Orinase-Met (2/500mg) 30 Tablets

Glimepiride is a medication that helps to lower blood sugar levels in people with type 2 diabetes by increasing the body's sensitivity to insulin and indirect release of insulin from pancreatic cells. Insulin is a natural hormone that helps to regulate blood sugar levels. Metformin is a drug that is widely used to treat diabetes, helping to reduce glucose production in the liver, decrease glucose absorption from the intestines, and enhance glucose uptake by muscles. It is considered a biguanide drug, which is a class of drugs that helps to reduce glucose levels. When Glimepiride and Metformin are used together, they work synergistically to achieve better glycemic control and help manage blood sugar levels in patients with type 2 diabetes, thereby reducing the risk of developing complications from high blood sugar.

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Biguanide, Sulfonylurea

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Tablet

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Unveiling its multifaceted uses and transformative applications as follows:

• Treatment of type 2 diabetes mellitus
• Stimulates the pancreas to produce more insulin
• Reduces the amount of glucose absorbed in the body
• Reduces the liver's glucose production.

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Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Take 2mg tablet of Glimepiride with breakfast or the first meal of the day.
• Take Glimepiride alone, at least 10 minutes before or after a meal.
• Adjust the Glimepiride dose based on blood glucose levels and glycemic control. But, do not take more than 16mg daily.
• Start with a usual dose of Metformin Hydrochloride is 500mg once or twice daily with meals.
• Maximum dose of Metformin Hydrochloride is 2500mg daily. Divide the total daily dose into smaller doses to be taken with each meal.

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An overdose of glimepiride and metformin hydrochloride can be considered a medical emergency and should be addressed promptly. If you recognize these symptoms, it is important to seek local emergency services or visit the nearest emergency room. The symptoms of a glimepiride overdose may include symptoms such as low blood sugar, which in turn can cause symptoms such as dizziness, drowsiness, sweating, tremors, and confusion. In treating a glimepiride overdose, medical staff will typically look to restore blood sugar levels by administering glucose or sugary drinks, while also monitoring for any further complications. On the other hand, a metformin hydrochloride overdose can cause lactic acidosis. This condition can display symptoms such as abdominal discomfort, weakness, muscle pain, shortness of breath, and a sudden feeling of severe dizziness or lightheadedness. Treatments for this overdose consist of immediate medical care, with monitoring of oxygen levels, blood sugar, and lactate levels, and may require emergency dialysis or other interventions.

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It is important to take your medication as soon as possible if you miss a dose, to ensure its effectiveness. However, if you are close to your next scheduled dose, it is recommended to skip the missed dose and return to your regular schedule. If you have any worries or concerns about missing a dose, contact your physician or healthcare provider for assistance and guidance.

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Before taking Glimepiride 2mg and Metformin Hydrochloride 500mg, it is important to understand the directions and precautions that come with the medication. For Glimepiride, it is essential to take the medication orally, usually once or twice a day, depending on the direction of your doctor. You can take it with or without food. Taking plenty of water while taking the medication is necessary to avoid dehydration and kidney problems. The dosage is based on your medical condition, your age, your response to treatment, and other medications you are currently taking. It is necessary to inform your doctor and pharmacist about all the products you use, including prescription drugs, nonprescription drugs, and herbal products. To achieve the desired effect, you must take the Glimepiride regularly and continuously as per the prescription. If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and follow the regular dosing schedule. Do not double up to catch up.For Metformin Hydrochloride, the procedure is similar. The medication is taken orally, usually once or twice a day, with or without food. The dosage is in correlation with your medical condition, age, response to treatment, and other medications you take. It is important to take this medication regularly as prescribed to benefit from it. If you experience stomach issues such as nausea, upset stomach, or vomiting, take the medication with food or milk, as stated in the instructions. It is crucial to avoid alcohol consumption as it can increase the risk of developing low blood sugar or kidney problems. These medications should be taken as directed and with utmost care. It is important to consult your doctor or pharmacist if you have any questions or concerns regarding the use of these medications.

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Discerning instances where this medication may not be appropriate:

• Hypoglycemia (low blood sugar)
• Kidney disorders
• Pancreatitis
• Gastrointestinal disorders
• Surgery
• Alcohol consumption
• Pregnancy and breastfeeding
• Hypersensitivity

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Unraveling the side effects lurking behind this medications are as follows:

• Hypoglycemia (low blood sugar)
• Dizziness
• Headache
• Nausea
• Upset stomach
• Diarrhea
• Skin rash
• Allergic reactions (e.g., itching, swelling, severe dizziness, difficulty breathing)
• Liver problems (symptoms may include yellowing of the eyes/skin, dark urine, persistent nausea/vomiting)
• Blood disorders (symptoms may include easy bruising/bleeding)
• Photosensitivity (increased sensitivity to sunlight)
• Changes in taste
• Weight gain
• Edema (swelling)
• Unusual tiredness or weakness
• Vision changes
• Gastrointestinal issues
• Loss of appetite
• Metal taste in the mouth
• Headache
• Muscle pain or weakness
• Difficulty breathing or shortness of breath
• Rapid or irregular heart rate
• Lactic acidosis (rare but serious; symptoms may include weakness, trouble breathing, unusual muscle pain, stomach discomfort, and feeling cold)
• Hypoglycemia (low blood sugar) when used in combination with other diabetes medications
• Skin reactions such as rash or itching
• Vitamin B12 deficiency over time
• Liver problems (uncommon)
• Kidney problems (rare)
• Elevated levels of lactic acid in the blood (lactic acidosis) in severe cases

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Here are the crucial warnings and precautions for glimepiride:

• Avoid use during lactation.
• Adjust dosage if risk factors for hypoglycemia are present and monitor closely for severe hypoglycemia.
• Temporary use of insulin may be required in exceptional stress situations such as trauma, surgery, or infection with fever.
• Regularly check blood and urine glucose levels as well as glycated hemoglobin (HbA1c) levels.
• Be cautious, as this medication may impair the ability to drive or operate machinery.
• Monitor for signs of hypoglycemia, especially when used in conjunction with other antidiabetic medications or alcohol.
• Educate patients about the symptoms of hypoglycemia and the importance of maintaining a regular meal schedule.
• Discontinue use if allergic reactions or severe side effects occur and consult a healthcare provider.

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Drug interactions with metformin and glimepiride include:

• Insulin (may increase risk of hypoglycemia)
• Renal impairment (may require dose adjustments)
• Diuretics (e.g., furosemide) (may increase risk of hypoglycemia or dehydration)
• Beta-blockers (e.g., propranolol) (may mask symptoms of hypoglycemia)
• CYP2C9 inhibitors (e.g., fluconazole) (may increase glimepiride levels)
• CYP2C9 inducers (e.g., rifampin) (may decrease glimepiride levels)
• NSAIDs (e.g., ibuprofen) (may increase risk of renal impairment)
• Alcohol (may enhance hypoglycemic effects)
• Metformin and glimepiride generally have minimal interaction with other medications, but individual patient scenarios should always be reviewed for potential interactions.

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Storing Glimepiride 2mg and Metformin Hydrochloride 500mg requires following the manufacturer's instructions to ensure the safety and effectiveness of the medication. These should be stored at room temperature, away from heat and light, in a cool and dry place like a cupboard or drawer. Ensure that these medications are out of reach of children or pets, as they are dangerous for anyone other than the intended patient. It is important to check the specific medication's label for any storage instructions as well as precautions and warnings. If you have any questions or concerns about storing these medications, it is vital to consult with your healthcare provider or pharmacist.

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