One Alpha (1mcg) 100 Capsules

Alfacalcidol, chemically known as 1α-hydroxyvitamin D2, is a synthetic analog of vitamin D. Its primary mechanism of action is to mimic the active form of vitamin D, calcitriol, by binding to the vitamin D receptors (VDR) in various target tissues. Upon binding, alfacalcidol directly or indirectly regulates the expression of numerous genes involved in calcium and phosphate homeostasis. It stimulates intestinal absorption of calcium and phosphorus, promoting the mineralization of bone. Alfacalcidol also enhances renal tubular reabsorption of calcium and phosphorus, further contributing to bone health. Additionally, it modulates the immune system and exhibits anti-inflammatory properties, which may contribute to its therapeutic effects in certain conditions. The activation of VDR by alfacalcidol influences cellular proliferation, differentiation, and apoptosis, potentially impacting various physiological processes beyond mineral metabolism.

Alfacalcidol 1mcg

Calcimimetic vitamin D analogue

Capsule

The following are the uses of Alfacalcidol 1mcg Capsule:

• Used for treating and managing low levels of calcium in the blood, often caused by kidney failure or low parathyroid hormone levels.
• Used for correcting calcium and phosphate imbalances in patients with chronic kidney disease.
• Used for preventing and treating rickets, a condition of softening and weakening of bones in children.
• Used for managing hypocalcaemia (low calcium) and secondary hyperparathyroidism in patients with severe renal impairment.
• Used for maintaining calcium levels in patients with hypoparathyroidism, a condition of underactive parathyroid glands.
• Used for improving calcium absorption and bone health in individuals with conditions like osteomalacia (softening of bones).
• Used for supporting calcium metabolism and bone mineralization in specific medical situations.

In the case of an overdose of Alfacalcidol 1mcg Capsules, it is crucial to act promptly. The severity of symptoms can vary, but immediate medical intervention is necessary. Seek emergency care, and provide healthcare professionals with details about the quantity ingested. They will likely induce vomiting or perform gastric lavage to remove the medication. Prompt action can help mitigate potential complications from this potent medication.

In the case of a missed dose of Alfacalcidol 1mcg Capsule, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you frequently miss doses, it is advisable to set reminders or use a pill organizer to help you stay on track with your medication regimen. Consult your healthcare provider if you have any concerns or if you miss multiple doses.

To take Alfacalcidol 1mcg Capsule, swallow the capsule whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions or circumstances when Alfacalcidol 1mcg Capsule should not be taken:

• Avoid using Alfacalcidol if you have a known allergy or hypersensitivity to Alfacalcidol or any of its components.
• Do not take this medication if you have high levels of calcium in your blood (hypercalcemia) or if you have evidence of vitamin D toxicity.
• Contraindicated in individuals with impaired kidney function or kidney failure.
• Should not be used in patients with hypervitaminosis D, a condition of excessive vitamin D in the body.
• Not recommended for individuals with hypercalciuria, a condition where excessive calcium is present in the urine.
• Avoid using Alfacalcidol if you have a condition called hyperparathyroidism, where the parathyroid gland produces too much hormone.
• Do not take this medication if you are experiencing calcification in soft tissues, such as blood vessels or kidneys.
• Alfacalcidol is not suitable for individuals with a history of calcium-containing kidney stones.

The side effects of Alfacalcidol 1mcg Capsule may include:

• Nausea and vomiting
• Weakness or fatigue
• Increased thirst and urination
• Muscle or joint pain
• Headache
• Loss of appetite
• Constipation
• Elevated calcium levels in the blood (hypercalcemia)

Following are the precautions and warnings for Alfacalcidol 1mcg Capsule:

• Do not take Alfacalcidol if you are allergic to any of its ingredients or vitamin D compounds.
• Patients with kidney disease or impaired kidney function should use this medication with caution as it may require dosage adjustments.
• Regular monitoring of calcium levels in the blood and urine is necessary during treatment.
• Alfacalcidol can cause hypercalcemia (high calcium levels), so avoid taking calcium supplements or vitamin D-rich foods in excess.
• Caution is advised in patients with a history of heart disease, as it may worsen calcium deposits in blood vessels.
• Pregnant and breastfeeding women should consult their doctor before taking this medication, as it may affect fetal bone development and calcium metabolism.
• Do not drive or operate heavy machinery if you experience dizziness or drowsiness as a side effect.
• Children and elderly patients should be closely monitored for side effects and dosage adjustments.

Following are the drug interactions for Alfacalcidol 1mcg Capsule:

• Calcium-containing products and calcium supplements may lead to hypercalcemia and hypercalciuria when used with Alfacalcidol.
• Thiazide diuretics can cause hypercalcemia and hypercalciuria when combined with this drug.
• Anticonvulsants like phenobarbital and phenytoin may reduce the effect of Alfacalcidol.
• Corticosteroids can decrease the effect of Alfacalcidol by increasing the catabolism of vitamin D.
• Mineral oil and orlistat can decrease the absorption of vitamin D and its derivatives, including Alfacalcidol.
• Alfacalcidol may increase the risk of digitalis toxicity when used with cardiac glycosides.
• Antacids containing aluminum and magnesium can reduce the absorption of Alfacalcidol.

Following are the food interactions to consider with Alfacalcidol 1mcg Capsule:

• Alfacalcidol can interact with calcium-rich foods like milk, cheese, and yogurt, as well as vitamin D-fortified foods. It is advisable to maintain a consistent diet and avoid sudden changes in calcium and vitamin D intake.
• Consuming excessive amounts of foods rich in vitamin D, such as fatty fish (salmon, mackerel), egg yolks, and liver, should be done cautiously as it may lead to increased vitamin D levels in the body.
• Grapefruit and grapefruit juice should be consumed in moderation, as they can affect the metabolism of Alfacalcidol, potentially altering its effectiveness.
• Alcohol may increase the risk of side effects such as kidney problems and high calcium levels in the blood. It is advisable to limit or avoid alcohol consumption during treatment.
• Maintain a balanced diet, as Alfacalcidol can affect calcium and phosphate metabolism. Avoid extreme dietary changes without medical advice.
• Avoid taking calcium supplements or vitamin D supplements without consulting your doctor to prevent excessive intake.
• Certain herbal teas or supplements containing St. John's Wort may affect the metabolism of Alfacalcidol and should be used cautiously.

Alfacalcidol 1mcg Capsules should be stored in a cool, dry area, preferably at room temperature, and protected from direct sunlight and moisture. Keep the capsules in their original packaging, ensuring the container is tightly sealed to maintain their integrity. It is crucial to avoid exposing the medication to extreme temperatures, so steer clear of storing it in hot or humid environments like bathrooms or near cooking appliances. Always check the expiration date before using the capsules, and never use them past their expiry. When it's time to dispose of the medication, do not flush or pour it down the drain. Instead, consult a pharmacist or healthcare professional for guidance on safe disposal practices to protect the environment. Keep the capsules out of children's reach to prevent accidental consumption.

Here are the quick tips for Alfacalcidol 1mcg Capsule:

• Take the capsule as directed by your doctor, typically once daily or as prescribed.
• Swallow the capsule whole with a glass of water; do not crush or chew.
• Consistency is key; take your dose at the same time each day.
• Ensure regular blood tests to monitor calcium and phosphate levels.
• Avoid taking other vitamin D supplements unless advised by your doctor.
• Inform your doctor about all medications you are taking to prevent drug interactions.
• Store the capsules in a cool, dry place, away from direct sunlight and moisture.