Onato (10mg) 20 Tablets

Amlodipine 10mg tablets primarily work by blocking calcium channels in the cardiovascular system, specifically targeting L-type calcium channels in vascular smooth muscle cells. By inhibiting these channels, amlodipine prevents calcium ions from entering the cells, leading to relaxation of the smooth muscles in blood vessels. This mechanism results in vasodilation, which reduces peripheral vascular resistance and lowers blood pressure. Amlodipine's selective action on peripheral resistance vessels, without affecting the heart's contractility, contributes to its effectiveness in treating hypertension and angina by improving blood flow and reducing the workload on the heart.

Amlodipine 10mg

Calcium channel blocker.

Tablet

The following are the uses of Amlodipine 10mg Tablet:

• Used for treating high blood pressure (hypertension), helping to control and manage the condition.
• Used for angina, relieving chest pain and discomfort associated with restricted blood flow to the heart.
• Used to prevent episodes of chest pain in individuals with a history of angina.
• Used to manage and reduce the frequency of Raynaud's phenomenon attacks, which cause finger and toe discomfort due to poor blood circulation.
• Used for improving blood circulation, particularly in conditions where blood vessels may be narrowed or constricted.
• Used to treat and manage coronary artery disease, aiding in blood flow to the heart muscle.
• Used to lower the risk of heart attack or stroke in individuals with specific cardiovascular conditions.
• Used for long-term management of vascular conditions, ensuring consistent blood flow and reducing the strain on the heart.

To be taken as per doctor's prescription

In the case of an overdose of Amlodipine 10mg Tablets, it is important to recognize the potential severity of this situation. Symptoms may include lightheadedness, dizziness, and an irregular heartbeat. If you suspect an overdose, seek medical advice promptly. Treatment may involve monitoring vital signs, and in severe cases, hospitalization and supportive care might be necessary. Prompt action can help manage the risks associated with Amlodipine overdose effectively.

In the case of a missed dose of Amlodipine 10mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you frequently miss doses, it is recommended to set reminders or use a pill organizer to help you stay on track. Consult your healthcare provider if you have any concerns or if you miss multiple doses in a row, as they can provide guidance on how to manage your medication effectively.

To take Amlodipine 10mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare provider.

Following are the conditions/situations when Amlodipine 10mg Tablet should not be used:

• Should not be used in individuals with a known allergy to Amlodipine or calcium channel blockers.
• Not recommended for patients with severe hypotension (very low blood pressure).
• Contraindicated in patients with cardiogenic shock (shock caused by heart problems).
• Should not be used in individuals with acute myocardial infarction (heart attack) or unstable angina.
• Avoid using if you have aortic stenosis (narrowing of the aortic valve in the heart).
• Not suitable for patients with severe aortic valve disease.
• Should not be used in individuals with heart failure or reduced heart function.
• Contraindicated during pregnancy and breastfeeding.
• Not recommended for patients with liver disease or impaired liver function.
• Avoid using if you have severe kidney disease or kidney failure.

The side effects of Amlodipine 10mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Headache
• Swelling of the ankles and feet (peripheral edema)
• Flushing (feeling of warmth or redness in the face)
• Palpitations or increased heart rate
• Gastrointestinal discomfort (nausea, abdominal pain)
• Muscle cramps

Following are the precautions and warnings:

• Amlodipine 10mg tablets should not be taken by individuals who are allergic to amlodipine or any other ingredients in the medication.
• Patients with liver or kidney disease must exercise caution as dosage adjustments might be necessary.
• This medication can cause dizziness and lightheadedness, so activities requiring alertness, such as driving or operating machinery, should be avoided until the full effects are known.
• Amlodipine may not be suitable for individuals with certain heart conditions, such as aortic stenosis or unstable angina.
• It is important to monitor blood pressure regularly while taking this medication, especially during the initial phase of treatment.
• Patients with diabetes should be aware that Amlodipine may affect blood sugar levels.
• Pregnant and breastfeeding women should consult their doctor before taking this medication, as it may have potential risks for the fetus or infant.
• Always inform your healthcare provider about all the medications you are currently taking to avoid potential drug interactions.

Following are the drug interactions for Amlodipine 10mg Tablet:

• Grapefruit juice can increase amlodipine levels, leading to increased blood pressure lowering effects. Avoid consuming large amounts of grapefruit juice.
• Concomitant use with CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) may increase amlodipine concentrations, requiring dose adjustments.
• Amlodipine can enhance the hypotensive effects of other antihypertensive drugs, leading to excessive blood pressure drop.
• Taking amlodipine with certain calcium channel blockers (e.g., diltiazem, verapamil) can cause significant hypotension and bradycardia.
• NSAIDs (e.g., ibuprofen, naproxen) may reduce the antihypertensive effects of amlodipine.
• Rifampicin, a CYP3A4 inducer, can decrease amlodipine levels, potentially reducing its effectiveness.
• The combination of amlodipine with beta-blockers may lead to additive effects on heart rate and blood pressure, requiring close monitoring.
• Simvastatin levels may be increased when used with amlodipine, raising the risk of muscle-related side effects.

Following are the food interactions for Amlodipine 10mg Tablet:

• Grapefruit and grapefruit juice should be consumed with caution as they may increase the blood levels of Amlodipine, potentially causing an excessive drop in blood pressure.
• Alcohol may cause a mild decrease in blood pressure, which can be additive to the effect of Amlodipine, leading to dizziness or lightheadedness.
• Avoid excessive salt or sodium-rich foods as they can counteract the blood pressure-lowering effect of Amlodipine.
• High-fat meals may slightly delay the absorption of Amlodipine, but this is generally not clinically significant.
• Potassium-rich foods like bananas, oranges, and spinach should be consumed in moderation as Amlodipine can sometimes cause an increase in potassium levels.
• Licorice contains a compound that can inhibit an enzyme necessary for Amlodipine's metabolism, potentially increasing its levels in the body.
• Caffeine may increase blood pressure and heart rate, working against the effects of Amlodipine, especially in high doses.
• No significant interaction with dairy products, but they may slightly delay absorption without affecting the overall effectiveness.

Amlodipine 10mg Tablets should be stored in a secure and dry location, preferably in their original container, at room temperature, away from direct sunlight, heat, and moisture. It is crucial to keep the medication out of children's reach to prevent accidental ingestion. Do not store it in the bathroom medicine cabinet or any other humid environment. Always check the expiration date on the packaging; if the medication has expired, do not use it and dispose of it properly. When disposing of unused or expired tablets, do not throw them in the trash or flush them down the toilet. Consult your pharmacist or local waste management authority for guidance on safe disposal practices to minimize potential environmental harm.

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Following are the quick tips for Amlodipine 10mg Tablet:

• Consult your doctor for the correct dosage and duration of treatment.
• Take the tablet at the same time each day to maintain consistent blood levels.
• Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
• Avoid consuming grapefruit or grapefruit juice while on this medication.
• Inform your doctor about all medications/supplements you are taking.
• Do not stop taking the medication without consulting your doctor.
• Store the tablets at room temperature, away from moisture and direct sunlight.
• Regularly monitor your blood pressure and report any changes to your doctor.