ORIVER 20MG TAB

ORIVER 20MG TAB

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  • Manufacturer TABROS PHARMACEUTICALS (PVT.) LTD.
  • Generic Name

    Isotretinoin 20mg

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4.9/ 5
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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Isotretinoin, a derivative of vitamin A, primarily exerts its therapeutic effects by influencing cellular differentiation and proliferation. It binds to specific nuclear receptors called retinoic acid receptors (RARs), which are present in various tissues, including the skin. Upon binding, isotretinoin regulates gene expression by acting as a transcriptional regulator. One of its key actions is reducing the activity of sebaceous glands, leading to decreased sebum production. This is achieved by inhibiting the cellular proliferation of sebaceous gland cells and promoting their differentiation. Additionally, isotretinoin can modulate keratinocyte proliferation and differentiation, contributing to the normalization of epidermal turnover. These mechanisms collectively contribute to the improvement of acne lesions and the overall reduction of acne severity.

  • Ingredients

    Isotretinoin 20mg

  • Drug Class

    Retinoid

  • Dosage Form

    Tablet

  • Uses

    The following are the uses of Isotretinoin 20mg Tablet:

    • Used for treating severe acne that is resistant to other treatments.
    • Used to achieve long-term remission of acne symptoms.
    • Used to reduce the size and output of sebaceous glands, controlling oil production.
    • Used to prevent scarring and psychological impact associated with severe acne.
    • Used in cases where acne has not responded to oral antibiotics and topical treatments.
    • Used under strict medical supervision due to potential side effects.
    • Used as part of a comprehensive acne treatment plan, often combined with other therapies.
  • In case of Overdose

    In the case of an overdose of Isotretinoin 20mg Tablets, it is important to seek medical advice promptly. Symptoms of an overdose may include severe headache, blurred vision, dizziness, and skin reactions. If you suspect an overdose, contact a healthcare professional or a poison control center for guidance. Quick action can help mitigate potential health risks associated with excessive consumption of this medication. It is crucial to keep this medication out of reach of children to prevent accidental ingestion.

  • Missed Dose

    In the case of a missed dose of Isotretinoin 20mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely adjust your dosage and get back on track with your treatment plan. It is recommended to set reminders or use a pill organizer to help you remember to take your medication on time.

  • How To Use

    To take Isotretinoin 20mg Tablets, swallow the tablet whole with a full glass of water, preferably during a meal or as directed by your healthcare professional, ensuring you follow the prescribed dosage and duration as instructed.

  • When Not to Use

    Here are the circumstances when Isotretinoin 20mg Tablet should not be prescribed:

    • Strictly avoid if you are pregnant or planning to become pregnant. Isotretinoin can cause severe birth defects.
    • Do not take if you are breastfeeding as the drug may pass into breast milk and harm the nursing infant.
    • Individuals with a known allergy or sensitivity to Isotretinoin or any of its excipients should not use this medication.
    • Not suitable for patients with severe liver or kidney disease, as it can worsen these conditions.
    • Avoid if you have uncontrolled or active inflammation of the bowel (such as Crohn's disease or ulcerative colitis).
    • Isotretinoin is contraindicated in patients with severely elevated lipid levels in the blood (hyperlipidemia).
    • Do not use if you have a history of severe depression or psychiatric disorders, as it may exacerbate these conditions.
    • Not recommended for individuals with a history of osteoporosis or other bone disorders.
  • Side Effects

    The side effects of Isotretinoin 20mg Tablet may include:

    • Dryness of the skin, lips, and nose
    • Skin peeling and itching
    • Nosebleeds
    • Joint and muscle pain
    • Headaches
    • Changes in vision (including night blindness)
    • Increased sensitivity to sunlight
    • Mood changes and depression
  • Precautions & Warnings

    Following are the precautions and warnings for Isotretinoin 20mg Tablet:

    • Not recommended for pregnant women due to its potential to cause severe birth defects.
    • Women of childbearing age should use effective contraception while on this medication and for at least one month after stopping treatment.
    • Regular blood tests are required to monitor liver function and lipid levels.
    • Avoid excessive exposure to sunlight and UV rays; use sunscreen and protective clothing.
    • Discontinue use if experiencing mood changes, depression, or suicidal thoughts.
    • Do not donate blood while on this medication and for at least one month after stopping treatment.
    • May cause vision changes; avoid driving or operating machinery if vision is affected.
  • Drug Interactions

    Following are the drug interactions for Isotretinoin 20mg Tablet:

    • Avoid with tetracyclines, as it may increase intracranial pressure.
    • Concomitant use with vitamin A increases the risk of hypervitaminosis A.
    • Interactions with oral contraceptives may reduce their effectiveness, requiring alternative methods.
    • Isotretinoin may elevate blood levels of certain antipsychotics and antidepressants, increasing side effects.
    • Use with St. John's Wort may reduce Isotretinoin's effectiveness.
    • Alcohol consumption can increase the risk of liver toxicity and pancreatitis.
    • Caution with concurrent use of certain medications metabolized by the liver, as it may alter Isotretinoin's effects.
  • Food Interactions

    Following are the food interactions for Isotretinoin 20mg Tablet:

    • Vitamin A-rich foods like liver, fish liver oil, and supplements should be avoided as they can increase the risk of vitamin A toxicity when combined with Isotretinoin.
    • Dairy products and high-fat meals can decrease the absorption of Isotretinoin, so it is best to separate them by a few hours.
    • Grapefruit and grapefruit juice should be avoided as they can increase the levels of Isotretinoin in the blood, leading to potential toxicity.
    • Alcohol may increase the risk of liver damage and other side effects, hence, should be consumed in moderation or avoided.
    • Avoid excessive Vitamin E intake from supplements or high-dose foods like nuts and seeds, as it can interfere with Isotretinoin's action.
    • Avoid high-sugar diets as they can increase skin inflammation and worsen acne symptoms.
    • Ensure a balanced diet rich in antioxidants, omega-3 fatty acids, and lean proteins to support skin health during treatment.
  • Storage/Disposal

    Isotretinoin 20mg Tablets should be stored in a secure and dry location, away from direct sunlight, moisture, and heat sources. Maintain the tablets in their original packaging, ensuring the container is tightly sealed to prevent contamination. It is crucial to keep the medication out of children's reach to avoid accidental ingestion. Regularly check the expiration date, and do not use the tablets beyond this date. When disposing of unused or expired tablets, do not flush them or pour them down the drain. Instead, consult your pharmacist or local waste management guidelines for safe disposal practices to protect the environment and public health. Proper storage and disposal of Isotretinoin Tablets are essential to maintain their effectiveness and prevent any potential harm.

  • Quick Tips, if any

    Following are the quick tips for Isotretinoin 20mg Tablet:

    • Consult a dermatologist before starting this medication.
    • Inform your doctor about medical history and current medications.
    • Take the tablet with food to enhance absorption and reduce side effects.
    • Avoid donating blood while on this medication and for 1 month after stopping.
    • Do not share this medication with others, even with similar symptoms.
    • Store in a cool, dry place, away from sunlight and moisture.
    • Follow up with your doctor regularly to monitor progress and adjust dosage.

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