One-Alpha (0.5mcg) 30 Capsules

Alfacalcidol, the active ingredient in the 0.5 mcg capsule, is a synthetic analog of vitamin D. Its mechanism of action involves mimicking the effects of naturally occurring vitamin D metabolites in the body. Alfacalcidol is a prodrug that undergoes metabolic activation in the liver, where it is converted into its active form, 1,25-dihydroxyvitamin D (calcitriol). This active metabolite binds to the vitamin D receptors (VDRs) present in various target tissues, primarily the intestines, bones, and kidneys. By activating these receptors, alfacalcidol promotes intestinal calcium and phosphate absorption, enhances bone mineralization, and regulates calcium and phosphate homeostasis. It stimulates the production of calcium-binding proteins, increases osteoclast activity, and inhibits parathyroid hormone (PTH) secretion, thereby playing a crucial role in maintaining normal calcium levels and promoting bone health.

Alfacalcidol 0.5mcg

Vitamin D analogue

Capsule

The following are the uses of Alfacalcidol 0.5mcg Capsule:

• Used for treating and preventing low levels of calcium in the blood, often caused by kidney or parathyroid gland issues.
• Used for managing calcium deficiency in conditions like hypoparathyroidism, where the body produces too little parathyroid hormone.
• Used for supporting calcium absorption and maintaining healthy calcium levels in patients with kidney failure.
• Used for treating bone pain and weakening associated with kidney disease or calcium deficiency.
• Used for preventing and treating rickets, a condition causing soft and weak bones in children due to vitamin D deficiency.
• Used for managing bone health in individuals with conditions affecting calcium absorption.
• Used for promoting bone strength and reducing the risk of fractures in certain medical situations.

In the case of an overdose of Alfacalcidol 0.5mcg Capsules, the patient may experience symptoms such as nausea, vomiting, weakness, and increased urination. Prompt medical attention is necessary to manage the overdose effectively. Treatment may involve supportive care, monitoring of vital signs, and addressing any electrolyte imbalances. It is crucial to seek medical help immediately and provide the healthcare provider with information about the quantity ingested.

In the case of a missed dose of Alfacalcidol 0.5mcg Capsule, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for advice, as they may need to adjust your dosage or provide further instructions. It is important to adhere to the prescribed dosage and consult a healthcare professional if you have any concerns.

To take Alfacalcidol 0.5mcg Capsule, swallow the capsule whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Here are the conditions and situations when Alfacalcidol 0.5mcg Capsule should not be taken:

• Should not be used in individuals with a known allergy to Alfacalcidol or any vitamin D-related compounds.
• Contraindicated in patients with high calcium levels in the blood (hypercalcemia) or those with evidence of vitamin D toxicity.
• Not recommended for individuals with impaired kidney function or kidney disease, as it can lead to excessive calcium accumulation.
• Should be avoided in patients with uncontrolled high blood calcium levels (hyperparathyroidism).
• Not suitable for individuals with a history of calcium-containing kidney stones.
• Contraindicated during pregnancy, especially in the first trimester, unless the potential benefits outweigh the risks.
• Should not be used in children without proper medical supervision and monitoring.
• Avoid using Alfacalcidol if you have a condition that causes excessive calcium absorption from the intestines.

The side effects of Alfacalcidol 0.5mcg Capsule may include:

• Nausea and vomiting.
• Constipation or diarrhea.
• Loss of appetite.
• Dry mouth.
• Increased thirst and frequent urination.
• Muscle or joint pain.
• Weakness or fatigue.
• Elevated calcium levels in the blood (hypercalcemia), which may cause symptoms like confusion, excessive thirst, and frequent urination.

Following are the precautions and warnings for Alfacalcidol 0.5mcg Capsule:

• Patients with a known hypersensitivity or allergy to Alfacalcidol or any of its components should not take this medication.
• Regular monitoring of calcium and phosphate levels in the blood is necessary during treatment, and dosage adjustments may be required based on the results.
• Caution should be exercised in patients with kidney disease, as Alfacalcidol is primarily metabolized by the kidneys, and impaired kidney function may affect its elimination.
• Individuals with a history of kidney stones or metabolic bone disease should be closely monitored, as Alfacalcidol can affect calcium and phosphate metabolism.
• Not recommended for individuals with uncontrolled hypercalcemia (high blood calcium levels), as it may exacerbate the condition.
• Elderly patients may be more susceptible to the effects and side effects of Alfacalcidol, and dosage adjustments might be necessary.
• Alfacalcidol should be used with caution in pregnant and breastfeeding women only if the potential benefits outweigh the risks.
• It is important to maintain adequate hydration while taking Alfacalcidol to minimize the risk of kidney complications.

Following are the drug interactions for Alfacalcidol 0.5mcg Capsule:

• Concurrent use with other vitamin D analogs or calcium supplements may lead to hypercalcemia, requiring close monitoring of calcium levels.
• Anticonvulsants like phenytoin and phenobarbital can reduce the effectiveness of Alfacalcidol by increasing its metabolism, potentially requiring dosage adjustments.
• Thiazide diuretics, when used with Alfacalcidol, may increase the risk of hypercalcemia and should be monitored closely.
• Corticosteroids can decrease the intestinal absorption of vitamin D, thus potentially reducing the efficacy of Alfacalcidol.
• Alfacalcidol may interact with digoxin, leading to increased risk of cardiac arrhythmias, and regular monitoring of digoxin levels is advised.
• Antacids containing magnesium or aluminum can decrease the absorption of Alfacalcidol, so they should be taken at different times.
• The effectiveness of Alfacalcidol may be reduced by cholestyramine, which can bind to the drug in the intestine, decreasing its absorption.

Following are the food interactions to be aware of when taking Alfacalcidol 0.5mcg Capsule:

• Avoid consuming foods rich in vitamin D and calcium, such as fatty fish, egg yolks, and dairy products, as excessive intake may lead to hypercalcemia.
• Grapefruit and grapefruit juice should be limited as they can affect the metabolism of Alfacalcidol, potentially leading to increased blood levels and side effects.
• Alcohol consumption should be minimized as it can negatively impact bone health and may interfere with the absorption of Alfacalcidol.
• Avoid high-fiber foods like whole grains and leafy greens temporarily as they can bind with Alfacalcidol, reducing its absorption.
• Limit the intake of foods containing oxalic acid (spinach, rhubarb) and phytic acid (legumes, whole grains) as they can hinder calcium absorption.
• Ensure adequate hydration to prevent dehydration, which can affect kidney function and calcium metabolism.
• Maintain a balanced diet, including moderate amounts of protein, to support the proper utilization of Alfacalcidol and promote overall health.
• Follow the dietary instructions provided by your healthcare professional, as individual needs may vary.

Alfacalcidol 0.5mcg Capsules should be stored in a dry and cool place, preferably at room temperature, ensuring protection from direct sunlight and moisture. The original packaging should be tightly sealed to maintain its integrity and prevent contamination. It is crucial not to expose the capsules to extreme temperatures, so avoid storing them near heat sources like ovens or radiators. Always check the expiration date, and for proper disposal, do not flush or pour the medication down the drain; instead, consult a pharmacist or healthcare professional for safe disposal practices. Keep the capsules out of children's reach to prevent accidental consumption.

Following are the quick tips for Alfacalcidol 0.5mcg Capsule:

• Take the capsule as directed by your doctor, typically once daily or as instructed.
• Swallow the capsule whole with a full glass of water, preferably at the same time each day.
• You can take it with or without food, but maintaining consistency is essential.
• Avoid breaking, crushing, or chewing the capsule; take it as a whole.
• If you have difficulty swallowing capsules, discuss alternative options with your pharmacist.
• Do not miss doses; ensure regular intake for effective results.
• Store the medication at room temperature, away from direct sunlight and moisture.