Optadex-N (0.1/0.35%) 5ml Eye Drops

Dexamethasone, a potent synthetic corticosteroid, exerts its anti-inflammatory and immunosuppressive effects by binding to cytoplasmic glucocorticoid receptors, leading to the regulation of gene expression. This results in the suppression of various pro-inflammatory mediators, including cytokines and enzymes involved in the inflammatory process. Neomycin Sulfate, an aminoglycoside antibiotic, works by binding to the bacterial ribosome, inhibiting protein synthesis, and subsequently leading to bacterial cell death. When used together in eye drop formulations, dexamethasone provides rapid relief from inflammation and associated symptoms, while neomycin sulfate helps prevent or treat secondary bacterial infections that may accompany ocular inflammation.

Dexamethasone, Neomycin Sulphate

Corticosteroid, Antibiotic

Drop

The following are the uses of Dexamethasone, Neomycin Sulphate Drop:

• Used for reducing inflammation and suppressing the immune response in the eye.
• Used to treat eye infections, especially those caused by bacteria.
• Used for managing eye conditions like conjunctivitis, uveitis, and corneal ulcers.
• Used to prevent and treat eye infections after eye surgeries or injuries.
• Used to provide relief from eye redness, itching, and discomfort.
• Used to reduce swelling and promote healing in eye injuries.
• Used for short-term treatment of acute eye issues.
• Used to prevent and manage eye allergies.

In the case of an overdose of Dexamethasone, symptoms may include increased heart rate, high blood pressure, and anxiety. In severe cases, it can lead to cardiac arrest. For Neomycin Sulphate Drops, an overdose may result in nausea, vomiting, and potential kidney damage. If either of these medications is ingested in excess, seek medical assistance promptly. Prompt medical intervention is vital to mitigate potential health risks.

In the case of a missed dose of Dexamethasone, it is important to apply the eye drops as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra drops to make up for the missed dose. For Neomycin Sulphate Drops, if you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

To use Dexamethasone, Neomycin Sulphate Eye Drops, gently tilt your head back, pull the lower eyelid down to create a pocket, and hold the dropper above the eye; release one drop into the pocket, blink gently to allow the drop to spread over the eye, and keep your eyes closed for 1-2 minutes to ensure the medication is absorbed.

Following are the conditions when Dexamethasone, Neomycin Sulphate Eye Drops should not be used:

• Should not be used if you have a known allergy or hypersensitivity to dexamethasone, neomycin, or any other ingredients in the eye drops.
• Contraindicated in individuals with viral, fungal, or tubercular infections of the eye.
• Not suitable for patients with untreated bacterial eye infections.
• Should not be used if you have a history of corneal ulcers or perforations.
• Avoid using these eye drops if you have a known allergy to other corticosteroids or aminoglycoside antibiotics.
• Not recommended for individuals with a history of herpes simplex keratitis.
• Contraindicated in patients with vaccinia or varicella (chickenpox or shingles).
• Should not be used in individuals with a history of ocular surgery or trauma until the cornea has healed.

The side effects of Dexamethasone, Neomycin Sulphate Eye Drop may include:

• Eye irritation or redness
• Blurred vision or changes in vision
• Increased eye pressure (glaucoma)
• Eye discomfort or itching
• Sensitivity to light (photophobia)
• Dry eyes or increased tearing
• Allergic reactions, such as rash, itching, or swelling around the eyes

Following are the precautions and warnings for Dexamethasone, Neomycin Sulphate Eye Drops:

• Avoid using these eye drops if you are allergic to any of their ingredients, including dexamethasone or neomycin sulfate.
• Do not wear contact lenses while using these eye drops, and wait for the recommended time after application before reinserting them.
• If you have a history of eye infections, injuries, or surgeries, inform your doctor before using these drops.
• Prolonged use of these eye drops may lead to increased intraocular pressure, glaucoma, or cataract formation. Regular eye pressure checks are necessary.
• These eye drops may cause temporary blurred vision. Avoid driving or operating heavy machinery until your vision is clear.
• Do not touch the dropper tip to any surface as it may contaminate the solution.
• Keep out of reach of children and pets. Store at room temperature, away from direct sunlight.

Following are the drug interactions for Dexamethasone, Neomycin Sulphate Drop:

• Dexamethasone may interact with other immunosuppressants, increasing the risk of infections and suppressing the immune system further.
• Concomitant use with other ototoxic medications (e.g., certain antibiotics or diuretics) can enhance the risk of hearing damage.
• May reduce the effectiveness of live vaccines, as it suppresses the immune response.
• Anticonvulsants like phenytoin or carbamazepine can increase the metabolism of Dexamethasone, potentially reducing its effectiveness.
• Neomycin may interact with other aminoglycoside antibiotics, increasing the risk of kidney damage and hearing loss.
• May affect the absorption of oral medications, particularly when administered concurrently.
• Some diuretics, such as furosemide, may enhance the risk of ototoxicity when used with Neomycin.

Following are the food interactions for Dexamethasone, Neomycin Sulphate Drop:

• Avoid consuming grapefruit or grapefruit juice as it may decrease the breakdown of dexamethasone in the liver, potentially leading to increased drug levels and a higher risk of side effects.
• Limit alcohol consumption as it can increase the risk of stomach bleeding and liver damage when combined with dexamethasone.
• Neomycin can reduce the absorption of certain nutrients, especially vitamin K, so ensure you maintain a balanced diet rich in vitamins and minerals.
• Avoid high-sodium foods as dexamethasone can cause sodium retention, leading to fluid retention and increased blood pressure.
• Limit the intake of foods containing live bacteria, such as probiotic supplements or fermented foods, as neomycin is an antibiotic and may reduce their effectiveness.
• Avoid caffeine or limit its consumption as it can exacerbate side effects like insomnia and nervousness, especially when taken with dexamethasone.
• Ensure adequate hydration by drinking plenty of fluids, as dexamethasone can cause fluid shifts and electrolyte imbalances.
• Be cautious with sugary foods and beverages, as dexamethasone can increase blood sugar levels, especially in diabetic patients.

Dexamethasone, Neomycin Sulphate Drops should be stored in a cool and dry place, preferably at room temperature, ensuring it is not exposed to direct sunlight or extreme temperatures. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. It is crucial not to store it in bathrooms or near heat-emitting appliances. Regularly check the expiry date, and if the medication is no longer needed or has expired, do not flush it or pour it down the drain. Consult your pharmacist for safe disposal methods to protect the environment. Always keep medications securely locked away from children to prevent accidental consumption.

Following are the quick tips for this drops:

• Always take the medication as directed by your doctor, following the prescribed dosage and duration.
• Dexamethasone should be taken with food to reduce stomach irritation.
• Avoid consuming alcohol while on this medication as it may increase the risk of side effects.
• Inform your doctor about any other medications or supplements you are taking.
• Regularly monitor your blood sugar levels if you have diabetes.
• Do not stop taking the medication suddenly; follow your doctor's instructions for tapering the dose.
• Report any signs of infection, unusual weight gain, or changes in mood to your healthcare provider.
• Wash your hands thoroughly before using the eye drops to prevent contamination.
• Tilt your head back, gently pull down your lower eyelid, and apply the prescribed number of drops into the eye.
• Avoid touching the dropper tip to your eye or any surface to maintain sterility.
• Close your eye gently and apply light pressure to the inner corner of the eye for better absorption.
• If using other eye medications, wait at least 5-10 minutes before applying them to prevent washout.
• Store the eye drops at room temperature, away from direct sunlight and moisture.
• Do not use the eye drops if the solution changes color or becomes cloudy.