Aminophylline (10mg) 10 Tablets

Aminophylline, the active ingredient in Aminophylline Tablets, primarily exerts its therapeutic effects through two main mechanisms. Firstly, it acts as a bronchodilator by relaxing the smooth muscles in the airways. This action is mainly attributed to theophylline, a metabolite of aminophylline. Theophylline inhibits phosphodiesterase enzymes, leading to increased levels of cyclic adenosine monophosphate (cAMP) in smooth muscle cells. Elevated cAMP levels cause relaxation of the bronchial smooth muscles, resulting in bronchodilation and improved airflow to the lungs. Secondly, aminophylline has mild anti-inflammatory properties, which may contribute to its overall effectiveness in managing respiratory conditions.

Aminophylline

Bronchodilator.

Tablet

The following are the uses of Aminophylline Tablet:

• Used for opening up the airways and allowing better breathing, particularly in asthma and chronic obstructive pulmonary disease (COPD) patients.
• Used for treating bronchospasms, relaxing the airway muscles.
• Used for providing quick relief during sudden asthma attacks or periods of shortness of breath.
• Used for improving lung function by reducing inflammation and widening the airways.
• Used for managing exercise-induced asthma, enabling easier breathing during physical activity.
• Used for preventing asthma symptoms triggered by allergies or respiratory infections.
• Used for long-term management of asthma and COPD, often in combination with other medications.
• Used for its diuretic effect, aiding in the removal of excess fluid from the body in some cases.

In the case of an overdose of Aminophylline Tablets, prompt medical intervention is necessary. Symptoms may include nausea, vomiting, rapid heartbeat, and seizures. It is important to seek emergency medical care and inform healthcare professionals about the overdose. They will closely monitor vital signs and may administer specific treatments to manage the overdose, such as activated charcoal or intravenous fluids. Quick action can help mitigate the potential harm caused by an overdose.

In the case of a missed dose of Aminophylline Tablet, it is important to take action promptly. If you remember within a few hours of the missed dose, take the missed dose right away. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. Consult your healthcare provider if you have any concerns or questions regarding missed doses, especially if you experience any symptoms or side effects.

To take the Aminophylline Tablet, swallow the tablet whole with a full glass of water, usually every 6 to 8 hours or as directed by your healthcare professional. It is important to follow the prescribed dosage and not crush, chew, or break the tablet to ensure proper absorption and effectiveness.

Following are the conditions when Aminophylline Tablet should not be used:

• Should not be used in patients with a known allergy to Aminophylline or other xanthine derivatives like Theophylline or Caffeine.
• Contraindicated in individuals with a history of seizures or epilepsy.
• Not recommended for patients with severe heart conditions, such as recent heart attack or unstable angina.
• Should not be used in people with severe high blood pressure (hypertension).
• Contraindicated in patients with stomach ulcers or gastrointestinal bleeding.
• Not suitable for individuals with liver or kidney disease.
• Should be avoided in patients with severe anxiety or panic disorders.
• Contraindicated during the last stages of pregnancy, especially close to delivery.

The side effects of Aminophylline Tablet may include:

• Nausea and vomiting
• Stomach pain or discomfort
• Headache
• Rapid or irregular heartbeat (palpitations)
• Nervousness or restlessness
• Insomnia
• Tremors or shaking
• Dizziness or lightheadedness

Following are the precautions and warnings for Aminophylline Tablets:

• This medication should be used with caution in patients with a history of seizures, as it may lower the seizure threshold.
• Patients with cardiovascular conditions such as arrhythmias or coronary artery disease should be closely monitored, as Aminophylline can affect heart rate and rhythm.
• Regular monitoring of serum theophylline levels is necessary to ensure therapeutic levels and prevent toxicity.
• Elderly patients may be more susceptible to side effects and should be monitored closely for adverse reactions.
• Aminophylline should be used with caution in individuals with liver or kidney disease, as these conditions can affect drug metabolism and clearance.
• Patients should be advised to avoid excessive caffeine consumption, as it may enhance the stimulant effects of the medication.
• Smoking can alter the metabolism of Aminophylline, and patients should be encouraged to quit smoking for optimal therapeutic outcomes.

Following are the drug interactions for Aminophylline Tablet:

• It may interact with other xanthine derivatives, increasing the risk of side effects such as nausea, vomiting, and seizures.
• Theophylline levels can be altered by drugs like cimetidine, ciprofloxacin, or macrolide antibiotics, potentially leading to toxicity.
• Aminophylline can enhance the effects of certain heart medications like digoxin, requiring close monitoring.
• Anticoagulants like warfarin may have their effects potentiated, requiring careful monitoring of coagulation parameters.
• Drugs that induce or inhibit liver enzymes, such as rifampicin or ketoconazole, can affect the metabolism of aminophylline.
• Caution is advised when combining with other bronchodilators, as it may lead to excessive stimulation of the respiratory system.
• Phenytoin and phenobarbital may decrease the effectiveness of aminophylline by increasing its clearance.

Following are the food interactions for Aminophylline Tablet:

• Avoid consuming large amounts of caffeine-containing products like coffee, tea, or energy drinks, as Aminophylline already contains caffeine, and excess caffeine may lead to restlessness, rapid heartbeat, and insomnia.
• Grapefruit and grapefruit juice should be consumed with caution as they can interfere with the breakdown of Aminophylline, leading to increased levels in the blood and potential side effects.
• Limit the intake of high-fat meals as they may delay the absorption of Aminophylline, affecting its effectiveness.
• Alcohol may enhance the side effects of Aminophylline, causing increased heart rate and nervousness, so it's best to avoid or limit alcohol consumption.
• Avoid chocolate and cocoa-rich foods as they contain a compound that can inhibit the breakdown of theophylline, one of the components in Aminophylline.
• Consuming a balanced diet rich in fruits, vegetables, and whole grains can help maintain the overall effectiveness of the medication.
• Always follow the advice of your healthcare provider regarding dietary restrictions or recommendations while taking Aminophylline.
• Stay well-hydrated, as proper hydration can aid in the efficient functioning of the medication in the body.

Aminophylline Tablets should be stored in a cool, dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Protect the tablets from light and moisture by keeping them in their original container, tightly sealed. It is crucial not to expose the medication to excessive heat or cold, so avoid storing it in the bathroom or inside vehicles during hot weather. Always check the expiration date, and never use the tablets if they are expired. For disposal, do not throw them into the trash or flush them down the toilet; instead, follow local guidelines or consult a pharmacist for safe disposal methods to prevent harm to the environment. Keep the tablets away from children and pets to prevent accidental ingestion.

Following are the quick tips for Aminophylline Tablet:

• Consult your doctor before taking this medication, especially if you have heart problems, seizures, or hyperthyroidism.
• Take the tablet as directed by your healthcare provider, typically every 6-8 hours.
• Ensure you drink plenty of fluids while taking this medication.
• Avoid alcohol consumption as it may increase the risk of side effects.
• If you experience nausea, vomiting, or insomnia, inform your doctor promptly.
• Do not stop taking the medication suddenly without medical advice.
• Store the tablets in a cool, dry place, away from direct sunlight.