially in the first trimester, unless the potential benefits outweigh the risks.
• Should not be used by breastfeeding mothers due to potential risks to the infant.
• Avoid if you have a history of severe blood clots or a blood clotting disorder.

The side effects of Furosemide 40mg Tablet may include:

• Increased urination
• Dehydration
• Electrolyte imbalances (low potassium, sodium, or magnesium levels)
• Muscle cramps
• Fatigue or weakness
• Dizziness or lightheadedness
• Hypotension (low blood pressure)
• Hearing changes or ringing in the ears

Following are the precautions and warnings for Furosemide 40mg Tablet:

• Not suitable for patients allergic to Furosemide or sulfonamide-derived drugs; an alternative medication should be considered.
• Regular monitoring of kidney function is essential, especially in elderly patients and those with pre-existing kidney issues.
• Electrolyte levels, particularly potassium, should be monitored as Furosemide can cause imbalances.
• Blood pressure should be regularly checked as it may cause hypotension.
• Patients with diabetes should be cautious as Furosemide can alter blood sugar levels.
• Avoid sudden standing or sitting up, especially in the elderly, due to the risk of orthostatic hypotension.
• Inform your doctor if you have liver disease, gout, or systemic lupus erythematosus before taking this medication.

Following are the drug interactions for Furosemide 40mg Tablet:

• Furosemide may reduce the effectiveness of blood pressure medications like ACE inhibitors and beta-blockers, requiring close monitoring.
• When used with other diuretics, such as thiazides or potassium-sparing diuretics, the risk of electrolyte imbalances, particularly hypokalemia, is increased.
• Furosemide can decrease the renal excretion of lithium, leading to potential lithium toxicity. Lithium levels should be monitored closely.
• It may interact with nonsteroidal anti-inflammatory drugs (NSAIDs), increasing the risk of kidney function impairment.
• Caution is advised when combining Furosemide with medications that can cause ototoxicity, such as certain antibiotics, as this may increase the risk of hearing damage.
• Furosemide may lower blood sugar levels, and its effect may be enhanced when used with antidiabetic medications, requiring close glucose monitoring.
• The use of Furosemide with corticosteroids or other drugs that deplete potassium can further lower potassium levels, necessitating potassium supplementation.

Following are the food interactions for Furosemide 40mg Tablet:

• Avoid excessive salt or sodium in your diet, as Furosemide is a diuretic and high sodium intake can reduce its effectiveness.
• Maintain a consistent level of potassium in your diet, as Furosemide can cause potassium loss. Include potassium-rich foods like bananas, oranges, and spinach.
• Limit your intake of foods rich in vitamin C, as high doses of vitamin C can reduce the effectiveness of Furosemide.
• Alcohol should be consumed in moderation, as it can increase the risk of dehydration and may interfere with the medication's diuretic effect.
• Avoid grapefruit and grapefruit juice, as they can affect the metabolism of Furosemide, potentially leading to increased drug levels in the body.
• Avoid or limit caffeine intake, as it can increase fluid loss and may exacerbate dehydration.
• Be cautious with a high-protein diet, as it may affect the excretion of Furosemide and its effectiveness.
• Always stay well-hydrated by drinking enough fluids, especially when taking Furosemide to prevent dehydration.

Furosemide 40mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet, at room temperature (around 25°C). Keep the tablets in their original container, ensuring the lid is tightly sealed to maintain their integrity and prevent exposure to moisture. It's crucial to keep this medication away from children and pets by storing it in a locked cabinet or out of their reach. Do not store the tablets in the bathroom or kitchen, as humidity and temperature fluctuations can impact their effectiveness. When disposing of unused or expired tablets, do not throw them in the trash or flush them down the toilet. Instead, consult your pharmacist or local waste management guidelines for safe disposal methods to protect the environment.

Following are the quick tips for Furosemide 40mg Tablet:

• Take the tablet as directed by your doctor, typically once or twice daily.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Maintain a consistent dosing schedule, preferably at the same time each day.
• Ensure you stay well-hydrated while taking this medication.
• Avoid sudden changes in diet, especially salt intake, during treatment.
• Regularly monitor your blood pressure and kidney function as advised by your doctor.
• Store the tablets in a cool, dry place, away from direct sunlight.