Omsana-AM (5/20mg) 20 Tablets

Amlodipine 5mg and Olmesartan 20mg work synergistically in the tablet to lower blood pressure. Amlodipine belongs to the calcium channel blocker class of medications. It inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells, leading to relaxation and dilation of blood vessels. This action reduces peripheral vascular resistance and decreases blood pressure. Olmesartan, on the other hand, is an angiotensin II receptor blocker (ARB). It selectively blocks the binding of angiotensin II to AT1 receptors in tissues, such as vascular smooth muscle and the adrenal glands. By blocking the effects of angiotensin II, olmesartan causes vasodilation, reduces vascular resistance, and decreases blood pressure. Together, the combined effect of amlodipine and olmesartan in this tablet helps to effectively manage hypertension by targeting different mechanisms involved in blood pressure regulation.

Amlodipine 5mg, Olmesartan 20mg

Calcium channel blocker, Angiotensin II receptor blocker.

Tablet

The following are the uses of Amlodipine 5mg, Olmesartan 20mg Tablet:

• Used for managing high blood pressure (hypertension)
• Used for relaxing and widening blood vessels to improve blood flow
• Used for treating angina, relieving chest pain and reducing the frequency of attacks
• Used for improving exercise tolerance in patients with cardiovascular conditions
• Used for reducing the risk of heart attack, stroke, and other cardiovascular complications
• Used for managing hypertension in patients who haven't responded to other medications
• Used for controlling blood pressure to prevent related health issues

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Take 1 tablet per day.
• Dosage should be adjusted based on the severity of the disease and response to treatment.

In the case of an overdose of Amlodipine 5mg and Olmesartan 20mg tablets, the severity of symptoms can vary. Common signs include excessive dizziness, a significant drop in blood pressure, and a rapid or irregular heartbeat. Promptly seek medical assistance if an overdose is suspected. Treatment may involve supportive care, such as monitoring vital signs and managing symptoms, and in severe cases, more specialized interventions might be necessary to ensure the patient's well-being.

In the case of a missed dose of Amlodipine 5mg, take the missed dose as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. For Olmesartan 20mg, if you miss a dose, take it as soon as you remember, but if it's close to the time of your next dose, skip the missed dose and resume your regular dosing pattern. It's important not to double the dose to make up for a missed one, as this could lead to an excessive medication effect. Consult your healthcare provider if you frequently miss doses to determine the best course of action.

To take the Amlodipine 5mg and Olmesartan 20mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare provider.

Following are the conditions when Amlodipine 5mg, Olmesartan 20mg Tablet should not be taken:

• Avoid if you are allergic to any of the components in the tablet, especially Amlodipine or Olmesartan.
• Do not take this medication if you have a history of angioedema (swelling of the face, lips, tongue, or throat) with previous use of similar medications.
• Not suitable for individuals with severe liver disease or impaired liver function.
• Should not be used in patients with severe hypotension (very low blood pressure).
• Contraindicated in patients with aortic stenosis (narrowing of the aortic valve in the heart).

The side effects of Amlodipine 5mg, Olmesartan 20mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Headache
• Swelling of ankles and feet (peripheral edema)
• Nausea and stomach pain
• Skin rash or itching
• Rapid or irregular heartbeat
• Muscle pain or cramps

Following are the precautions and warnings:

• Amlodipine/Olmesartan tablets should not be taken by individuals who are allergic to any of its components, including amlodipine or olmesartan.
• This medication is not recommended for individuals with severe liver disease or those who are pregnant or breastfeeding, unless advised by a healthcare professional.
• Patients with a history of heart, kidney, or liver problems should exercise caution and inform their doctor, as dosage adjustments may be necessary.
• Amlodipine may cause dizziness or lightheadedness, especially in the initial stages of treatment. Avoid activities requiring alertness until you know how this medication affects you.
• Olmesartan can lead to a condition called intestinal angioedema, which causes abdominal pain and diarrhea; seek medical attention if these symptoms occur.
• If you have a history of heart failure, this medication may worsen your symptoms. Regular monitoring is essential.
• Some patients may experience a worsening of chest pain (angina) when starting amlodipine/olmesartan therapy, especially those with severe coronary artery disease. Medical advice should be sought immediately if this occurs.
• Elderly patients may be more sensitive to the effects of this medication, particularly dizziness and lightheadedness.

Following are the drug interactions for Amlodipine 5mg, Olmesartan 20mg Tablet:

• Amlodipine may increase the blood pressure-lowering effect of other antihypertensive medications, such as beta-blockers or ACE inhibitors, leading to excessive hypotension.
• Olmesartan's blood pressure-lowering effect can be reduced by NSAIDs (e.g., ibuprofen), potentially decreasing its effectiveness.
• The risk of angioedema may increase with ACE inhibitors and Amlodipine.
• Grapefruit juice can increase the blood levels of Amlodipine, potentially leading to increased side effects.
• Rifampicin, a strong CYP3A4 inducer, may decrease Amlodipine's effectiveness by increasing its metabolism.
• The effectiveness of Olmesartan may be reduced by certain diuretics, requiring close monitoring.
• Combining Amlodipine with other calcium channel blockers may cause excessive hypotension and heart rhythm abnormalities.
• Antifungal medications like ketoconazole can increase Amlodipine's blood levels, potentially requiring dose adjustments.

Following are the food interactions for Amlodipine 5mg, Olmesartan 20mg Tablet:

• Grapefruit and grapefruit juice should be avoided as they may interfere with the metabolism of Amlodipine, leading to increased drug levels in the body and potentially causing side effects.
• Limit the consumption of foods high in potassium like bananas, oranges, and spinach, as Olmesartan can increase potassium levels.
• Avoid excessive alcohol intake, as it may enhance the blood pressure-lowering effect of Amlodipine and Olmesartan, leading to dizziness and lightheadedness.
• Salt substitutes or potassium-rich foods should be used cautiously, as Olmesartan may increase potassium levels, causing issues in patients with kidney problems.
• A high-fat meal can increase the absorption of Amlodipine, potentially leading to higher blood levels of the drug.
• Licorice should be avoided as it may decrease the effectiveness of Olmesartan by reducing blood pressure-lowering effects.
• Avoid or limit caffeine intake, as it may counteract the blood pressure-lowering effect of Amlodipine and Olmesartan.
• Consult your doctor or pharmacist if you have any concerns about specific food interactions.

Amlodipine 5mg, Olmesartan 20mg tablets should be stored in a cool, dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Keep the tablets in their original container, tightly sealed, to protect them from moisture and light. It is crucial to maintain a consistent storage environment, avoiding exposure to excessive heat or cold. When disposing of unused or expired tablets, do not throw them into the trash or flush them down the toilet. Instead, follow local guidelines for medication disposal or consult your pharmacist for advice on safe disposal methods. This ensures that the medication is disposed of responsibly, minimizing potential environmental impact. Keep the medication out of the reach of children and pets to prevent accidental ingestion.

Following are the quick tips for Amlodipine 5mg and Olmesartan 20mg Tablet:

• Take the tablet as directed by your doctor, typically once daily.
• Consume the tablet whole with a full glass of water, preferably at the same time each day.
• Amlodipine can be taken with or without food, but Olmesartan should be taken with food to enhance absorption.
• Avoid grapefruit juice as it may affect the medication's effectiveness.
• If you miss a dose, take it as soon as you remember, unless it's close to your next dose.
• Do not double the dose to make up for a missed one.
• Store the tablets at room temperature, away from moisture and light.

Amlodipine and Olmesartan Medoxomil are two medications that are often prescribed to treat high blood pressure, a condition also known as hypertension. While these medications can be effective in controlling blood pressure, it is important to note that they can have significant effects on the body and therefore require routine monitoring. Routine monitoring of these medications involves several lab tests. Firstly, it is important to routinely check your blood pressure, as these medications only work if they are at adequate levels in your body, and the frequency of checks may vary from person to person. Secondly, given the potential impact on kidney function, routine kidney function tests should be conducted, including evaluations of serum creatinine, blood urea nitrogen, and electrolytes, to ensure any imbalances or disruptions are addressed. Thirdly, since these medications is metabolized in the liver, routine liver function tests should be undertaken to check for any signs of harm. This often includes testing liver enzymes and albumin. Lastly, given the widespread impacts of high blood pressure and these medications, a complete blood count (CBC) is often undertaken to assess overall health and uncover any potential issues, such as anemia or infections. Overall, while amlodipine and olmesartan medoxomil can be effective medications for high blood pressure, it is essential to closely monitor their effects on the body to ensure optimal health. Your doctor will help to determine the frequency of these tests, and you should discuss any concerns or experiences of adverse effects with them, as they may alter your dosage or switch you to a different treatment plan.