Ofylin (400mg) 10 Tablets

Doxofylline is a xanthine derivative that primarily acts as a selective phosphodiesterase (PDE) inhibitor, with a higher affinity for PDE3 and PDE4 enzymes. These enzymes are responsible for breaking down cyclic adenosine monophosphate (cAMP) in various tissues, including the lungs and cardiovascular system. By inhibiting PDE3 and PDE4, doxofylline increases the intracellular concentration of cAMP, which leads to smooth muscle relaxation, particularly in the airways and blood vessels. This mechanism contributes to bronchodilation, making it easier to breathe, and also has a positive effect on cardiac function by improving contractility and reducing vascular resistance. Doxofylline's selectivity for specific PDE enzymes helps minimize some of the side effects associated with non-selective phosphodiesterase inhibitors, making it a useful therapeutic option for respiratory conditions and certain cardiovascular disorders.

Doxofylline 400mg

Bronchodilator, anti-inflammatory.

Tablet

The following are the uses of Doxofylline 400mg Tablet:

• Used for treating respiratory conditions like chronic obstructive pulmonary disease (COPD) and asthma.
• Used to relieve symptoms such as shortness of breath, coughing, and wheezing.
• Used to relax and open up constricted airways, making breathing easier.
• Used for reducing inflammation in the airways.
• Used for managing exercise-induced bronchoconstriction.
• Used as a long-term maintenance therapy to control and prevent asthma symptoms.
• Used as an alternative for patients who experience side effects with other similar medications.
• Used to improve overall lung function and quality of life for individuals with respiratory issues.

To be used as per doctor's prescription

In the case of an overdose of Doxofylline 400mg Tablets, the severity of symptoms may vary depending on the amount ingested. Common signs of overdose include nausea, vomiting, abdominal pain, and in more severe cases, seizures and cardiac arrhythmias. Promptly seek medical assistance if an overdose is suspected, as early intervention can help mitigate potential complications. The treatment for overdose involves supportive care and managing symptoms until the excess medication is eliminated from the body.

In the case of a missed dose of Doxofylline 400mg Tablet, it is important to take the medication as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. However, do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or asking someone to help you remember to take your medication on time. It is crucial to maintain a consistent dosing schedule for the medicine to be effective.

To take Doxofylline 400mg Tablet, swallow the tablet whole with a glass of water, preferably with or after a meal, as directed by your healthcare professional, typically once or twice a day, following the prescribed dosage and duration to ensure maximum effectiveness.

Following are the conditions when Doxofylline 400mg Tablet should not be used:

• Should not be used in individuals with a known allergy to Doxofylline or related compounds.
• Contraindicated in patients with severe heart failure or an unstable heart condition.
• Not suitable for individuals with a history of seizures or epilepsy.
• Should be avoided in patients with severe liver impairment or active liver disease.
• Not recommended for individuals with gastric or duodenal ulcers.
• Contraindicated during episodes of acute asthma attack, as it is a long-term control medication.
• Should not be used in patients with a history of allergic reactions to xanthines (related class of drugs).
• Not suitable for individuals with pheochromocytoma (a rare adrenal gland tumor).
• Should be used with caution and avoided if possible in patients with severe kidney disease.

The side effects of Doxofylline 400mg Tablet may include:

• Nausea and vomiting
• Headache
• Dizziness
• Palpitations or increased heart rate
• Restlessness
• Insomnia
• Skin rashes or itching

Following are the precautions and warnings for Doxofylline 400mg Tablet:

• Individuals with a known allergy to Doxofylline or related xanthine derivatives should not take this medication.
• Patients with severe heart conditions, such as recent myocardial infarction, should exercise caution and consult a doctor before use.
• Doxofylline may cause dizziness or drowsiness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Those with a history of seizures or epilepsy should use this medication with caution as it may lower the seizure threshold.
• Patients with liver or kidney disease should be monitored closely as dosage adjustments might be necessary.
• Elderly patients may be more susceptible to the side effects of Doxofylline, so careful monitoring is advised.
• This medication should be used with caution in patients with a history of gastric or duodenal ulcers, as it may exacerbate these conditions.
• Doxofylline should be discontinued if signs of allergic reactions or skin rashes occur, and medical attention should be sought immediately.

Following are the drug interactions for Doxofylline 400mg Tablet:

• Doxofylline may interact with xanthine oxidase inhibitors like allopurinol, potentially increasing the risk of side effects related to xanthine accumulation.
• Concomitant use with diuretics, especially loop diuretics, may result in excessive fluid loss and electrolyte imbalances.
• It can interact with certain cardiovascular medications like beta-blockers, leading to an increased risk of cardiovascular side effects.
• Doxofylline may enhance the effects of bronchodilators, and close monitoring is required when used together.
• Theophylline and other methylxanthines should be used cautiously with Doxofylline, as they may have additive effects and increase the risk of toxicity.
• Antacids may reduce the absorption of Doxofylline, so a gap should be maintained between their administration.
• Combining Doxofylline with certain antibiotics, such as macrolides or quinolones, may increase the risk of cardiovascular side effects.

Following are the food interactions for Doxofylline 400mg Tablet:

• Doxofylline may interact with caffeine-containing foods and beverages like coffee, tea, or energy drinks, potentially leading to increased side effects such as nervousness, restlessness, and insomnia.
• Fatty meals may slightly delay the absorption of Doxofylline, but this effect is generally not clinically significant.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of many medications, including Doxofylline, potentially leading to increased drug levels in the body.
• Alcohol intake should be limited as it may worsen respiratory symptoms and decrease the effectiveness of Doxofylline.
• Avoid high-sodium foods as Doxofylline may decrease sodium excretion, leading to increased sodium levels in the body.
• There is no known interaction with dairy products, but a balanced diet is recommended to maintain overall health.
• Always consult your healthcare provider for personalized advice regarding dietary considerations while taking Doxofylline.

Doxofylline 400mg Tablets should be stored in a cool and dry place, away from direct sunlight and moisture. It is recommended to keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain its integrity. Avoid exposing the medication to extreme temperatures, such as storing it in the refrigerator or leaving it in a hot car, as this can impact its effectiveness. Always check the expiration date before use, and do not use the tablets if they have passed their expiry. For proper disposal, do not throw the medication in the trash or flush it down the toilet; instead, consult a pharmacist or healthcare professional for safe and environmentally friendly disposal options. Keep the tablets out of children's reach to prevent accidental consumption.

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Following are the quick tips for Doxofylline 400mg Tablet:

• Take the tablet as directed by your doctor, typically twice daily.
• Consume the tablet with a full glass of water for easy swallowing.
• Maintain a consistent dosing schedule to ensure the medication's effectiveness.
• It can be taken with or without food, but avoid heavy meals to prevent potential side effects.
• Do not crush or chew the tablet; swallow it whole for optimal absorption.
• Inform your doctor about all medications you're taking to prevent potential drug interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.