Oratane (20mg) 30 Capsules

Isotretinoin works by targeting several factors that contribute to the development of acne. It is a retinoid, a synthetic derivative of Vitamin A, and it reduces sebaceous (oil) gland size and secretion, decreasing the amount of oil (sebum) on the skin. Isotretinoin also helps to normalize the shedding of skin cells, preventing the clogging of hair follicles, which is a primary cause of acne. Additionally, isotretinoin possesses anti-inflammatory properties and helps to reduce the growth of acne-causing bacteria (specifically Propionibacterium acnes). This combination of effects results in a significant reduction in acne lesions and prevents the formation of new ones.

Isotretinoin 20mg

retinoids

Capsule

The following are the uses of Isotretinoin 20mg Capsule:

• Treatment of severe, recalcitrant nodular acne that has not responded to other therapies.
• Management of cystic acne, which can cause scarring.
• Treatment of acne vulgaris in patients who require systemic therapy after topical treatments have failed.
• Used off-label for conditions like rosacea, especially in cases with severe inflammation or pustules.
• Effective in reducing oil production in the skin, leading to overall improvement in acne symptoms.

Following are the doses of Isotretinoin 20mg Capsule:

• The typical starting dose for severe acne is 0.5 mg per kg body weight per day, divided into two doses, taken with meals.
• For an average adult, this may amount to 20 mg to 40 mg per day, depending on body weight and the severity of the acne.
• The dose may be adjusted based on the response and tolerance, and it is usually taken for 15 to 20 weeks.
• In some cases, the dose may be increased to 1 mg per kg per day if the response is insufficient or if there is a need for a second course of treatment.

In case of an overdose of Isotretinoin 20mg Capsule, immediate medical attention should be sought. An overdose may lead to symptoms such as severe headache, nausea, vomiting, dizziness, or dry skin. If a large quantity is ingested, it is crucial to contact a healthcare provider or poison control center immediately. Do not attempt to induce vomiting or take any other action without medical guidance. Supportive care may be required to manage symptoms, but there is no specific antidote for isotretinoin overdose.

If you miss a dose of Isotretinoin 20mg Capsule, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time to make up for the missed dose, as this could increase the risk of side effects. Always follow the dosing instructions provided by your healthcare provider and consult them if you're unsure about how to proceed after missing a dose.

To use Isotretinoin 20mg Capsule, follow the instructions provided by your healthcare provider or as indicated on the prescription label. Typically, it should be taken once or twice daily, with food, to help reduce potential stomach upset. Swallow the capsule whole with a glass of water. Do not chew, crush, or break the capsule.

Following are the situations when Isotretinoin 20mg Capsule should not be used:

• Should not be used in individuals who are pregnant or planning to become pregnant due to the risk of severe birth defects.
• Contraindicated in patients who have a known allergy to Isotretinoin or any of its components.
• Should not be used in individuals with severe liver disease or high cholesterol/triglyceride levels.
• Contraindicated in patients with hypervitaminosis A or those with a history of mental health issues, including depression, suicidal thoughts, or behavior.
• Should not be used in individuals with a history of pancreatitis or excess alcohol consumption.

The side effects of Isotretinoin 20mg Capsule may include:

• Dry skin
• Chapped lips
• Dry eyes
• Nosebleeds
• Muscle or joint pain
• Temporary hair thinning
• Increased cholesterol or triglyceride levels
• Mood changes, including depression or anxiety
• Headaches
• Nausea or vomiting

If any of these side effects persist or worsen, consult your healthcare provider.

Following are the precautions and warnings for Isotretinoin 20mg Capsule:

• Should not be used in individuals who are pregnant or planning to become pregnant due to the high risk of birth defects.
• Contraindicated in breastfeeding women as it can pass into breast milk and harm the baby.
• Caution is advised in patients with a history of depression or mental health disorders, as Isotretinoin may worsen these conditions.
• Patients with liver disease or high cholesterol levels should be monitored closely during treatment, as the medication can affect liver function and lipid levels.
• Not recommended for individuals with a history of pancreatitis, as it may increase the risk of this condition.
• Avoid exposure to the sun and tanning beds, as Isotretinoin can make the skin more sensitive to UV radiation. Use sunscreen and protective clothing.
• It is important to avoid donating blood while on Isotretinoin and for at least one month after treatment, due to the risk of harm to a pregnant recipient.

Following are the drug interactions for Isotretinoin 20mg Capsule:

• Concomitant use with tetracycline antibiotics (e.g., doxycycline) may increase the risk of intracranial hypertension (increased pressure in the brain).
• Avoid using Isotretinoin with Vitamin A supplements or other retinoids, as this can lead to toxicity due to excessive levels of vitamin A in the body.
• Caution is required when Isotretinoin is used with medications that can affect liver function (e.g., alcohol, anticonvulsants), as it may exacerbate liver problems.
• Concurrent use with corticosteroids may increase the risk of developing osteoporosis or bone thinning.
• Isotretinoin may interact with oral contraceptives, so ensure the use of effective contraception to prevent pregnancy. If you are using birth control, consult your healthcare provider for guidance.
• It is important to avoid using Isotretinoin with other medications that may increase the risk of bleeding, such as warfarin, without careful monitoring.

Following are the food interactions for Isotretinoin 20mg Capsule:

• Avoid excessive intake of Vitamin A-rich foods (e.g., liver, fish oil, fortified foods), as this can increase the risk of vitamin A toxicity when combined with Isotretinoin.
• Alcohol consumption should be limited, as it can increase the risk of liver toxicity and other side effects when taken with Isotretinoin.
• It is advised to take Isotretinoin with food to improve absorption and reduce gastrointestinal discomfort. However, avoid taking it with high-fat meals as it can increase the risk of gastrointestinal side effects.
• Grapefruit and grapefruit juice should be avoided as they may alter the metabolism of certain medications, potentially leading to increased side effects.

Isotretinoin 20mg Capsule should be stored in a cool, dry place, away from moisture and heat. Keep the medication in its original container, tightly closed, and out of reach of children. It is important to store Isotretinoin at room temperature, typically between 20°C to 25°C (68°F to 77°F). Do not store Isotretinoin in the bathroom or any humid areas, as excessive moisture can affect the medication's effectiveness.When it comes to disposal, do not flush Isotretinoin down the toilet or pour it into drains unless instructed by a healthcare provider or local waste disposal guidelines. If you no longer need the medication or it has expired, take it to a pharmacy or a drug take-back program for safe disposal. Always follow the proper disposal instructions to prevent environmental contamination or accidental ingestion by others.

Following are the quick tips for Isotretinoin 20mg Capsule:

• Take Isotretinoin exactly as prescribed by your healthcare provider for optimal results.
• It is advised to take the medication with food to improve absorption.
• Do not crush, chew, or open the capsule; swallow it whole.
• Avoid sun exposure and use sunscreen, as Isotretinoin can make your skin more sensitive to the sun.
• Women of childbearing age should strictly follow contraception guidelines while taking Isotretinoin, as it can cause serious birth defects.
• Regular follow-up appointments with your healthcare provider are important to monitor for side effects.
• Do not donate blood while taking Isotretinoin and for at least 1 month after stopping the treatment.