Ophth-Atropine (1%) 10ml Eye Ointment

Atropine Ointment exerts its effects primarily by inhibiting the muscarinic acetylcholine receptors in the eye. When applied topically to the eye, atropine, the active ingredient, competes with acetylcholine for binding to these receptors. By blocking the activation of muscarinic receptors, atropine causes mydriasis (dilation of the pupil) and cycloplegia (paralysis of the ciliary muscles). This action helps to prevent the eye from accommodating or focusing, which is useful in various ophthalmological examinations and treatments. The dilation of the pupil also allows better visualization of the retina and other internal structures of the eye during diagnostic procedures.

Atropine

Anticholinergic

Ointment

The following are the uses of Atropine Ointment:

• Used for dilating the pupil during eye examinations
• Used for treating certain eye conditions like amblyopia (lazy eye)
• Used for temporarily relieving eye strain and fatigue
• Used for preventing excessive eye watering and tearing
• Used for improving vision in conditions with narrow pupils
• Used for diagnostic purposes to examine the retina
• Used for managing eye inflammation and pain
• Used for treating certain types of strabismus (crossed eyes)

In the case of an overdose of Atropine Ointment, several symptoms may occur, including severe dryness of the mouth, throat, and skin, along with difficulty in urination. It can also lead to rapid heart rate, confusion, and even hallucinations. If an overdose is suspected, immediate medical intervention is necessary. Treatment may involve supportive care and managing the symptoms to prevent further complications. It is crucial to seek medical advice promptly to ensure appropriate treatment and monitoring.

In the case of a missed dose of Atropine Ointment, it is important to apply the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply extra ointment to make up for the missed dose, as this may lead to an overdose. If you miss multiple doses, contact your healthcare professional for advice on how to safely resume your treatment and adjust the dosing schedule. Remember, it is crucial to adhere to the prescribed dosing regimen for optimal effectiveness.

To apply Atropine Ointment, wash your hands, then gently apply a thin layer of the ointment directly to the affected eye(s) or as directed by your healthcare professional, typically one to three times a day, being careful not to touch the tube tip to any surface to avoid contamination.

Here are the situations or conditions when Atropine Ointment should not be used:

• Avoid using Atropine Ointment if you have a known allergy or sensitivity to atropine or any other belladonna alkaloids.
• Do not use this ointment if you have narrow-angle glaucoma or if you have a blockage in your stomach or intestines.
• Not suitable for individuals with a history of urinary retention or difficulty in urination.
• Contraindicated for infants and young children with spastic paralysis.
• Should not be used for the treatment of contact dermatitis or other skin conditions without a doctor's recommendation.
• Avoid using it if you have a skin infection or open wounds in the affected area.
• Do not use Atropine Ointment if you have a skin condition called atopic dermatitis.
• Not recommended for individuals with a history of systemic lupus erythematosus (SLE).

The side effects of Atropine Ointment may include:

• Dilated pupils (enlargement of the black center of the eye)
• Dry mouth and throat
• Increased heart rate
• Flushing or redness of the skin
• Dizziness or lightheadedness
• Blurred vision or difficulty focusing
• Skin irritation or rash at the application site
• Temporary increased sensitivity to light

Following are the precautions and warnings for Atropine Ointment:

• Avoid use in patients with known hypersensitivity to atropine or any other components of the ointment.
• Use with caution in patients with narrow-angle glaucoma, as it may increase intraocular pressure and worsen the condition.
• May cause blurred vision and sensitivity to light; avoid driving or operating machinery until vision clears.
• Prolonged use may lead to systemic absorption and anticholinergic side effects, including dry mouth, dizziness, or confusion.
• Use with caution in elderly patients, as they may be more susceptible to anticholinergic effects.
• Avoid contact with mucous membranes, open wounds, or broken skin to prevent excessive absorption.
• Not recommended for use in infants or young children without medical supervision due to increased sensitivity.
• Patients with urinary retention, gastrointestinal obstruction, or prostatic hypertrophy should use with caution.
• If irritation, allergic reaction, or worsening symptoms occur, discontinue use and seek medical advice.
• Pregnant or breastfeeding women should consult a healthcare provider before using atropine ointment.

Following are the drug interactions for Atropine Ointment:

• Atropine may interact with other anticholinergic medications, leading to increased side effects such as dry mouth, blurred vision, and urinary retention.
• It can reduce the effectiveness of gastrointestinal prokinetics like metoclopramide, as they have opposing actions.
• Concomitant use with certain medications that prolong QT interval (e.g., certain antiarrhythmics, antipsychotics) may increase the risk of cardiac arrhythmias.
• Atropine can decrease sweating, which may reduce the effectiveness of topical antiperspirants.
• Caution is advised when using Atropine with muscle relaxants, as it may enhance their effects and potentially lead to respiratory depression.
• It may interact with certain eye medications, affecting intraocular pressure, especially in patients with glaucoma.
• Atropine can increase the risk of hyperthermia when used with certain antipsychotic medications.

Following are the food interactions for Atropine Ointment:

• Alcohol-containing eye products should be avoided as they can cause irritation and potential damage to the eye tissues.
• Grapefruit and grapefruit juice consumption should be monitored as they can potentially interact with some eye medications, although specific interactions with Atropine Ointment are not well-documented.
• It is generally recommended to avoid eating or drinking immediately after applying eye ointments to prevent contamination and ensure proper absorption.
• Avoid spicy foods as they can cause eye irritation and discomfort, especially if you have sensitive eyes or pre-existing eye conditions.
• Consuming foods rich in Vitamin A and Omega-3 fatty acids can support eye health and potentially enhance the effectiveness of eye medications, including Atropine Ointment.
• Dairy products and high-fat meals may not directly interact with Atropine Ointment, but they can influence the absorption of other medications you may be taking.
• Always consult with your healthcare provider or pharmacist for specific dietary recommendations and potential food interactions based on your overall health condition and medication regimen.

Atropine Ointment should be stored carefully to maintain its integrity and effectiveness. Keep the ointment in a cool, dry place, preferably at room temperature, ensuring it is not exposed to direct sunlight or excessive heat. The original container should be tightly sealed to prevent contamination and maintain its quality. It is crucial not to store it in the bathroom or near any heat sources. Always be mindful of the expiration date, and if the ointment is no longer needed or has expired, proper disposal is essential. Do not dispose of it in sinks or toilets; instead, consult a pharmacist or healthcare professional for guidance on safe disposal methods. Keep the ointment away from children to prevent accidental contact or ingestion.

Following are the quick tips for Atropine Ointment:

• Wash your hands before and after applying the ointment to maintain hygiene.
• Clean and dry the affected area before application for better absorption.
• Apply a thin layer as directed, avoiding sensitive areas like eyes and mucous membranes.
• Do not cover the treated area with bandages unless advised by your doctor.
• Avoid excessive exposure to sunlight or UV rays while using the ointment.
• Store the ointment at room temperature, away from direct sunlight and moisture.
• Consult your doctor if symptoms persist or worsen despite using the ointment as directed.