OSIX D SYP

Vitamin D3, also known as cholecalciferol, primarily supports bone health by enhancing calcium and phosphorus absorption in the intestines. It does this by binding to the vitamin D receptor in the gut, promoting the synthesis of calcium-binding proteins and increasing the efficiency of calcium and phosphorus uptake. Additionally, Vitamin D3 regulates calcium and phosphorus levels in the body, contributing to proper bone mineralization. On the other hand, Vitamin K, specifically as Vitamin K1 (phylloquinone) or Vitamin K2 (menaquinone), plays a crucial role in blood clotting and bone metabolism. Vitamin K acts as a cofactor for the enzyme gamma-glutamyl carboxylase, which is responsible for converting glutamate residues into gamma-carboxyglutamate (Gla) residues in certain proteins, particularly those involved in blood coagulation and bone health. This carboxylation process is essential for the proper functioning of these proteins, ensuring effective blood clotting and supporting calcium binding in bones, thereby contributing to bone strength and integrity.

Vitamins.

Suspension

The following are the uses of Vitamin D3, Vitamin K Syrup/Suspension:

• Used for improving bone and teeth health, especially in calcium absorption.
• Used for supporting immune function and reducing the risk of respiratory infections.
• Used for promoting cardiovascular health by regulating blood pressure and calcium levels.
• Used for maintaining brain health, cognitive function, and mood regulation.
• Used for enhancing muscle strength and physical performance, particularly in older adults.
• Used for supporting respiratory health and managing conditions like asthma.
• Used for skin health, including potential benefits for psoriasis and wound healing.
• Used for overall well-being and maintaining the balance of essential nutrients in the body.

In the case of an overdose of Vitamin D3 and Vitamin K Syrup/Suspension, symptoms may include nausea, vomiting, diarrhea, and in severe cases, kidney damage. Excessive Vitamin D3 can lead to hypercalcemia, causing weakness, confusion, and irregular heart rhythms. Vitamin K overdose is rare but may result in bruising or bleeding due to reduced blood clotting ability. Immediate medical intervention is necessary, including gastric lavage and supportive care, to manage symptoms and prevent potential complications.

In the case of a missed dose of Vitamin D3, it is generally recommended to take the missed dose as soon as you remember, but if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. For Vitamin K Syrup/Suspension, if a dose is missed, administer it as soon as possible on the same day. If the entire day's dose is missed, you can either give the missed dose the next day or skip it and continue with the regular schedule, ensuring that you do not double the dose to catch up.

To administer Vitamin D3 and Vitamin K syrup/suspension, measure the prescribed dose using the provided measuring cup or oral syringe, then take it orally once daily, preferably with a meal, following the dosage instructions provided by your healthcare professional.

Following are the conditions/situations when Vitamin D3, Vitamin K Syrup/Suspension should not be used:

• Allergy or hypersensitivity to Vitamin D3 (cholecalciferol) or Vitamin K (phytonadione) or any other ingredients in the syrup/suspension.
• Patients with hypervitaminosis D, a condition where there is an excessive amount of vitamin D in the body.
• Individuals with hypervitaminosis K, a rare condition caused by an overdose of vitamin K.
• Should not be used in patients with kidney stones or a history of kidney disease, as high doses of Vitamin D can increase calcium levels and potentially worsen kidney problems.
• Contraindicated in patients with a history of vitamin K deficiency bleeding disorders or those taking anticoagulant medications, as Vitamin K can interfere with the effectiveness of these drugs.
• Not suitable for individuals with a history of calcium disorders such as hypercalcemia or hypocalcemia.
• Avoid in patients with sarcoidosis, as it can increase calcium levels and worsen the condition.
• Should not be used in individuals with a history of kidney failure or impaired kidney function.

The side effects of Vitamin D3, Vitamin K Syrup/Suspension may include:

• Nausea and vomiting
• Loss of appetite
• Constipation or diarrhea
• Abdominal pain
• Fatigue and weakness
• Dry mouth or increased thirst
• Skin rashes or itching

Following are the precautions and warnings for Vitamin D3, Vitamin K Syrup/Suspension:

• Avoid using this medication if you are allergic to either Vitamin D3 or Vitamin K, or any other ingredients in the syrup.
• Patients with a history of kidney stones or kidney disease should use this medication with caution, as it may increase the risk of stone formation.
• Monitor calcium levels regularly during long-term use, as excessive Vitamin D can lead to hypercalcemia.
• This medication may cause bruising or bleeding more easily, so be cautious if you have a bleeding disorder or are taking blood-thinning medications.
• If you are pregnant or breastfeeding, consult your doctor before use, as Vitamin K can pass into breast milk.
• Do not exceed the recommended dosage without medical advice, as high doses of Vitamin D can be harmful.
• Keep this medication out of reach of children, as accidental ingestion may lead to serious side effects.

Following are the drug interactions for Vitamin D3, Vitamin K Syrup/Suspension:

• Anticoagulant medications (e.g., warfarin, heparin) may have their effects altered, as Vitamin K plays a role in blood clotting. Close monitoring of INR is necessary.
• Drugs that affect fat absorption, such as orlistat or cholestyramine, can reduce the absorption of fat-soluble vitamins like Vitamin D and Vitamin K.
• Thiazide diuretics can increase calcium levels, and when combined with Vitamin D, may lead to hypercalcemia.
• Vitamin D supplementation may decrease the effectiveness of certain anticonvulsant medications, such as phenytoin or phenobarbital.
• Certain antifungal medications, like ketoconazole, may inhibit Vitamin D metabolism, potentially leading to increased Vitamin D levels.
• Calcium channel blockers, when used with Vitamin D, may enhance the effect of calcium on the heart and blood vessels.
• Bisphosphonates, used for osteoporosis, may have increased efficacy when combined with adequate Vitamin D and Vitamin K levels.

Following are the food interactions for Vitamin D3, Vitamin K Syrup/Suspension:

• Vitamin D3 is best absorbed when consumed with a meal containing healthy fats like avocado, nuts, seeds, olive oil, or fatty fish, as it is a fat-soluble vitamin.
• Fatty fish such as salmon, mackerel, and tuna are excellent sources of Vitamin D3, so consuming them can enhance the effects of the syrup.
• Vitamin K is fat-soluble, so pairing it with healthy fats can improve absorption. Consider avocado, nuts, or olive oil.
• Green leafy vegetables like spinach, kale, and broccoli are rich in Vitamin K, and including them in your diet can support the medication's effectiveness.
• Limit alcohol consumption as it may interfere with Vitamin D absorption and utilization.
• Avoid excessive caffeine intake, as it may hinder Vitamin D absorption and potentially impact bone health.
• Certain mineral oils and cholesterol-lowering medications can interfere with Vitamin D and Vitamin K absorption, so consult your healthcare provider for guidance.

Vitamin D3 and Vitamin K Syrup/Suspension should be stored in a cool, dry area at room temperature, ideally between 68°F and 77°F (20°C and 25°C). Protect the medication from exposure to light and moisture by keeping it in its original packaging, ensuring the container is tightly sealed. Avoid storing it in the bathroom or kitchen, as heat and humidity can degrade the quality of the medication. Dispose of any unused or expired syrup responsibly; do not dispose of it in wastewater or household waste. Contact your pharmacist or healthcare professional for advice on proper disposal methods. Keep this medication away from children to prevent accidental consumption.

Following are the quick tips for Vitamin D3, Vitamin K Syrup/Suspension:

• Consult your healthcare provider for the prescribed dosage and duration of the syrup.
• Give the prescribed dose using the measuring cup or dropper provided.
• Store the syrup at room temperature, away from excessive heat and moisture.
• Ensure the syrup is well-mixed by gently shaking the bottle before each use.
• Administer the syrup directly into the mouth or mix it with a small amount of food or beverage if preferred.
• Do not mix with hot beverages or dairy products as it may affect absorption.
• Regularly monitor Vitamin D and Vitamin K levels as directed by your healthcare provider.
• Keep a record of your/your child's intake to ensure consistent dosing.