ONE ALPHA INJ 0.5ML

Alfacalcidol, the active ingredient in Alfacalcidol 0.5mcg Injection, is a synthetic analog of vitamin D. It exerts its therapeutic effects by mimicking the actions of naturally occurring vitamin D hormones in the body. Alfacalcidol undergoes metabolic activation in the liver and kidneys, where it is converted into its active form, 1,25-dihydroxyvitamin D. This active metabolite binds to vitamin D receptors in various target tissues, primarily the intestines, bones, and kidneys. By interacting with these receptors, Alfacalcidol promotes intestinal calcium absorption, enhances renal tubular reabsorption of calcium and phosphorus, and mobilizes calcium and phosphate from bone. This leads to increased serum calcium and phosphorus levels, which are essential for maintaining proper mineral homeostasis, promoting bone mineralization, and supporting various physiological processes dependent on calcium and vitamin D.

Alfacalcidol 0.5mcg

Calcitriol analogue.

Injection

The following are the uses of Alfacalcidol 0.5mcg Injection:

• Used for treating calcium deficiency caused by kidney failure.
• Used for managing calcium and phosphate imbalances in patients on dialysis.
• Used to prevent and treat bone pain and weakness associated with kidney disease.
• Used to support bone health and prevent fractures in patients with chronic kidney conditions.
• Used for managing secondary hyperparathyroidism in renal failure patients.
• Used to improve calcium absorption and bone mineralization.
• Used to reduce the risk of bone-related complications in specific kidney disorders.

In the case of an overdose of Alfacalcidol 0.5mcg Injection, symptoms may include nausea, vomiting, muscle weakness, and a rapid heartbeat. Promptly seek medical attention if an overdose is suspected. The doctor may recommend monitoring vital signs and administering intravenous fluids to support the body's functions. Treatment may also involve addressing specific symptoms to prevent further complications. It is crucial to act quickly to minimize the risks associated with an overdose.

In the case of a missed dose of Alfacalcidol 0.5mcg Injection, it is important to administer the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or asking someone to help you remember to take your medication as prescribed. It is essential to maintain a consistent medication routine for optimal effectiveness.

To administer Alfacalcidol 0.5mcg Injection, carefully follow the instructions provided by your healthcare professional, which typically involve injecting the prescribed dose under the skin or into a muscle, ensuring proper hygiene and using sterile techniques to prevent infection.

Here are the situations or conditions when Alfacalcidol 0.5mcg Injection should not be used:

• Do not use if you are allergic to Alfacalcidol or any other vitamin D analogues.
• Contraindicated in patients with high blood calcium levels (hypercalcemia) or high blood calcium in the urine (hypercalciuria).
• Should not be used in patients with uncontrolled high blood pressure (hypertension).
• Not suitable for individuals with kidney stones or a history of kidney disease.
• Avoid using Alfacalcidol if you have any type of calcium metabolism disorder.
• Contraindicated in patients with evidence of vitamin D toxicity.
• Do not use if you have a known sensitivity to any of the excipients in the injection.

The side effects of Alfacalcidol 0.5mcg Injection may include:

• Nausea and vomiting
• Loss of appetite
• Increased thirst
• Frequent urination
• Muscle or joint pain
• Weakness or fatigue
• Elevated calcium levels in the blood (hypercalcemia)
• Itching or skin rash

Following are the precautions and warnings for Alfacalcidol 0.5mcg Injection:

• This medication should be used with caution in patients with kidney disease, as it may require dosage adjustments under medical supervision.
• Regular monitoring of calcium and phosphate levels in the blood is essential during treatment.
• Patients with a history of hypercalcemia (high blood calcium levels) should be closely monitored as the medication can elevate calcium levels.
• Not recommended for individuals with vitamin D toxicity or those who are hypersensitive to alfacalcidol or any of its components.
• Alfacalcidol may interact with other medications; inform your doctor about all the medicines you are currently taking.
• Patients with a history of heart disease, kidney stones, or sarcoidosis should use this medication with caution and under medical supervision.
• Pregnant and breastfeeding women should consult their doctor as Alfacalcidol may affect the unborn child or pass into breast milk.
• If you experience any unusual symptoms or side effects, such as nausea, vomiting, weakness, or muscle pain, contact your doctor immediately.

Following are the drug interactions for Alfacalcidol 0.5mcg Injection:

• Barbiturates, phenytoin, and rifampicin can reduce the effectiveness of alfacalcidol by increasing its metabolism.
• Thiazide diuretics may enhance the effect of alfacalcidol and increase the risk of hypercalcemia.
• Antacids containing aluminum or magnesium can decrease the absorption of alfacalcidol when taken together.
• Calcium supplements or calcium-rich foods should be monitored to avoid excessive calcium intake.
• The effects of digoxin may be potentiated, requiring careful monitoring.
• Corticosteroids can increase the metabolism of vitamin D and its derivatives, including alfacalcidol.
• Bisphosphonates may have additive effects on calcium metabolism and should be used with caution.

Following are the food interactions for Alfacalcidol 0.5mcg Injection:

• Alfacalcidol can interact with high-calcium diets, including dairy products like milk, cheese, and yogurt. It may lead to elevated calcium levels in the blood.
• Foods rich in vitamin D, such as fatty fish (salmon, mackerel), egg yolks, and fortified foods, should be consumed in moderation as they can enhance the effects of Alfacalcidol.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of Alfacalcidol, potentially causing increased drug levels in the body.
• Avoid excessive alcohol consumption as it may impair the absorption and effectiveness of Alfacalcidol and increase the risk of side effects.
• High-phosphorus foods like cola drinks, beer, and certain processed meats may require monitoring as they can affect calcium metabolism.
• Maintain a balanced diet with consistent calcium and phosphorus levels to ensure the proper functioning of Alfacalcidol.
• Always consult your healthcare provider for personalized dietary advice while using Alfacalcidol.
• Staying hydrated is essential, but excessive fluid intake may require monitoring in some cases.

Alfacalcidol 0.5mcg Injection should be stored in a controlled environment, preferably in a cool and dry place, maintaining a temperature between 20-25°C (68-77°F). Protect the injection from direct sunlight, heat, and moisture, as exposure to these elements can degrade its potency. Always keep the medication in its original packaging, ensuring the seal is intact, to maintain sterility. When disposing of unused or expired Alfacalcidol injection, do not throw it in the trash or pour it down the drain. Contact your healthcare provider or pharmacist for guidance on proper disposal methods to ensure environmental safety. Keep this medication securely locked away from children and pets to prevent accidental exposure.

Following are the quick tips for Alfacalcidol 0.5mcg Injection:

• Administer the injection as directed by your doctor for effective treatment.
• Ensure the injection is prepared and administered by a healthcare professional.
• Alfacalcidol may be given by intramuscular or slow intravenous injection.
• Follow the prescribed dosage and schedule for optimal results.
• Regularly monitor calcium and phosphate levels during treatment.
• Do not stop the medication without consulting your doctor.
• Store the injection as directed on the package, away from direct sunlight and moisture.
• Inform your doctor about all medications you are taking to avoid potential interactions.