ORBENIN 125MG SYP

Cloxacillin is a penicillin-based antibiotic that primarily targets bacteria. Its mechanism of action involves inhibiting the synthesis of bacterial cell walls. Specifically, Cloxacillin binds to and blocks the activity of enzymes called transpeptidases, which are crucial for cross-linking peptidoglycan strands in the bacterial cell wall. By disrupting this process, Cloxacillin weakens the cell wall structure, leading to cell lysis and the death of susceptible bacteria. This selective action makes Cloxacillin effective against various gram-positive bacteria, including penicillinase-producing strains, as it is resistant to breakdown by their beta-lactamases.

Cloxacillin 125MG

Penicillin antibiotic

Suspension

The following are the uses of Cloxacillin 125MG Syrup/Suspension:

• Used for treating bacterial infections such as pneumonia, bronchitis, and tonsillitis.
• Used for controlling the growth of bacteria in the body.
• Used for relieving symptoms like fever, cough, and difficulty breathing.
• Used for preventing the spread of bacterial infections in the respiratory tract.
• Used for managing skin and soft tissue infections, providing relief and promoting healing.
• Used for ensuring a complete course of treatment to prevent bacterial resistance.
• Used for children and infants, offering a palatable option for easy administration.
• Used for post-operative care to prevent and treat surgical site infections.

In the case of an overdose of Cloxacillin 125MG Syrup/Suspension, it is important to remain calm and take swift action. Contact a healthcare professional or a poison control center immediately for guidance. They will provide specific instructions based on the individual's age, weight, and the amount ingested. Prompt medical assessment and support are vital to ensure the best possible outcome and minimize any potential adverse effects.

In the case of a missed dose of Cloxacillin 125MG Syrup/Suspension, it is important to administer the medication as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, consult your healthcare professional for guidance, as they may advise adjusting the dosage or provide specific instructions for your situation.

To administer Cloxacillin 125MG Syrup/Suspension, shake the bottle vigorously, measure the prescribed dose with a marked measuring cup or oral syringe, and administer it orally once or twice a day as directed by your healthcare provider, ensuring it is taken consistently either with or without food.

Following are the conditions when Cloxacillin 125MG Syrup/Suspension should not be used:

• Do not use if the patient is allergic to penicillin antibiotics or any ingredients in the medication.
• Avoid in patients with a history of severe allergic reactions to other beta-lactam antibiotics (such as cephalosporins).
• Not recommended for individuals with a history of liver problems or jaundice caused by Cloxacillin.
• Do not administer to patients with mononucleosis or lymphatic leukemia.
• Should not be used if the patient has kidney disease or impairment.
• Contraindicated in patients with a history of gastrointestinal problems, especially colitis.
• Avoid use if the patient has a history of severe or persistent diarrhea.

The side effects of Cloxacillin 125MG Syrup/Suspension may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Skin rashes or itching
• Allergic reactions (hives, swelling, difficulty breathing)
• Vaginal itching or discharge
• Yeast infections
• Changes in liver function tests

Following are the precautions and warnings for Cloxacillin 125MG Syrup/Suspension:

• Do not use if you are allergic to Cloxacillin or any penicillin-type medications. Seek immediate medical attention if you experience signs of an allergic reaction.
• Inform your doctor if you have a history of kidney or liver disease, as dose adjustments may be necessary.
• Prolonged use may lead to the overgrowth of non-susceptible bacteria or fungi. Regularly monitor for signs of superinfection.
• Cloxacillin may cause diarrhea, which can be a sign of a new infection. Consult your doctor if diarrhea becomes severe or persistent.
• This medication should be used with caution in newborns and premature infants, especially those with jaundice or low birth weight.
• Elderly patients may be more susceptible to adverse effects; close monitoring is recommended.
• If you have a history of gastrointestinal diseases, especially colitis, inform your doctor as Cloxacillin may exacerbate these conditions.

Following are the drug interactions for Cloxacillin 125MG Syrup/Suspension:

• Probenecid can increase the blood levels of Cloxacillin, potentially enhancing its side effects.
• Concurrent use with methotrexate may increase the risk of methotrexate toxicity.
• Cloxacillin may reduce the effectiveness of oral contraceptives, leading to breakthrough bleeding and potential contraceptive failure.
• Anticoagulants like warfarin may have their effects altered, requiring close monitoring of coagulation parameters.
• Nephrotoxic drugs, such as aminoglycosides, when combined with Cloxacillin, may increase the risk of kidney damage.
• The effectiveness of live attenuated vaccines may be reduced during and shortly after Cloxacillin treatment.
• Cloxacillin may interact with other antibiotics, such as cephalosporins, potentially affecting therapeutic outcomes.

Following are the food interactions for Cloxacillin 125MG Syrup/Suspension:

• Avoid consuming alcohol during the treatment period as it may increase the risk of liver-related side effects and can also reduce the effectiveness of the medication.
• Consuming high-fat meals may slightly delay the absorption of Cloxacillin, but it does not significantly impact its overall effectiveness.
• Grapefruit and grapefruit juice should be consumed with caution as they may interfere with the metabolism of some medications, although the interaction with Cloxacillin is not well-established.
• Avoid excessive consumption of dairy products, as Cloxacillin may reduce the absorption of calcium, leading to potential nutritional deficiencies.
• Ensure an adequate fluid intake to maintain hydration, especially if the medication causes gastrointestinal side effects like nausea or vomiting.
• There are no specific food restrictions, but maintaining a balanced diet is advisable to support overall health during the treatment process.
• Consult your healthcare provider for personalized advice on diet and nutrition while taking Cloxacillin, especially if you have any specific dietary concerns or medical conditions.

Cloxacillin 125MG Syrup/Suspension should be stored with caution to ensure its effectiveness and safety. Keep the medication in a cool and dry place, preferably at room temperature, and away from direct exposure to sunlight or moisture. It is crucial to store it in its original container, tightly sealed, to maintain its integrity and prevent contamination. Avoid placing it in the bathroom or near heat sources like radiators or ovens, as temperature fluctuations can impact the medicine's potency. Dispose of any unused or expired syrup responsibly; do not flush it or pour it down the drain. Consult your pharmacist for guidance on proper disposal methods to protect the environment. Always keep medications out of children's reach to prevent accidental consumption.

Following are the quick tips for Cloxacillin 125MG Syrup/Suspension:

• Always follow the dosage instructions provided by your doctor or pharmacist.
• Administer the prescribed amount using an accurate measuring device.
• Ensure the medication is well-mixed by shaking the bottle thoroughly before each use.
• Cloxacillin can be taken with or without food, but a full glass of water is recommended.
• Avoid missing doses; if you miss one, take it as soon as you remember, unless it's almost time for the next dose.
• Do not double the dose to make up for a missed one; stick to the prescribed schedule.
• Store the syrup at room temperature, away from direct sunlight and moisture.