OPTHA FLOX

Lomefloxacin, a synthetic fluoroquinolone antibiotic, exerts its bactericidal effect by targeting bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, and repair. This interference inhibits DNA synthesis and promotes the accumulation of double-stranded DNA breaks, ultimately leading to bacterial cell death. Specifically, lomefloxacin binds to the A subunit of DNA gyrase, preventing the re-ligation of cleaved DNA strands, which is required for the enzyme's function. This mechanism effectively disrupts the bacterial cell cycle, making it a potent treatment for various bacterial infections.

Lomefloxacin

Fluoroquinolone antibiotic

Ointment

The following are the uses of Lomefloxacin Ointment:

• Used for treating bacterial conjunctivitis, an inflammation or infection of the membrane lining the eyelids.
• Used to eliminate a wide range of bacteria that can cause eye infections.
• Used to treat acute otitis externa, a bacterial infection of the outer ear and ear canal.
• Used for its ability to penetrate and accumulate in high concentrations within infected tissues.
• Used to relieve symptoms such as redness, itching, and bacterial-associated inflammation.
• Used for its effectiveness against a variety of bacteria, including those resistant to other antibiotics.
• Used for post-operative eye infections, ensuring the eye heals without further complications.
• Used to prevent the spread of infection to other parts of the eye or nearby tissues.

In the case of an overdose of Lomefloxacin Ointment, it is important to recognize the potential severity of the situation. Overapplication or ingestion of the ointment may lead to an increased risk of adverse effects, particularly on the skin and eyes. Symptoms may include severe skin irritation, redness, and potential vision problems. It is crucial to seek medical advice promptly and inform healthcare professionals about the extent of the overdose for appropriate treatment and management.

In the case of a missed dose of Lomefloxacin Ointment, it is important to apply the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra ointment to make up for the missed application. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed, as they may advise you to restart the treatment or provide alternative instructions. It is crucial to follow the prescribed treatment plan for optimal effectiveness.

To apply Lomefloxacin Ointment, gently clean and dry the affected eye(s) before instilling one drop into the lower eyelid of each eye as directed by your healthcare professional, typically three to four times a day, while avoiding touching the dropper tip to any surface to prevent contamination.

Here is a list of conditions and situations when Lomefloxacin Ointment should not be used:

• Do not use if you have a known allergy or hypersensitivity to Lomefloxacin or other quinolone antibiotics.
• Avoid using Lomefloxacin Ointment if you have a history of tendon disorders or tendon rupture, especially with previous use of fluoroquinolone antibiotics.
• Contraindicated in patients with epilepsy or a history of seizures, as it may lower the seizure threshold.
• Not recommended for individuals with myasthenia gravis, as it may worsen muscle weakness.
• Avoid using if you have a history of cardiovascular problems, such as prolonged QT interval, heart rhythm disorders, or low potassium levels.
• Lomefloxacin Ointment should not be used in children and adolescents under 18 years of age, as it may affect bone and joint development.
• Do not use if you have a history of liver disease or impaired liver function.
• Avoid using on open wounds, severely inflamed skin, or extensive areas of broken skin.

The side effects of Lomefloxacin Ointment may include:

• Skin irritation or redness at the application site
• Itching or rash
• Dryness or peeling of the skin
• Burning or stinging sensation
• Swelling or inflammation
• Allergic reactions (hives, difficulty breathing, swelling of the face/lips/tongue)
• Increased sensitivity to sunlight

Following are the precautions and warnings for Lomefloxacin Ointment:

• Avoid contact with eyes and mucous membranes; if accidental contact occurs, immediately flush with water.
• Do not use Lomefloxacin Ointment if you are allergic to any of its ingredients; cross-sensitivity with other fluoroquinolones is possible.
• This medication is for external use only and should not be applied to open wounds or broken skin.
• It should not be used in children, pregnant or breastfeeding women, and individuals with a history of tendon disorders or epilepsy unless under medical supervision.
• Discontinue use and consult a doctor if irritation, severe redness, or swelling develops at the application site.
• Prolonged use may result in bacterial or fungal overgrowth, particularly with prolonged or repeated treatment.
• Keep out of reach of children and pets; store in a cool, dry place away from direct sunlight.

Following are the drug interactions for Lomefloxacin Ointment:

• Prolonged use of both can increase the risk of bacterial or fungal infections.
• These may reduce the absorption of oral lomefloxacin if taken simultaneously.
• Nonsteroidal anti-inflammatory drugs (NSAIDs), Can increase the risk of central nervous system (CNS) stimulation and seizures.
• Theophylline, Lomefloxacin may increase theophylline levels, potentially leading to toxicity.
• Probenecid, It can increase the concentration of lomefloxacin, increasing the risk of adverse effects.
• Sucralfate, May reduce the absorption of oral lomefloxacin if taken simultaneously.
• Multivalent cations, Iron, zinc, or magnesium supplements can decrease the absorption of lomefloxacin.

Following are the food interactions for Lomefloxacin Ointment:

• Lomefloxacin should be used with caution in patients who consume alcohol, as it may increase the risk of liver toxicity and side effects. Avoid excessive alcohol consumption.
• Grapefruit and grapefruit juice are best avoided as they can affect the metabolism of the drug, potentially increasing Lomefloxin levels in the body and leading to a higher risk of side effects.
• Dairy products like milk, yogurt, and cheese may interfere with the absorption of Lomefloxacin. Consider separating the intake of dairy products and medication by a few hours.
• Foods rich in caffeine, such as coffee, tea, and energy drinks, may increase the risk of caffeine-related side effects when combined with Lomefloxacin. Consider reducing caffeine intake.
• Avoid high-fat meals as they may slow down the absorption of Lomefloxacin, potentially affecting its effectiveness.
• Iron-rich foods like red meat, beans, and spinach might decrease the absorption of Lomefloxacin. It is advisable to separate the consumption of iron-rich foods and the medication.
• Vitamin and mineral supplements, especially those containing zinc, magnesium, or iron, may interfere with the absorption of Lomefloxacin. Take supplements at a different time than the medication.
• Always consult your healthcare provider for personalized advice regarding any specific dietary restrictions or adjustments needed while using Lomefloxacin Ointment.

Lomefloxacin Ointment should be stored in a cool and dry environment, preferably at room temperature, ensuring protection from direct sunlight and moisture. It is crucial to keep the ointment in its original packaging, securely sealed to maintain its integrity and prevent contamination. Extreme temperatures should be avoided, so refrain from storing it in hot areas like near stoves or inside bathrooms where humidity can be high. Always be mindful of the expiration date, and if the ointment is past its prime or no longer needed, proper disposal is essential. Do not dispose of it by flushing or pouring it down the drain; instead, consult a pharmacist or healthcare professional for guidance on safe disposal methods. Keep the ointment out of children's reach to prevent accidental exposure.

Following are the quick tips for Lomefloxacin Ointment:

• Wash your hands before and after applying the ointment to maintain hygiene.
• Ensure the affected area is clean and dry before application.
• Apply a thin layer of ointment, gently massaging it into the skin.
• Follow the prescribed dosage and duration of treatment as directed by your doctor.
• Avoid contact with eyes; if contact occurs, rinse thoroughly with water.
• Do not cover the treated area with bandages or tight clothing to allow it to breathe.
• Store the ointment at room temperature, away from direct sunlight and moisture.