Omsana DIU (20/25mg) 10 Tablets

Hydrochlorothiazide and Olmesartan Medoxomil both work synergistically in the tablet to lower blood pressure. Hydrochlorothiazide is a diuretic that increases urinary excretion of sodium and chloride, leading to increased water loss and reduced blood volume, which helps to lower blood pressure. It inhibits the reabsorption of sodium and chloride ions in the distal convoluted tubule of the kidney, promoting the loss of water and electrolytes. Olmesartan Medoxomil, on the other hand, is an angiotensin II receptor blocker (ARB). It selectively blocks the binding of angiotensin II to its receptors, primarily in the vascular smooth muscle. Angiotensin II is a potent vasoconstrictor, so by blocking its effects, Olmesartan Medoxomil causes vasodilation, reduces peripheral resistance, and decreases blood pressure. This combination of mechanisms helps to effectively control hypertension by targeting both fluid balance and vascular resistance.

Hydrochlorothiazide 25mg, Olmesartan Medoxomil 20mg

Angiotensin II Receptor Blocker, Diuretic.

Tablet

The following are the uses of Hydrochlorothiazide 25mg, Olmesartan Medoxomil 20mg Tablet:

• Used for treating high blood pressure (hypertension)
• Used to lower blood pressure and reduce the risk of stroke or heart attack
• Used for managing fluid retention (edema) caused by various conditions
• Used to promote fluid elimination and reduce excess water in the body
• Used for improving blood flow and reducing strain on the heart
• Used to control blood pressure in patients with kidney disease
• Used to support overall cardiovascular health

In the case of an overdose of Hydrochlorothiazide 25mg and Olmesartan Medoxomil 20mg Tablets, individuals may experience symptoms such as dizziness, hypotension, and electrolyte imbalances. The severity of these symptoms can vary depending on the amount ingested. It is important to seek medical advice promptly and provide information about the medication and dosage to healthcare professionals. They can offer guidance and treatment options to manage the overdose effectively and minimize potential complications.

In the case of a missed dose of Hydrochlorothiazide 25mg, it is generally recommended to take the missed dose as soon as you remember, unless it's almost time for your next scheduled dose. If it's close to the next dose, skip the missed one and resume your regular dosing schedule. For Olmesartan Medoxomil 20mg, if a dose is missed, take it as soon as possible on the same day. If you don't remember until the next day, skip the missed dose and continue with your regular dosing schedule. It's important to try to take your medications at the same time each day to maintain consistent blood levels.

To take the Hydrochlorothiazide 25mg, Olmesartan Medoxomil 20mg Tablet, swallow the tablet whole with a full glass of water, preferably in the morning or as directed by your healthcare provider, without crushing or chewing it.

Here are the conditions or situations when Hydrochlorothiazide 25mg, Olmesartan Medoxomil 20mg Tablet should not be used:

• Should not be used in patients with a known allergy to either Hydrochlorothiazide or Olmesartan Medoxomil, or any other sulfonamide-derived drugs.
• Contraindicated in individuals with severe renal impairment or patients with a history of anuria (absence of urine production).
• Not recommended for patients with severe hepatic impairment or biliary obstruction.
• Should not be used during pregnancy or by breastfeeding mothers.
• Contraindicated in patients with a history of angioedema (swelling of deep layers of the skin) induced by previous treatment with angiotensin II receptor antagonists.
• Not suitable for individuals with hyperkalemia (high potassium levels in the blood).
• Should be avoided in patients with severe dehydration or those who have recently experienced a significant loss of fluids.

The side effects of Hydrochlorothiazide 25mg, Olmesartan Medoxomil 20mg Tablet may include:

• Dizziness
• Fatigue or weakness
• Nausea and vomiting
• Diarrhea
• Muscle cramps
• Increased sensitivity to sunlight
• Skin rash or itching
• Low blood pressure (hypotension)

Following are the precautions and warnings for Hydrochlorothiazide 25mg, Olmesartan Medoxomil 20mg Tablet:

• This medication should not be taken by individuals with a known allergy to hydrochlorothiazide, olmesartan, or any other angiotensin II receptor blocker (ARB).
• Patients with a history of kidney or liver disease should use this medication with caution, as it may require dosage adjustments or close monitoring.
• It may cause an increased sensitivity to sunlight; patients should avoid prolonged sun exposure and use protective measures.
• Patients with diabetes should monitor their blood sugar levels regularly, as this medication can affect glucose control.
• Elderly patients may be more susceptible to side effects such as dizziness and lightheadedness, and should exercise caution to avoid falls.
• Pregnant or breastfeeding women should consult their doctor before taking this medication, as it may have potential risks for the fetus or infant.
• Patients should inform their healthcare provider about all other medications they are taking to avoid potential drug interactions.

Following are the drug interactions for Hydrochlorothiazide 25mg, Olmesartan Medoxomil 20mg Tablet:

• Lithium levels may be increased with thiazide diuretics like Hydrochlorothiazide, leading to lithium toxicity.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the blood pressure-lowering effect of Olmesartan and can increase the risk of kidney function impairment.
• The antihypertensive effect of Olmesartan can be reduced by certain corticosteroids, resulting in decreased blood pressure control.
• Hydrochlorothiazide may increase blood calcium levels, which can be further elevated when combined with calcium supplements or calcium-containing antacids.
• The effectiveness of Hydrochlorothiazide may be reduced by cholestyramine, as it can decrease its absorption.
• When combined with diabetes medications, Hydrochlorothiazide may enhance the blood glucose-lowering effect, potentially causing hypoglycemia.
• Olmesartan's blood pressure-lowering effect may be reduced by certain pain medications, such as acetaminophen and NSAIDs.

Following are the food interactions for Hydrochlorothiazide 25mg and Olmesartan Medoxomil 20mg Tablet:

• Avoid excessive salt intake, as Hydrochlorothiazide is a diuretic and can increase urination, leading to potential electrolyte imbalances. Reduce high-sodium foods like processed snacks, canned soups, and fast food.
• Potassium-rich foods like bananas, oranges, and spinach are beneficial, as Hydrochlorothiazide may deplete potassium levels.
• Avoid alcohol, as it can increase the risk of dizziness and lightheadedness, especially with Olmesartan, which may also lower blood pressure.
• Grapefruit and grapefruit juice should be limited or avoided, as they can affect the metabolism of Olmesartan, potentially increasing its levels in the blood.
• Maintain a balanced diet low in saturated fats and cholesterol, as Olmesartan is often prescribed for hypertension and cardiovascular health.
• Ensure adequate hydration, as Hydrochlorothiazide can cause dehydration and electrolyte imbalances.
• Avoid licorice or licorice-containing products, as they may decrease the effectiveness of Olmesartan by reducing potassium levels.

Hydrochlorothiazide 25mg, Olmesartan Medoxomil 20mg tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. It is crucial to keep the tablets in their original packaging, tightly sealed, to maintain their integrity. Avoid storing them in bathrooms or areas exposed to heat, as temperature fluctuations can impact their effectiveness. Regularly check the expiration date, and dispose of expired or unused tablets responsibly, refraining from flushing them or pouring them down the drain. Consult your pharmacist for guidance on safe disposal practices. Keep the medication securely stored away from children to prevent accidental consumption.

Following are the quick tips for Hydrochlorothiazide 25mg and Olmesartan Medoxomil 20mg Tablet:

• Take the medication as directed by your doctor; do not adjust the dosage without medical advice.
• Take the tablet with a full glass of water, preferably in the morning.
• It can be taken with or without food, but taking it with food may prevent stomach upset.
• Stand or sit upright for at least 30 minutes after taking the tablet to prevent irritation in the throat.
• Avoid salt substitutes and potassium supplements unless advised by your doctor.
• Regularly monitor your blood pressure and kidney function while on this medication.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.