ONSTIL SYP 120ML

Ondansetron Hydrochloride 4mg/5ml Syrup/Suspension works primarily by blocking serotonin 5-HT3 receptors in the body. This mechanism is crucial in preventing nausea and vomiting, as it inhibits the signals transmitted from the vagus nerve and the chemoreceptor trigger zone (CTZ) in the brain, which are key mediators of these symptoms. By acting as a selective antagonist at these 5-HT3 receptors, ondansetron effectively reduces the activity of serotonin, a neurotransmitter that can trigger the vomiting reflex. This targeted action makes ondansetron a potent antiemetic, providing relief without significantly impacting other bodily functions.

Antiemetic

Suspension

The following are the uses of Ondansetron Hydrochlorid 4mg/5ml Syrup/Suspension:

• Used for preventing nausea and vomiting caused by chemotherapy and radiation therapy.
• Used for the treatment of post-operative nausea and vomiting.
• Used to manage nausea and vomiting associated with acute and chronic medical conditions.
• Used to relieve severe symptoms of motion sickness.
• Used for the prevention and treatment of nausea and vomiting during pregnancy.
• Used to manage symptoms of gastroenteritis, including vomiting and dehydration.
• Used to provide relief from cyclic vomiting syndrome.

To be used as per doctor's prescription

In the case of an overdose of Ondansetron Hydrochloride 4mg/5ml Syrup/Suspension, individuals may experience an increase in known side effects, including severe headaches, dizziness, and impaired coordination. Excessive vomiting and diarrhea can lead to dehydration and electrolyte imbalances. In severe cases, an overdose may result in irregular heart rhythms and seizures. Prompt medical intervention is essential, including contacting a healthcare professional or poison control center for guidance on appropriate treatment and monitoring.

In the case of a missed dose of Ondansetron Hydrochloride 4mg/5ml Syrup/Suspension, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a medication tracking app to help you stay on track.

To administer Ondansetron Hydrochloride 4mg/5ml Syrup/Suspension, shake the bottle well, then use the provided measuring device to extract the prescribed amount, and consume it orally, following the dosage instructions provided by your healthcare professional.

Following are the conditions/situations when Ondansetron Hydrochloride 4mg/5ml Syrup/Suspension should not be taken:

• Should not be given to children under 2 years of age.
• Contraindicated in individuals with a known allergy or hypersensitivity to Ondansetron or any of its components.
• Not recommended for patients with a history of Long QT Syndrome or other heart rhythm disorders.
• Should not be used in patients with severe liver impairment.
• Contraindicated during pregnancy, especially in the first trimester, unless the potential benefits outweigh the risks.
• Not suitable for individuals who have shown intolerance or adverse reactions to similar anti-nausea medications.
• Should be avoided in patients with severe gastrointestinal obstruction or ileus.
• Must not be administered to patients with a known or suspected blockage in the gastrointestinal tract.

Here are the possible side effects of Ondansetron Hydrochloride 4mg/5ml Syrup/Suspension:

• Headache
• Dizziness
• Constipation
• Fatigue
• Diarrhea
• Dry mouth
• Flushing or warmth sensation
• Abdominal discomfort
• Allergic reactions, such as rash or itching
• Rarely, irregular heartbeat or chest pain

Following are the precautions and warnings for Ondansetron Hydrochloride 4mg/5ml Syrup/Suspension:

• Not recommended for individuals with known hypersensitivity to Ondansetron or related compounds.
• Ondansetron should be used with caution in patients with liver or kidney impairment, as dosage adjustments may be necessary.
• This medication may cause dizziness or drowsiness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Alcohol consumption should be avoided as it may increase the risk of side effects.
• Patients with a history of heart problems should be monitored closely, as rare cases of QT prolongation have been reported.
• Elderly patients may be more susceptible to the side effects of this medication, and regular monitoring is advised.
• If symptoms persist or worsen, seek medical advice promptly.
• Always consult a healthcare professional before taking this medication, especially if you have any underlying medical conditions.

Following are the drug interactions for Ondansetron Hydrochloride 4mg/5ml Syrup/Suspension:

• Ondansetron may interact with other serotonin-modulating drugs, such as selective serotonin reuptake inhibitors (SSRIs) or monoamine oxidase inhibitors (MAOIs), increasing the risk of serotonin syndrome.
• It can reduce the absorption of certain medications like ciprofloxacin and itraconazole, leading to decreased effectiveness of these drugs.
• Concomitant use with tramadol may increase the risk of seizures.
• The effect of ondansetron can be decreased by medications that increase liver metabolism, such as carbamazepine or rifampicin.
• Caution is advised when combining with benzodiazepines, as it may enhance the sedative effects and impair respiratory function.
• Ondansetron may interact with phenytoin, potentially altering the levels of both drugs in the body.
• Drugs that prolong the QT interval, such as certain antiarrhythmics or antipsychotics, should be used cautiously due to the potential for QT prolongation and cardiac arrhythmias.

Following are the food interactions for Ondansetron Hydrochloride 4mg/5ml Syrup/Suspension:

• Ondansetron may cause grapefruit and grapefruit juice to increase its concentration in the blood, leading to higher drug exposure and potentially increasing the risk of adverse effects. It is best to avoid consuming grapefruit products while taking this medication.
• Alcohol consumption should be avoided as it can increase the risk of side effects such as dizziness, drowsiness, and impaired coordination. The combination may also lead to increased sedation.
• Fatty meals can affect the absorption of Ondansetron, potentially reducing its effectiveness. It is advisable to take the medication on an empty stomach or with a light meal to ensure optimal absorption.
• Caffeine-containing beverages like coffee, tea, or energy drinks may increase the likelihood of side effects such as nervousness, anxiety, and sleep disturbances. It is recommended to limit caffeine intake while using Ondansetron.
• Chocolate, especially dark chocolate, contains compounds that can interact with Ondansetron, potentially affecting its metabolism. It is advisable to consume chocolate in moderation to minimize any potential interactions.
• Avoid high-sodium foods, as Ondansetron may cause sodium and water retention, leading to swelling and increased blood pressure in some individuals.
• Consuming large amounts of sugar while taking Ondansetron may affect blood sugar levels, especially in diabetic patients. Monitoring blood glucose levels and adjusting dietary sugar intake is advisable.
• No significant interactions with dairy products have been reported, but it's best to follow healthcare provider's instructions regarding dietary restrictions.

Ondansetron Hydrochloride 4mg/5ml Syrup/Suspension should be stored in a cool and dry environment, preferably at room temperature, ensuring protection from light and moisture. The medication container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial not to expose the syrup to extreme temperatures, so avoid storing it in hot places like near a stove or inside a car during hot weather. Always refer to the expiration date on the packaging, and if the syrup is past its prime, do not flush it or pour it down the drain; instead, consult a pharmacist for safe disposal methods. Keep this medication away from children to prevent accidental consumption.

No

Following are the quick tips for Ondansetron Hydrochloride 4mg/5ml Syrup/Suspension:

• Consult a healthcare professional for proper dosage instructions, especially for children.
• Administer the syrup using an accurate measuring device to ensure the correct dose.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Check the expiration date before use and discard if expired.
• Do not freeze the syrup as it may affect its effectiveness.
• Inform your doctor about any other medications you are taking to avoid potential interactions.
• Contact your healthcare provider if you experience any unusual or persistent side effects.
• Avoid driving or operating heavy machinery if the syrup causes drowsiness or dizziness.