One Alpha (0.25mcg) 100 Capsules

Alfacalcidol, also known as 1-alpha-hydroxyvitamin D, has a mechanism of action that involves its activation into calcitriol, the active form of vitamin D, within the body. After administration, alfacalcidol is rapidly converted in the liver to calcitriol, which then binds to the vitamin D receptors (VDR) present in various target tissues. This binding triggers a cascade of intracellular events, primarily influencing calcium and phosphate metabolism. Calcitriol promotes intestinal absorption of calcium and phosphate, increases renal tubular reabsorption of calcium, and mobilizes calcium and phosphate from bone. By regulating these processes, alfacalcidol helps maintain calcium and phosphate homeostasis, which is crucial for proper bone mineralization and overall skeletal health. Its ability to modulate calcium levels also impacts muscle function and the nervous system.

Alfacalcidol 0.25ug

Calcimimetic vitamin D analogue.

Capsule

The following are the uses of Alfacalcidol 0.25ug Capsule:

• Used for treating and preventing low levels of calcium or phosphate in the blood, often caused by kidney or parathyroid issues.
• Used for managing calcium deficiency in conditions like hypoparathyroidism, where the parathyroid glands produce too little hormone.
• Used for supporting calcium absorption in the body, particularly in kidney disease patients.
• Used for preventing and treating bone pain and bone diseases, such as rickets and osteomalacia.
• Used for maintaining healthy bone density and preventing fractures, especially in individuals with kidney problems.
• Used for regulating the metabolism of calcium and phosphorus, ensuring proper bone development and growth.
• Used for addressing vitamin D deficiency, which can lead to bone and muscle weakness.

In the case of an overdose of Alfacalcidol 0.25ug Capsules, immediate medical attention is required. Symptoms may include nausea, vomiting, weakness, and frequent urination. Promptly seek emergency care or contact a poison control center for guidance. It is important to provide healthcare professionals with the patient's medical history, the amount ingested, and the time of overdose to ensure appropriate treatment. Quick action can help prevent severe complications.

In the case of a missed dose of Alfacalcidol 0.25ug Capsule, it is important to take the medication as soon as you remember. If it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. However, do not take a double dose to make up for a missed one, as this may lead to potential side effects. If you miss multiple doses, contact your healthcare provider for advice on how to safely adjust your dosage and get back on track with your treatment plan.

To take Alfacalcidol 0.25ug Capsule, swallow the capsule whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Here are the situations or conditions when Alfacalcidol 0.25 μg Capsule should not be taken:

• Should not be used in patients with a known hypersensitivity or allergy to Alfacalcidol or any of its excipients.
• Contraindicated in patients with hypercalcemia (high levels of calcium in the blood).
• Not recommended for individuals with evidence of vitamin D toxicity.
• Avoid use during pregnancy, especially in the first trimester, unless clearly necessary.
• Should not be used in patients with impaired kidney function or kidney failure.
• Contraindicated in patients with hypercalciuria (high levels of calcium in urine) and calcium-containing kidney stones.
• Not suitable for individuals with conditions causing calcium to be deposited in the body's tissues (e.g., hyperparathyroidism, sarcoidosis).

The side effects of Alfacalcidol 0.25µg Capsule may include:

• Nausea and vomiting
• Constipation or diarrhea
• Loss of appetite
• Increased thirst and frequent urination
• Muscle weakness or bone pain
• Fatigue and dizziness
• Headache
• Elevated calcium levels in the blood (hypercalcemia)

Following are the precautions and warnings for Alfacalcidol 0.25ug Capsule:

• This medication should be used with caution in patients with a history of kidney disease, as it may require dosage adjustments under medical supervision.
• Regular monitoring of calcium and phosphorus levels in the blood is necessary while taking this medication to ensure they remain within normal limits.
• Patients with a known allergy or sensitivity to alfacalcidol or any of its components should not use this medication.
• Alfacalcidol may cause hypercalcemia (high calcium levels in the blood), so patients should be monitored for symptoms like nausea, vomiting, constipation, and increased thirst or urination.
• Patients with hyperparathyroidism should use this medication with caution as it may exacerbate the condition.
• Not recommended for individuals with vitamin D toxicity or those who have conditions causing high calcium levels in the blood.
• Elderly patients may be more susceptible to the effects of this medication, especially hypercalcemia, so close monitoring is essential.
• Pregnant and breastfeeding women should consult their doctor before taking Alfacalcidol, as it may have potential risks to the fetus or infant.

Following are the drug interactions for Alfacalcidol 0.25ug Capsule:

• Anticonvulsants like phenobarbital and phenytoin can reduce the effectiveness of Alfacalcidol.
• Thiazide diuretics may enhance the effect of Alfacalcidol, leading to hypercalcemia.
• Calcium supplements and other vitamin D products may cause excessive calcium levels when used concurrently with Alfacalcidol.
• Corticosteroids can increase the metabolism of vitamin D, requiring higher doses of Alfacalcidol.
• Mineral oil can interfere with the absorption of Alfacalcidol when taken orally.
• Digoxin toxicity risk may increase with Alfacalcidol, as it can cause hypercalcemia.
• Antacids containing aluminum or magnesium can reduce the absorption of Alfacalcidol.

Following are the food interactions for Alfacalcidol 0.25ug Capsule:

• Alfacalcidol may interact with calcium-rich foods like dairy products, calcium-fortified foods, and calcium supplements. Consuming excessive amounts of calcium-rich foods may lead to hypercalcemia.
• Vitamin D-fortified foods, such as certain types of milk, orange juice, and cereals, should be consumed in moderation as they can also contribute to increased vitamin D levels.
• Avoid excessive intake of foods rich in vitamin A, such as liver, cod liver oil, and certain fish, as Alfacalcidol can enhance the effects of vitamin A, potentially leading to toxicity.
• Grapefruit and grapefruit juice may affect the metabolism of Alfacalcidol, potentially altering its effectiveness. It's best to avoid or limit their consumption.
• Alcohol can increase the risk of kidney damage, especially in individuals with pre-existing kidney issues. It's advisable to limit or avoid alcohol consumption while taking Alfacalcidol.
• High-fiber foods may interfere with the absorption of Alfacalcidol. Ensure a balanced diet and consult a healthcare professional for personalized advice.
• Maintain a consistent intake of phosphorus-rich foods like meat, fish, and dairy, as Alfacalcidol can affect phosphorus levels. Regular monitoring is recommended.
• Avoid making significant dietary changes without consulting a healthcare provider, as this may impact the effectiveness of Alfacalcidol.

Alfacalcidol 0.25 mcg capsules should be stored in a cool, dry place, preferably at room temperature between 20-25°C (68-77°F). Protect the capsules from direct sunlight, heat, and moisture, and keep them in their original packaging to maintain their integrity. Do not store them in the bathroom or refrigerator. Always check the expiration date, and discard any capsules that have passed their expiry. Proper disposal is crucial; do not flush or pour the medication down the drain. Consult a pharmacist or local waste disposal company for guidance on safe disposal methods, ensuring that it is kept away from children and pets to prevent accidental exposure.

Following are the quick tips for Alfacalcidol 0.25ug Capsule:

• Swallow the capsule whole with water; do not crush or chew it.
• Take the capsule on an empty stomach, preferably 1-2 hours before or after meals.
• Maintain a consistent calcium intake through diet or supplements as advised by your doctor.
• Regularly monitor your calcium and phosphate levels as directed by your healthcare provider.
• Avoid taking other vitamin D supplements or calcium-rich antacids without medical advice.
• Do not double the dose to make up for a missed one; resume your regular schedule.
• Store the capsules in a cool, dry place, away from direct sunlight and moisture.