Olesta-AM (10/40mg) 20 Tablets

Amlodipine 10mg and Olmesartan 40mg, when combined in a tablet, have a synergistic effect on lowering blood pressure. Amlodipine, a calcium channel blocker, inhibits the influx of calcium ions into smooth muscle cells, leading to vasodilation of blood vessels. This relaxation of vascular smooth muscles, particularly in the peripheral arterial system, reduces peripheral vascular resistance and lowers blood pressure. Olmesartan, an angiotensin II receptor blocker (ARB), acts by blocking the binding of angiotensin II to its receptors. Angiotensin II is a potent vasoconstrictor, and by blocking its effects, Olmesartan prevents the constriction of blood vessels and reduces blood pressure. Together, the combination of Amlodipine and Olmesartan provides enhanced blood pressure control by targeting different mechanisms involved in the regulation of vascular tone and blood volume.

Amlodipine 10mg, Olmesartan 40mg

Calcium channel blocker, Angiotensin II receptor blocker.

Tablet

The following are the uses of Amlodipine 10mg, Olmesartan 40mg Tablet:

• Used for treating high blood pressure (hypertension)
• Used to relax and widen blood vessels, improving blood flow
• Used to reduce the workload on the heart
• Used for managing angina (chest pain) associated with reduced blood flow to the heart
• Used for preventing symptoms of coronary artery disease
• Used for improving exercise tolerance in individuals with cardiovascular conditions
• Used for controlling blood pressure to reduce the risk of stroke, heart attack, and kidney problems
• Used as a long-term treatment to maintain cardiovascular health

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Take 1 tablet per day.
• Dosage should be adjusted based on the severity of the disease and response to treatment.

In the case of an overdose of Amlodipine 10mg and Olmesartan 40mg tablets, individuals may experience symptoms such as severe hypotension, dizziness, and bradycardia. It is crucial to seek medical assistance promptly as the consequences can be life-threatening. The severity of the reaction depends on the individual's health and the amount ingested. If you suspect an overdose, contact a healthcare professional or poison control center immediately for guidance and support. Timely intervention is vital to prevent potential complications.

In the case of a missed dose of Amlodipine 10mg, it is generally recommended to take the missed dose as soon as you remember, but if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. For Olmesartan 40mg Tablet, if you miss a dose, take it as soon as you remember, but if it is within 12 hours of your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one.

To take Amlodipine 10mg and Olmesartan 40mg tablets, swallow one tablet daily, preferably at the same time each day, with or without food, as directed by your healthcare provider.

Following are the conditions/situations when Amlodipine 10mg and Olmesartan 40mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to amlodipine, olmesartan, or any other angiotensin II receptor blockers (ARBs).
• Not suitable for individuals with severe liver disease or liver impairment.
• Contraindicated in patients with a condition called aortic stenosis, a narrowing of the aortic valve in the heart.
• Should not be used in patients with a condition called obstructive jaundice, where bile flow is blocked.
• Not recommended for individuals with a history of angioedema (swelling of the face, lips, tongue, or throat) with previous use of similar medications.
• Should be avoided in pregnant or breastfeeding women, unless the potential benefits outweigh the risks.
• Not suitable for individuals with severe hypotension (very low blood pressure).
• Should not be used in patients with a condition called renal artery stenosis, a narrowing of the arteries that supply blood to the kidneys.
• Contraindicated in patients with a condition called hyperkalemia, where there is a high level of potassium in the blood.

The side effects of Amlodipine 10mg, Olmesartan 40mg Tablet may include:

• Dizziness or lightheadedness
• Swelling of the ankles and feet (peripheral edema)
• Fatigue or weakness
• Headache
• Nausea and vomiting
• Skin rash or itching
• Increased heart rate (tachycardia)
• Muscle cramps

Following are the precautions and warnings for Amlodipine 10mg, Olmesartan 40mg Tablet:

• Individuals with known allergies to Amlodipine, Olmesartan or related medications should avoid this medication.
• Patients with a history of liver or kidney disease should use with caution and under medical supervision as dosage adjustments might be necessary.
• Elderly patients may be more sensitive to the effects of this medication, particularly dizziness and lightheadedness.
• Caution is advised when taking this medication with other blood pressure medications, as it may cause an excessive drop in blood pressure.
• It may cause swelling in the ankles, feet, or legs, so regular monitoring is recommended.
• Patients with a history of heart disease or aortic stenosis should use this medication with caution and under medical supervision.
• Not recommended for use during pregnancy or breastfeeding without medical advice.
• Diabetic patients should monitor blood sugar levels regularly as this medication may affect blood sugar control.

Following are the drug interactions for Amlodipine 10mg, Olmesartan 40mg Tablet:

• Amlodipine may enhance the blood pressure-lowering effect of other antihypertensive drugs, leading to hypotension.
• Concomitant use with CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) can increase amlodipine levels, potentially requiring dose adjustments.
• Olmesartan may have additive effects with other drugs that affect the renin-angiotensin system, such as ACE inhibitors or aliskiren, increasing the risk of hypotension and renal impairment.
• NSAIDs (e.g., ibuprofen) may diminish the antihypertensive effect of olmesartan and amlodipine.
• Lithium levels may be increased when used with amlodipine, requiring close monitoring.
• Grapefruit juice can increase the plasma concentrations of amlodipine, potentially leading to increased side effects.
• Caution is advised when combining with other drugs that cause edema, as amlodipine may exacerbate this effect.
• Amlodipine may have a minor interaction with statins, potentially increasing the risk of muscle-related side effects.

Following are the food interactions for Amlodipine 10mg, Olmesartan 40mg Tablet:

• Grapefruit and grapefruit juice should be consumed cautiously as they can increase the blood levels of amlodipine, potentially leading to increased side effects such as dizziness and low blood pressure.
• Limit the consumption of alcohol as it can further lower blood pressure and may increase the risk of side effects, especially dizziness and lightheadedness.
• Avoid excessive salt (sodium) intake, as this medication is used to treat high blood pressure, and high salt intake can counteract its effects.
• Avoid potassium-rich foods like bananas, oranges, and green leafy vegetables if you are also taking a potassium-sparing diuretic, as it may lead to high potassium levels.
• Avoid or limit high-fat meals as they can affect the absorption of olmesartan, reducing its effectiveness.
• Avoid natural licorice, as it may decrease the effectiveness of olmesartan and lead to increased blood pressure.
• Do not use salt substitutes without medical advice, as these often contain potassium, and their use may lead to high potassium levels in the blood.
• There is no significant impact on the effectiveness of this medication from most normal dietary variations.

Amlodipine 10mg, Olmesartan 40mg tablets should be stored in a cool, dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Keep the tablets in their original container, tightly sealed, to protect them from moisture and light. It's crucial to keep the medication away from children and pets. Do not store the tablets in the bathroom medicine cabinet as humidity can affect their quality. When disposing of unused or expired tablets, do not throw them into the trash or flush them down the toilet. Instead, follow local guidelines or consult your pharmacist for safe disposal methods to protect the environment. Proper disposal ensures that the medication does not pose a risk to others or contaminate water sources.

Following are the quick tips for Amlodipine 10mg and Olmesartan 40mg Tablet:

• Take the medication as directed by your doctor, usually once daily.
• Swallow the tablet whole with a full glass of water, preferably at the same time each day.
• Do not crush, chew, or break the tablet, as it may affect its effectiveness.
• It can be taken with or without food, but taking it with food may help prevent stomach upset.
• Avoid grapefruit and grapefruit juice as they can interact with the medication.
• Inform your doctor about all the medications you are taking to prevent potential drug interactions.
• Regularly monitor your blood pressure and consult your doctor for any concerns.

Both Amlodipine and Olmesartan Medoxomil are medications prescribed to help treat high blood pressure, a condition also known as hypertension. These medications are effective in reducing blood pressure, but to ensure they are safely doing so, certain relevant lab tests may be required. Firstly, it is vital to regularly monitor your blood pressure to ensure the medications are working as intended and to adjust any dosage if needed. Furthermore, as both medicines can cause the levels of potassium in the blood to increase, blood tests to monitor potassium levels may be recommended. Maintaining a normal level of potassium is crucial to prevent any further complications. Diabetic patients may be required to have fasting blood sugar levels tested on a monthly basis, and for those who have undergone the glycosylated hemoglobin test, adjustments can be made to diabetes control every three months. However, it is worth noting that the need for these specific tests will depend on individual circumstances and the advice of your doctor. Overall, it is important to communicate with your doctor and adhere to their guidance on lab tests and monitoring to ensure your treatment is safe and effective in the long term, and any concerns in relation to blood tests or side effects can be adequately addressed by your doctor.