ORNIX 4MG TAB

ORNIX 4MG TAB

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  • Manufacturer MARTIN DOW PHARMACEUTICALS (PVT.) LTD.
  • Generic Name Rosiglitazone

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Rosiglitazone 4MG Tablet primarily acts as an insulin sensitizer, belonging to the thiazolidinedione class of drugs. Its mechanism of action involves selectively binding to peroxisome proliferator-activated receptor-gamma (PPAR-gamma) found in adipose tissue, skeletal muscle, and liver cells. Upon activation, PPAR-gamma forms a heterodimer with another nuclear receptor, leading to the regulation of various genes involved in glucose and lipid metabolism. This results in enhanced insulin sensitivity, particularly in muscle and adipose tissue, where it improves glucose uptake and utilization. Additionally, rosiglitazone inhibits the production of glucose in the liver, further contributing to better blood sugar control. By modulating these metabolic pathways, the drug helps manage insulin resistance and related conditions.

  • Ingredients

    Rosiglitazone
  • Drug Class

    Thiazolidinedione.

  • Dosage Form

    Tablet

  • Uses

    The following are the uses of Rosiglitazone 4MG Tablet:

    • Used for treating type 2 diabetes when diet and exercise alone are not effective in controlling blood sugar levels.
    • Used to improve insulin sensitivity, helping the body use insulin more efficiently.
    • Used to reduce insulin resistance, allowing the body's own insulin to work better.
    • Used for lowering blood glucose levels by enhancing the action of insulin in muscles and fatty tissues.
    • Used for managing blood sugar fluctuations, especially in patients with poor glycemic control.
    • Used to prevent long-term complications associated with diabetes, such as cardiovascular issues.
    • Used in combination with other diabetes medications for comprehensive blood sugar management.
  • In case of Overdose

    In the case of an overdose of Rosiglitazone 4MG Tablets, it is important to recognize the potential risks. Symptoms may include hypoglycemia, especially in patients with insulin or insulin secretagogues. Other signs of overdose can include nausea, chest pain, palpitations, and sweating. Immediate medical intervention is advised, and healthcare professionals should be contacted for guidance on managing the specific effects of an overdose. Prompt action can help mitigate potential complications.

  • Missed Dose

    In the case of a missed dose of Rosiglitazone 4MG Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you miss multiple doses, consult your healthcare provider for guidance on how to adjust your dosage and get back on track with your treatment plan. It is essential to maintain consistency in taking this medication as prescribed.

  • How To Use

    To take Rosiglitazone 4MG Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

  • When Not to Use

    Following are the conditions when Rosiglitazone 4MG Tablet should not be taken:

    • Avoid if allergic to Rosiglitazone or any similar medications.
    • Not suitable for patients with heart failure or a history of heart-related problems.
    • Should not be used in individuals with active liver disease or elevated liver enzymes.
    • Contraindicated in patients with type 1 diabetes mellitus.
    • Not recommended for those with a history of stroke or transient ischemic attack (TIA).
    • Avoid if you have fluid retention problems or edema.
    • Do not use if you have a history of bone fractures or osteoporosis.
    • Not suitable for individuals with severe anemia.
    • Should not be used if you have bladder cancer or a history of bladder tumors.
  • Side Effects

    The side effects of Rosiglitazone 4MG Tablet may include:

    • Weight gain
    • Fluid retention (edema)
    • Headache
    • Back pain
    • Upper respiratory tract infection
    • Sinusitis
    • Muscle pain
    • Hypoglycemia (low blood sugar)
  • Precautions & Warnings

    Following are the precautions and warnings for Rosiglitazone 4MG Tablet:

    • Not recommended for patients with heart failure or a history of heart disease; it may worsen these conditions.
    • Patients with liver problems should exercise caution as this medication can affect liver function. Regular monitoring is essential.
    • Blood sugar levels should be monitored regularly, especially in diabetic patients, as Rosiglitazone can cause hypoglycemia or hyperglycemia.
    • Not suitable for individuals with a history of fluid retention or edema, as it may lead to fluid build-up.
    • Patients with anemia or low red blood cell count should be closely monitored as this drug may worsen these conditions.
    • May cause weight gain; regular weight monitoring is advised.
    • Not recommended for pregnant or breastfeeding women due to potential risks to the fetus or infant.
    • Should be used with caution in the elderly, as they may be more susceptible to the side effects of this medication.
  • Drug Interactions

    Following are the drug interactions for Rosiglitazone 4MG Tablet:

    • Concomitant use with insulin or other antidiabetic medications may require adjustment of doses to prevent hypoglycemia or improve glycemic control.
    • Rosiglitazone may enhance the effects of sulfonylureas, increasing the risk of hypoglycemia. Regular monitoring of blood glucose is necessary.
    • Gemfibrozil can increase the exposure of rosiglitazone, potentially leading to fluid retention and heart-related issues.
    • The risk of heart failure may be elevated when used with insulin or other antidiabetic drugs that cause fluid retention.
    • CYP2C8 inhibitors like gemfibrozil can increase rosiglitazone levels, requiring dose adjustments.
    • CYP2C8 inducers (e.g., rifampin) may decrease rosiglitazone's effectiveness, necessitating monitoring and dose adjustments.
    • The risk of edema and heart failure is increased when combined with other medications that cause fluid retention, such as certain blood pressure medications.
  • Food Interactions

    Following are the food interactions for Rosiglitazone 4MG Tablet:

    • Grapefruit and grapefruit juice consumption should be avoided as they may interfere with the metabolism of Rosiglitazone, potentially increasing its blood levels and the risk of side effects.
    • Alcohol intake should be limited or avoided. Alcohol can increase the risk of liver-related side effects and may also reduce the effectiveness of the medication.
    • High-fat meals might delay the absorption of Rosiglitazone, leading to a potential decrease in its peak concentration. It is advisable to take the medication consistently with regard to meal times.
    • A balanced diet with a focus on whole grains, fruits, vegetables, and lean proteins can help manage diabetes effectively when taking Rosiglitazone.
    • Avoid excessive salt intake as Rosiglitazone may cause fluid retention, and high salt consumption can exacerbate this.
    • Caffeine intake should be monitored as it may influence blood sugar levels, and when combined with Rosiglitazone, it might require adjustments in medication dosage.
    • Always discuss any dietary changes or concerns with your healthcare provider to ensure the best management of your condition while taking Rosiglitazone.
    • No specific food restrictions are necessary with Rosiglitazone, but maintaining a healthy diet is essential for optimal management of diabetes.
  • Storage/Disposal

    Rosiglitazone 4MG Tablets should be stored in a cool, dry area, ideally between 68°F and 77°F (20°C and 25°C), with brief excursions permitted between 59°F and 86°F (15°C and 30°C). Keep this medication away from light, excess heat, and moisture (not in the bathroom). It is crucial to store Rosiglitazone in its original container, tightly sealed, to maintain its integrity and prevent contamination. Always check the expiration date before using the medication, and dispose of any unused or expired tablets through proper medical waste disposal channels. Do not flush the medication or throw it into the trash, as it may pose environmental risks. Keep this medication safely locked away from children and pets to prevent accidental ingestion.

  • Quick Tips, if any

    Following are the quick tips for Rosiglitazone 4MG Tablet:

    • Consult your doctor before starting this medication, especially if you have heart-related issues.
    • Take the tablet as directed by your doctor; do not change the dosage without medical advice.
    • Swallow the tablet whole with a full glass of water; do not crush or chew it.
    • Take the medicine at the same time each day to maintain a consistent routine.
    • Do not skip doses; if you miss a dose, take it as soon as you remember, unless it's close to your next dose.
    • Inform your doctor about all the medications you are currently taking to avoid drug interactions.
    • Regularly monitor your blood sugar levels and report any unusual changes to your doctor.

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