Ophth-Oflox (0.3%) 3.5g Eye Oinment

Ofloxacin eye ointment primarily exerts its antibacterial effect through the inhibition of bacterial DNA gyrase, a type II topoisomerase enzyme essential for bacterial DNA replication, transcription, and repair. The drug binds to the A subunit of DNA gyrase, changing its conformation and inhibiting its ability to recombine broken strands of bacterial DNA. This action prevents the replication and transcription of bacterial DNA, ultimately leading to bacterial cell death. Ofloxacin is particularly effective against a broad spectrum of gram-negative and gram-positive bacteria commonly associated with eye infections, including Pseudomonas aeruginosa, Staphylococcus aureus, and various Streptococcus species. Its mechanism of action is rapid, and the drug is known for its ability to penetrate well into ocular tissues, providing effective concentrations at the site of infection.

Antibacterial Ointment

Ointment

The following are the uses of Ofloxacin Eye Ointment:

• Used for treating bacterial eye infections, including conjunctivitis and corneal ulcers.
• Used for reducing inflammation and preventing further damage to the eye.
• Used for clearing bacterial infections that cause redness, itching, and discharge.
• Used for post-operative eye care to prevent infections.
• Used for treating eye infections in patients with contact lens-related issues.
• Used for managing infections in cases of eyelid or eye surface injuries.
• Used for providing relief from symptoms associated with bacterial eye infections.

In the case of an overdose of Ofloxacin Eye Ointment, it is important to recognize that this medication is intended for external eye use only. If accidentally ingested, symptoms may include nausea, vomiting, and dizziness. Promptly seek medical advice and inform the healthcare professional about the amount of ointment used. Treatment for overdose may involve supportive care and monitoring of vital signs to ensure the individual's well-being.

In the case of a missed dose of Ofloxacin Eye Ointment, it is important to apply the medication as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply extra ointment to make up for the missed dose. If you miss multiple doses, consult your healthcare provider for guidance, as they may advise you to restart the medication or provide specific instructions for catching up on the missed applications. Remember, maintaining a consistent dosing schedule is crucial for the effectiveness of the treatment.

To apply Ofloxacin Eye Ointment, gently pull down the lower eyelid, place a thin strip of ointment along the inside of the eyelid, and close your eyes for 1-2 minutes to allow the medication to distribute evenly.

Following are the conditions/situations when Ofloxacin Eye Ointment should not be used:

• Do not use if you have a known allergy or sensitivity to Ofloxacin or other quinolone antibiotics.
• Avoid using this ointment if you have a history of hypersensitivity or severe reactions to similar medications.
• Not recommended for individuals with damaged or compromised corneas.
• Do not use if you have a viral or fungal infection in the eye(s), as Ofloxacin is only effective against bacterial infections.
• Contraindicated in patients with a history of tendon disorders or tendon rupture related to fluoroquinolone antibiotic use.
• Not suitable for children and adolescents under 18 years of age, as the safety and efficacy have not been established in this age group.
• Avoid using if you have a condition that affects your central nervous system, such as epilepsy or a history of seizures.

The side effects of Ofloxacin Eye Ointment may include:

• Stinging or burning sensation in the eyes
• Redness or swelling of the eyelids
• Itchy or watery eyes
• Blurred vision
• Eye discharge
• Increased sensitivity to light (photophobia)
• Eye pain or discomfort
• Allergic reactions, such as skin rash or itching.

Following are the precautions and warnings for Ofloxacin Eye Ointment:

• Avoid using if you have a known allergy to Ofloxacin or any other quinolone antibiotics.
• Do not wear contact lenses while using this medication to avoid further eye irritation.
• Wash your hands before and after applying the ointment to prevent contamination.
• Do not touch the tip of the tube to any surface to maintain sterility.
• Inform your healthcare provider if you have a history of eye infections or any eye-related medical conditions.
• Discontinue use and seek medical attention if you experience severe eye pain, vision changes, or signs of an allergic reaction.
• Keep out of reach of children and pets.

Following are the drug interactions for Ofloxacin Eye Ointment:

• Concomitant use with other topical ophthalmic drugs may result in increased ocular pressure.
• The absorption of Ofloxacin can be reduced by antacids containing magnesium or aluminum, or with sucralfate, iron, or zinc supplements.
• The risk of tendonitis and tendon rupture is increased when used with corticosteroids.
• Ofloxacin may enhance the effects of warfarin and other oral anticoagulants, requiring close monitoring of prothrombin time.
• The effectiveness of live bacterial vaccines (e.g., typhoid vaccine) may be reduced when administered during treatment with Ofloxacin.
• Theophylline levels may be increased, potentially leading to theophylline toxicity.
• The risk of central nervous system stimulation and possible convulsions may increase when used with xanthine derivatives.

Following are the food interactions for Ofloxacin Eye Ointment:

• Ofloxacin should be used with caution in patients who consume caffeine, as it can increase the risk of central nervous system stimulation and lead to side effects like restlessness and insomnia.
• Avoid alcohol consumption during the treatment period, as it can cause temporary blurring of vision and reduced alertness.
• Dairy products like milk and yogurt may decrease the absorption of Ofloxacin when taken orally, but this is not a concern when applied topically to the eyes.
• Avoid grapefruit and grapefruit juice, as they can affect the metabolism of certain medications and potentially increase the levels of Ofloxacin in the body.
• Consuming foods high in vitamin K, such as leafy green vegetables, may be recommended to maintain normal blood clotting, as Ofloxacin can interfere with blood clotting factors.
• There is no known interaction with herbs or supplements, but always inform your healthcare provider about any herbal supplements you are taking.
• Stay well-hydrated by drinking plenty of fluids to maintain overall eye health during the treatment process.

Ofloxacin Eye Ointment should be stored with care to maintain its effectiveness and safety. Keep the ointment in a cool, dry place, preferably at room temperature, ensuring it is protected from direct sunlight and moisture. Store it in its original container with the lid tightly secured to prevent contamination. Avoid exposing the ointment to extreme temperatures, such as in the bathroom or near heat sources, as this can impact its quality. Always check the expiration date before application, and never use the ointment beyond its expiry. For proper disposal, do not flush or pour it down the drain; instead, consult a pharmacist or healthcare professional for guidance on safe disposal methods. Keep the ointment out of children's reach to prevent accidental contact or ingestion.

Following are the quick tips for Ofloxacin Eye Ointment:

• Wash your hands thoroughly before applying the ointment to ensure cleanliness.
• Pull the lower eyelid down to create a small pocket and apply a thin layer of ointment inside.
• Avoid touching the tip of the tube to your eye or any surface to prevent contamination.
• Close your eye gently after application and avoid rubbing it.
• Use the ointment as directed by your doctor, completing the full course of treatment.
• If you wear contact lenses, remove them before application and wait at least 15 minutes after using the ointment before reinserting them.
• Store the ointment at room temperature, away from direct sunlight and moisture.