OSIVA TAB (20S)

L-Methylfolate, Methylcobalamin, and N-acetylcysteine work synergistically in this tablet formulation. L-Methylfolate is the biologically active form of folate, which serves as a methyl donor, supporting the synthesis of neurotransmitters and DNA methylation. Methylcobalamin, an active vitamin B12 form, also contributes to methylation processes and plays a role in nerve function and homocysteine metabolism. N-acetylcysteine (NAC) acts as a precursor to glutathione, a potent antioxidant, helping to reduce oxidative stress and support cellular health. Together, these components enhance neurotransmitter production, promote neural health, and provide antioxidant defense, potentially benefiting various neurological and psychiatric conditions.

L-Methylfolate, Methylcobalamin, N-acetylcysteine

Vitamins, Amino Acid.

Tablet

The following are the uses of L-Methylfolate, Methylcobalamin, N-acetylcysteine Tablet:

• Used for treating vitamin B12 deficiency and supporting healthy nerve function.
• Used to address folate deficiency, especially in cases where absorption is impaired.
• Effective in supporting liver health and detoxification processes.
• Helps reduce oxidative stress and enhances antioxidant defenses.
• Used for improving cognitive function and mental well-being.
• Supports red blood cell production and prevents anemia.
• Contributes to overall cardiovascular health and homocysteine management.
• Used for promoting healthy skin and hair, as it supports cell growth and repair.

In the case of an overdose of L-Methylfolate, Methylcobalamin, and N-acetylcysteine Tablet, individuals may experience symptoms such as nausea, vomiting, diarrhea, and abdominal pain. Promptly seeking medical assistance is vital, as the healthcare provider can offer appropriate guidance and treatment. Depending on the severity of the overdose, medical professionals may recommend supportive care, monitoring of vital signs, and symptomatic treatment to manage any adverse effects.

In the case of a missed dose of L-Methylfolate, Methylcobalamin, and N-acetylcysteine Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen.

To take the L-Methylfolate, Methylcobalamin, and N-acetylcysteine Tablet, swallow the tablet whole with a glass of water, preferably in the morning or as directed by your healthcare professional. It is recommended to take this tablet on an empty stomach, at least 30 minutes before a meal, to enhance absorption.

Here are the conditions and situations when L-Methylfolate, Methylcobalamin, and N-acetylcysteine Tablet should not be taken:

• Do not take if you have a known allergy or hypersensitivity to any of the active ingredients, L-Methylfolate, Methylcobalamin, or N-acetylcysteine, or any of the tablet's excipients.
• Contraindicated in individuals with a history of pernicious anemia, as it may mask the symptoms of vitamin B12 deficiency.
• Should not be used in patients with untreated or uncontrolled hypertension.
• Avoid if you have a history of psychiatric disorders or are currently experiencing severe psychiatric symptoms.
• Not recommended for individuals with active liver disease or impaired liver function.
• Do not take if you have a history of epilepsy or seizures, as it may lower the seizure threshold.
• Avoid in patients with renal impairment or kidney disease.
• Contraindicated in individuals with active cancer or a history of cancer, especially those receiving chemotherapy or radiation therapy.
• Should not be used in patients with a history of stroke or transient ischemic attack (TIA).
• Not suitable for individuals with a history of cardiovascular disease, such as heart attack or coronary artery disease.

The side effects of L-Methylfolate, Methylcobalamin, and N-acetylcysteine Tablet may include:

• Nausea and vomiting
• Diarrhea or constipation
• Abdominal pain
• Headaches
• Dizziness or lightheadedness
• Skin reactions such as rashes or itching
• Difficulty sleeping (insomnia)
• Mood changes, including anxiety or irritability

Following are the precautions and warnings for L-Methylfolate, Methylcobalamin, and N-acetylcysteine Tablet:

• This medication should be used with caution in patients with a history of allergies or sensitivity to any of its components.
• Patients with a history of neurological disorders or psychiatric illnesses should be monitored closely, as Methylcobalamin may affect their condition.
• L-Methylfolate may interact with certain medications, including anticonvulsants and methotrexate, so dosage adjustments may be required.
• N-acetylcysteine can cause gastrointestinal upset, including nausea and vomiting, so it should be taken with food to minimize these effects.
• Patients with a history of asthma should be cautious as N-acetylcysteine may trigger bronchospasm.
• Do not exceed the recommended dosage, as high doses of Methylcobalamin may lead to skin and nerve issues.
• Consult a healthcare professional before use if you are pregnant, breastfeeding, or planning to become pregnant.
• Keep this medication out of reach of children and pets.

Following are the drug interactions for L-Methylfolate, Methylcobalamin, and N-acetylcysteine Tablet:

• Co-administration with drugs that lower homocysteine levels, such as betaine, may result in additive effects and require dosage adjustments.
• L-Methylfolate may interact with medications used for cancer chemotherapy, potentially reducing their effectiveness.
• Methylcobalamin can interact with chloramphenicol, an antibiotic, decreasing its absorption and effectiveness.
• N-acetylcysteine (NAC) may decrease the effectiveness of nitroglycerin, a medication used for angina.
• Antioxidant properties of NAC can interfere with the activity of chemotherapy drugs and radiation therapy.
• May reduce the effectiveness of activated charcoal used for poisoning treatment.
• Consult a healthcare professional before combining with alcohol, as it may impact the metabolism of L-Methylfolate and NAC.

Following are the food interactions for L-Methylfolate, Methylcobalamin, and N-acetylcysteine Tablet:

• Avoid excessive consumption of foods rich in Vitamin C during treatment, as it can interfere with the absorption of L-Methylfolate.
• Limit the intake of high-protein foods, as they may impact the absorption of Methylcobalamin.
• Grapefruit and its juice should be avoided as they can affect the metabolism of N-acetylcysteine, potentially leading to increased levels in the body.
• Alcohol consumption should be minimized as it can deplete essential vitamins and interfere with the effectiveness of the medication.
• Avoid consuming foods with high levels of nitrates, such as processed meats, as they can interact with N-acetylcysteine.
• Maintain a balanced diet rich in B vitamins to support the overall therapeutic effect of the medication.
• Certain dairy products may reduce the absorption of this medication, so consider spacing out calcium-rich food intake from medication timing.

Store L-Methylfolate, Methylcobalamin, N-acetylcysteine Tablets in a secure location, away from direct sunlight, moisture, and heat. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. Ensure the medication is stored at room temperature, avoiding temperature fluctuations. Regularly check the expiration date, and dispose of any expired or unused tablets responsibly; do not flush them or pour them down the drain. Instead, consult a pharmacist for guidance on safe disposal methods. It is crucial to keep the medication out of children's reach to prevent accidental consumption. Proper storage and disposal practices are essential for maintaining the effectiveness and safety of this medication.

Following are the quick tips for L-Methylfolate, Methylcobalamin, and N-acetylcysteine Tablet:

• Consult your healthcare provider for the correct dosage and duration of treatment.
• Swallow the tablet whole; do not crush or chew for optimal absorption.
• Maintain a consistent schedule by taking the tablet at the same time daily.
• Take the tablet on an empty stomach for better absorption, unless advised otherwise.
• Stay well-hydrated while taking these medications.
• Do not share your medication with others, even if they have similar symptoms.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.