Olbetam (250mg) 32 Capsules

Acipimox primarily acts as a lipid-regulating agent by inhibiting the production and secretion of very-low-density lipoproteins (VLDL) in the liver. It belongs to the class of drugs known as nicotinic acid derivatives or antihyperlipidemic agents. The mechanism of action involves the activation of prostaglandin D2 (PGD2) receptors, which leads to a decrease in hepatic VLDL synthesis and secretion. This reduction in VLDL levels subsequently lowers the levels of triglycerides and low-density lipoproteins (LDL) in the bloodstream. Acipimox also enhances the clearance of triglyceride-rich particles, further contributing to its lipid-lowering effects. By targeting these pathways, Acipimox helps to regulate lipid metabolism and is used to manage dyslipidemia and related conditions.

Acipimox 250mg

Lipid-regulating agent

Capsule

The following are the uses of Acipimox 250mg Capsule:

• Used for lowering high triglyceride levels in the blood.
• Used to reduce the risk of cardiovascular events in patients with high cholesterol and triglycerides.
• Used for managing metabolic syndrome by improving lipid levels.
• Used to support lifestyle changes for weight loss and improving lipid profile.
• Used to prevent the progression of atherosclerosis.
• Used to treat hyperlipidemia associated with diabetes or kidney disease.
• Used as an adjunct therapy for individuals with mixed dyslipidemia.

In the case of an overdose of Acipimox 250mg capsules, individuals may experience an array of symptoms. These can include gastrointestinal issues such as nausea, vomiting, and abdominal pain. Additionally, patients might encounter increased thirst and frequent urination. It is imperative to promptly seek medical assistance if an overdose is suspected, as healthcare professionals can provide appropriate treatment and support to mitigate potential health risks associated with excessive medication intake.

In the case of a missed dose of Acipimox 250mg Capsule, it is important to take the medication as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one. However, if you frequently miss doses, it's best to consult your healthcare provider for advice on how to adjust your medication schedule and ensure you're taking the medication effectively. It's crucial to maintain consistency in taking Acipimox as prescribed for optimal therapeutic benefits.

To take Acipimox 250mg Capsule, swallow the capsule whole with a full glass of water, preferably during or after a meal, once or twice a day as directed by your healthcare professional.

Here are the conditions and situations when Acipimox 250mg Capsule should not be taken:

• Not recommended for individuals with a known allergy to Acipimox or nicotinic acid.
• Contraindicated in patients with severe liver disease or active liver disorders.
• Should not be used in individuals with gout or high uric acid levels.
• Not suitable for patients with acute gout attacks.
• Avoid using in individuals with a history of gastrointestinal bleeding or ulcers.
• Not recommended for patients with uncontrolled diabetes.
• Should not be used in pregnant or breastfeeding women.
• Avoid in individuals with a history of heart disease or stroke.
• Not suitable for patients with low blood pressure.

The side effects of Acipimox 250mg Capsule may include:

• Skin rash or itching
• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Dizziness
• Headache
• Dry mouth
• Increased thirst

Following are the precautions and warnings for Acipimox 250mg Capsule:

• Not recommended for individuals with a known allergy to Acipimox or similar medications.
• Patients with a history of kidney or liver disease should use with caution and under medical supervision.
• It may cause dizziness or lightheadedness; avoid driving or operating heavy machinery until you know how it affects you.
• Alcohol consumption should be avoided or limited while taking this medication.
• Do not exceed the prescribed dosage, as it may lead to an increased risk of side effects.
• Pregnant and breastfeeding women should consult their doctor before taking this medication, as it may have potential risks.
• If you have diabetes, regular monitoring of blood glucose levels is necessary, as this medication can affect blood sugar control.
• Patients with gout should exercise caution as this medication may increase the risk of gout attacks.

Following are the drug interactions for Acipimox 250mg Capsule:

• Acipimox may interact with other hypoglycemic agents, including insulin and oral antidiabetic medications, enhancing their glucose-lowering effects and increasing the risk of hypoglycemia.
• When taken with statins (e.g., atorvastatin, simvastatin), Acipimox may increase the risk of muscle-related side effects, such as myopathy or rhabdomyolysis.
• Acipimox may reduce the effectiveness of oral contraceptives, so alternative or additional contraception methods should be considered.
• The use of Acipimox with certain antihypertensive medications, such as beta-blockers or calcium channel blockers, may result in an additive lowering of blood pressure, requiring monitoring for hypotension.
• The combination of Acipimox with anticoagulants (e.g., warfarin) may increase the risk of bleeding, as it may enhance the anticoagulant effects, requiring close monitoring of clotting parameters.
• Acipimox should be used cautiously with other fibrates (e.g., gemfibrozil, fenofibrate), as their combined use may increase the risk of liver toxicity or gallstones.
• Concurrent use of Acipimox with certain drugs that affect liver enzymes (e.g., rifampicin, barbiturates) may alter Acipimox's metabolism, potentially reducing its effectiveness.
• The combination of Acipimox and niacin or other lipid-lowering agents may increase the risk of muscle and liver-related side effects.
• Acipimox may enhance the effects of alcohol, leading to an increased risk of gastrointestinal side effects like nausea or abdominal discomfort.
• Care should be taken when using Acipimox with other medications that affect lipid metabolism, as the combination may increase the risk of liver damage or pancreatitis.

Following are the food interactions for Acipimox 250mg Capsule:

• Avoid consuming alcohol during treatment as it may increase the risk of liver-related side effects and alter the medication's effectiveness.
• Grapefruit and grapefruit juice should be consumed with caution as they can interfere with the metabolism of Acipimox, potentially leading to increased drug levels and side effects.
• High-fat meals may delay the absorption of Acipimox, causing a potential reduction in its effectiveness. It is advisable to take the medication on an empty stomach or with a light meal.
• Dairy products like milk, cheese, and yogurt may decrease the absorption of Acipimox. Consider separating these foods from medication intake by a few hours.
• Vitamin E supplements may reduce the absorption of Acipimox. It is recommended to maintain a gap of at least 4 hours between taking the medication and consuming Vitamin E supplements.
• Foods rich in Vitamin C, such as citrus fruits and broccoli, may interact with Acipimox and reduce its effectiveness. Consider moderating the intake of these foods during treatment.
• Avoid consuming herbal teas or supplements containing St. John's Wort as it may decrease the levels of Acipimox in the body, reducing its therapeutic effect.
• Avoid high-cholesterol foods like fatty meats, full-fat dairy, and fried foods as they may counteract the medication's lipid-lowering effects.

Acipimox 250mg Capsules should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. It is crucial to keep the capsules in their original packaging, tightly sealed, to maintain their integrity and prevent contamination. Avoid placing them in bathrooms or near heat-emitting appliances like heaters or ovens, as temperature fluctuations can impact the medicine's effectiveness. Dispose of any unused or expired capsules responsibly; do not flush them or pour them down the drain. Consult your pharmacist or healthcare provider for appropriate disposal methods, and always keep medications away from children to prevent accidental consumption.

Following are the quick tips for Acipimox 250mg Capsule:

• Take the capsule as directed by your doctor; do not change the dosage without medical advice.
• Swallow the capsule whole with a full glass of water; do not crush, chew, or break it.
• Take the capsule with meals to minimize stomach-related side effects.
• Maintain a low-fat diet as recommended by your doctor during the medication period.
• If you experience flushing, try avoiding alcohol and spicy foods.
• Avoid taking antacids within 2 hours of this medicine.
• Store the capsules in a cool, dry place, away from direct sunlight.