Opt-D (25000IU) 4 Softgel Capsule

Cholecalciferol, also known as vitamin D3, has a specific mechanism of action. It is a prohormone that primarily supports calcium and phosphate homeostasis in the body. When Cholecalciferol is ingested, it undergoes two hydroxylation reactions in the liver and kidneys to become its active form, calcitriol (1,25-dihydroxyvitamin D3). Calcitriol acts as a hormone, binding to the vitamin D receptors (VDRs) located in various tissues, including the intestines, bones, and kidneys. This binding activates specific genes that regulate calcium and phosphate metabolism. In the intestines, it increases calcium and phosphate absorption, promoting bone mineralization. In the kidneys, it stimulates calcium reabsorption and phosphate excretion, maintaining proper mineral balance. This mechanism is crucial for bone health, as it ensures an adequate supply of calcium and phosphate for bone development and maintenance.

Cholecalcifero 25,000iu

Vitamin D3 Supplement

Capsule

The following are the uses of Cholecalcifero 25,000iu Capsule:

• Used for treating and preventing low levels of calcium and phosphate in the blood, often caused by disorders related to vitamin D deficiency.
• Used for managing conditions like rickets, osteomalacia, and familial hypophosphatemia.
• Used for aiding in the absorption of calcium, which is essential for the development and maintenance of strong bones.
• Used for supporting immune function and overall health.
• Used for addressing vitamin D deficiency due to limited sun exposure, certain medical conditions, or dietary restrictions.
• Used for managing chronic kidney disease and aiding in the regulation of calcium and phosphate levels.
• Used for optimizing bone health during specific stages of life, such as menopause or aging.
• Used for preventing falls and fractures in older adults by maintaining bone density.

In the case of an overdose of Cholecalciferol 25,000IU capsules, symptoms may include nausea, vomiting, weakness, and frequent urination. Excessive vitamin D can lead to elevated calcium levels in the blood, causing potential complications. Seek medical advice if you suspect an overdose, as treatment may involve supportive care and monitoring. Promptly contact a healthcare professional or a poison control center for guidance on managing any adverse effects and for further instructions regarding the specific steps to take.

In the case of a missed dose of Cholecalciferol 25,000 IU Capsule, it is important to take the dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one. Never double the dose to make up for a forgotten one. If you frequently miss doses, consider setting an alarm or using a pill organizer to help you stay on track. It's best to consult your healthcare professional for advice on managing missed doses to ensure the medication's effectiveness.

To take Cholecalciferol 25,000 IU capsules, swallow the capsule whole with a glass of water, preferably with a meal, as directed by your healthcare professional, usually once a week or as instructed.

Following are the conditions/situations when Cholecalciferol 25,000iu Capsule should not be taken:

• Should not be used in individuals with a known allergy to vitamin D or any of its components.
• Contraindicated in individuals with high levels of calcium in their blood (hypercalcemia) or those with conditions that cause excessive calcium absorption.
• Not recommended for patients with kidney stones or conditions that increase the risk of high calcium levels, such as sarcoidosis or hyperparathyroidism.
• Should not be used in individuals with a history of vitamin D toxicity.
• Contraindicated during hypervitaminosis D (excessive vitamin D levels).
• Not suitable for those with impaired kidney function or kidney disease.
• Avoid in patients with a history of hypercalciuria (high calcium levels in urine).

The side effects of Cholecalciferol 25,000 IU Capsule may include:

• Nausea and vomiting
• Constipation or diarrhea
• Abdominal pain
• Dry mouth
• Increased thirst
• Fatigue and weakness
• Muscle or bone pain
• Confusion or disorientation

Following are the precautions and warnings for Cholecalciferol 25,000 IU Capsule:

• Cholecalciferol should be used with caution in patients with a history of hypercalcemia, as it can increase calcium levels in the blood.
• Patients with kidney stones or a history of kidney disease should be monitored regularly, as this medication can affect kidney function.
• It may cause an increase in calcium levels, leading to hypercalcemia, especially in individuals with conditions like hyperparathyroidism or sarcoidosis.
• Regular monitoring of calcium levels is necessary, particularly for those on long-term therapy or with a history of kidney disease.
• Elderly patients may be more susceptible to hypercalcemia, so dosage adjustments might be required.
• Not recommended for individuals with vitamin D toxicity or those who have a hypersensitivity to cholecalciferol or any of its excipients.
• Cholecalciferol can interact with certain medications, such as digoxin and thiazide diuretics, so patients should inform their healthcare provider of all medications they are taking.
• Pregnant and breastfeeding women should consult their doctor as the dosage should be adjusted according to individual needs.

Following are the drug interactions for Cholecalciferol 25,000 IU Capsule:

• Anticonvulsants like phenobarbital, phenytoin, and carbamazepine can reduce vitamin D levels, requiring increased monitoring.
• Cholestyramine and colestipol can decrease the absorption of vitamin D, leading to reduced effectiveness.
• Thiazide diuretics may increase calcium levels, and concurrent use with vitamin D may require monitoring for hypercalcemia.
• Corticosteroids (e.g., prednisone) may decrease calcium absorption, potentially requiring higher vitamin D doses.
• Orlistat, a weight-loss medication, can reduce the absorption of fat-soluble vitamins like vitamin D.
• Aluminum-containing antacids may decrease vitamin D absorption, affecting bone metabolism.
• Mineral oil, often used as a laxative, can interfere with the absorption of fat-soluble vitamins, including vitamin D.

Following are the food interactions for Cholecalciferol 25,000 IU Capsule:

• Avoid excessive consumption of foods rich in vitamin D, such as fatty fish (salmon, mackerel), egg yolks, and fortified dairy products, as it may lead to vitamin D toxicity.
• Consuming high-fat meals can enhance the absorption of vitamin D, ensuring better utilization of the supplement.
• Grapefruit juice should be consumed with caution as it may affect the metabolism of vitamin D, potentially leading to increased blood levels.
• Dairy products like milk and yogurt can enhance the absorption of vitamin D due to their calcium content, aiding in bone health.
• Avoid excessive alcohol intake as it may interfere with vitamin D metabolism and reduce its effectiveness.
• Leafy green vegetables, when consumed with the supplement, can provide additional benefits due to their vitamin K content, promoting bone and heart health.
• Certain mineral-rich foods like spinach and rhubarb may interfere with vitamin D absorption if consumed in large quantities due to their oxalate content.
• Always consult a healthcare professional for personalized advice, especially if you have specific dietary preferences or medical conditions.

Cholecalciferol 25,000iu Capsules should be stored in a cool, dry place, preferably at room temperature between 20-25°C (68-77°F). Protect the capsules from excessive heat, moisture, and direct sunlight, as these conditions can degrade the medication. Keep the capsules in their original container, tightly sealed, to maintain their integrity and prevent exposure to environmental factors. It is crucial not to store them in the bathroom or kitchen, where humidity and temperature fluctuations can occur. Always check the expiration date, and dispose of any unused or expired capsules responsibly. Do not throw them into the trash or flush them, but consult a pharmacist or healthcare professional for guidance on proper disposal methods to ensure environmental safety. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Cholecalciferol 25,000iu Capsule:

• Consult your doctor for dosage instructions based on your vitamin D levels and health condition.
• Take the capsule with a meal to enhance vitamin D absorption.
• Consume it regularly to maintain healthy vitamin D levels.
• Do not exceed the prescribed dosage without medical advice.
• Store the capsules in a cool, dry place, away from direct sunlight.
• Inform your doctor about all medications you are taking to avoid interactions.
• Pregnant and breastfeeding women should consult their healthcare provider for personalized advice.
• Seek medical attention if any adverse effects occur or if you have underlying health conditions.