Oflobid (200mg) 100ml, 1 Vial Injection

Ofloxacin 200mg, a synthetic fluoroquinolone antibiotic, exerts its bactericidal effect by inhibiting DNA gyrase and topoisomerase IV, essential enzymes responsible for bacterial DNA replication, transcription, and repair. This inhibition leads to the disruption of DNA synthesis, causing bacterial cell death. Ofloxacin primarily targets the bacterial enzyme DNA gyrase, forming a stable drug-enzyme-DNA complex, which prevents DNA supercoiling and relaxation, essential for DNA replication and cell division. By interfering with these vital processes, Ofloxacin effectively kills susceptible bacteria, including both Gram-positive and Gram-negative organisms.

Quinolone antibiotic.

injection

The following are the uses of Ofloxacin 200mg injection:

• Used for treating severe bacterial infections such as pneumonia, skin infections, and urinary tract infections.
• Used in cases where oral administration is not possible or effective.
• Used to achieve rapid and high antibiotic concentrations in the body.
• Used for managing infections in critically ill patients or those with severe underlying conditions.
• Used to prevent and treat infections during surgical procedures.
• Used as an alternative therapy for patients allergic to other antibiotics.
• Used for infections caused by bacteria resistant to other antibiotics.
• Used in combination with other antibiotics for synergistic effects.

In the case of an overdose of Ofloxacin 200mg injection, it is important to act swiftly. Symptoms may include nausea, dizziness, and in severe cases, seizures. Seek medical assistance immediately and provide healthcare professionals with the dosage information. They will likely monitor vital signs and provide supportive care to manage any adverse effects. Prompt action is vital to minimize potential harm and ensure the best possible outcome.

In the case of a missed dose of Ofloxacin 200mg injection, it is important to administer the medication as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare professional for advice on how to proceed, as they may provide specific instructions based on your medical condition and treatment plan. It is crucial to maintain a consistent dosing regimen for the best therapeutic outcome.

To administer Ofloxacin 200mg injection, ensure the medication is at room temperature, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and slowly inject the entire contents of the vial into the muscle, followed by a gentle massage of the area.

Here are the conditions and situations when Ofloxacin 200mg injection should not be used:

• Avoid if you have a known allergy to Ofloxacin or any other quinolone antibiotics.
• Do not use if you are pregnant or breastfeeding, as it may harm the unborn child or infant.
• Should not be used in children and adolescents under 18 years of age, as their bones and joints are still developing.
• Contraindicated in patients with a history of tendon disorders or tendon rupture, especially those related to previous quinolone use.
• Not recommended for individuals with myasthenia gravis, as it may worsen muscle weakness.
• Avoid if you have epilepsy or other seizure disorders, as it may lower the seizure threshold.
• Do not use if you have central nervous system disorders or psychotic reactions in your medical history.
• Not suitable for patients with prolonged QT intervals or other heart-related issues.
• Should be avoided in individuals with kidney disease or impaired kidney function.
• Do not administer if you have diabetes, as it may affect blood glucose levels.

The side effects of Ofloxacin 200mg injection may include:

• Nausea and vomiting
• Diarrhea
• Headache
• Dizziness
• Skin rash or itching
• Sensitivity to sunlight (photosensitivity)
• Sleep disturbances
• Joint or muscle pain

Here are the precautions and warnings for Ofloxacin 200mg injection:

• Avoid using Ofloxacin if you have a known allergy to any quinolone antibiotics, as severe allergic reactions may occur.
• This medication can cause tendon damage or rupture, especially in individuals over 60 years old, those taking corticosteroids, and post-transplant patients. Discontinue use at the first sign of tendon pain or inflammation.
• Ofloxacin should be used with caution in patients with central nervous system disorders as it may worsen their condition.
• It may cause photosensitivity, so avoid excessive sunlight or UV light exposure during treatment.
• Patients with kidney or liver disease may require a dosage adjustment and should be monitored closely.
• The elderly population may be more susceptible to side effects, including tendon disorders and central nervous system effects.
• Ofloxacin should be used with caution in patients with myasthenia gravis as it may exacerbate muscle weakness.
• Discontinue use and seek medical attention if you experience signs of liver problems, such as jaundice, dark urine, or abdominal pain.

Following are the drug interactions for Ofloxacin 200mg injection:

• Theophylline and caffeine levels may be increased, leading to potential toxicity.
• When combined with non-steroidal anti-inflammatory drugs (NSAIDs), the risk of CNS stimulation and convulsive seizures may be elevated.
• Antacids containing magnesium or aluminum can reduce the absorption of Ofloxacin, thus decreasing its effectiveness.
• Probenecid may increase the concentration of Ofloxacin in the body, potentially enhancing its effects and side effects.
• Sucralfate can bind to Ofloxacin, reducing its absorption and effectiveness.
• The use of corticosteroids and Ofloxacin together may increase the risk of tendon rupture.
• Cimetidine can inhibit the metabolism of Ofloxacin, resulting in higher drug levels in the body.

Following are the food interactions for Ofloxacin 200mg injection:

• Avoid consuming dairy products like milk, yogurt, or cheese, as they can decrease the absorption of Ofloxacin, reducing its effectiveness.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of Ofloxacin, leading to increased drug levels in the body and potential side effects.
• Limit caffeine intake from coffee, tea, or energy drinks as it may enhance the side effects of Ofloxacin, causing increased nervousness, restlessness, and difficulty sleeping.
• Alcohol consumption should be minimized or avoided as it can increase the risk of Ofloxacin's side effects, particularly affecting the central nervous system and gastrointestinal tract.
• Avoid high-sugar foods and beverages as they can interfere with the absorption of Ofloxacin, and may promote the growth of certain bacteria, reducing the effectiveness of the medication.
• Ensure adequate hydration by drinking plenty of water during the course of Ofloxacin treatment to reduce the risk of certain side effects like kidney stones and crystal formation.
• Avoid iron-rich foods such as red meat, liver, and iron supplements. These can decrease the absorption of Ofloxacin, so it is best to separate their consumption by at least 2 hours.
• Maintain a balanced diet rich in fiber, lean proteins, and complex carbohydrates to support overall health and potentially reduce the severity of gastrointestinal side effects associated with Ofloxacin.

Ofloxacin 200mg injection should be stored in a controlled environment, preferably in a cool and dry place away from direct sunlight and moisture. Maintain a consistent room temperature, typically between 68°F to 77°F (20°C to 25°C), to ensure the stability of the medication. Keep the injection in its original packaging, tightly sealed, to prevent contamination and maintain its integrity. It is crucial not to store it in the bathroom or near heat-emitting appliances, as extreme temperatures can degrade the medication. Always adhere to the expiration date indicated on the packaging, and dispose of any unused or expired injections responsibly. Do not attempt to dispose of the medication by flushing it down the toilet or pouring it down the drain. Consult your pharmacist or healthcare provider for appropriate disposal guidelines. Additionally, ensure that the medication is stored securely, out of the reach of children, to prevent accidental exposure or ingestion.

Following are the quick tips for Ofloxacin 200mg injection:

• Ensure sterile conditions and use a new needle for each injection.
• Inject the medication slowly as directed by your healthcare professional.
• Rotate injection sites to minimize discomfort and tissue damage.
• Do not mix with other medications unless instructed by your doctor.
• Report any pain, redness, or swelling at the injection site to your healthcare provider.
• Store the injection at room temperature, away from direct sunlight and moisture.
• Dispose of used needles and syringes safely in a designated sharps container.