OSTENEM 30'S CAPSULE

Vitamin D3, also known as cholecalciferol, primarily enhances calcium absorption in the gut, promoting bone health. It binds to the vitamin D receptor (VDR) in various target cells, influencing gene expression and calcium metabolism. When Vitamin D3 binds to the VDR, it forms a complex that migrates to the nucleus, where it regulates the transcription of genes involved in calcium homeostasis. This process increases the efficiency of calcium absorption from the diet, contributing to optimal bone mineralization. Vitamin K, specifically Vitamin K1 (phylloquinone) and Vitamin K2 (menaquinone), plays a crucial role in blood coagulation and bone metabolism. Vitamin K acts as a cofactor for the enzyme gamma-glutamyl carboxylase, which catalyzes the conversion of glutamic acid residues to gamma-carboxyglutamic acid (Gla) in certain proteins. This carboxylation process is essential for the activation of clotting factors involved in blood coagulation. Additionally, Vitamin K promotes the carboxylation of osteocalcin, a protein crucial for bone mineralization. By facilitating calcium binding to osteocalcin, Vitamin K contributes to the proper formation and maintenance of bone structure.

Vitamins.

Capsule

The following are the uses of Vitamin D3, Vitamin K Capsule:

• Used for bone health, aiding in the absorption of calcium and phosphorus.
• Used for maintaining a healthy immune system and reducing the risk of autoimmune diseases.
• Used for supporting cardiovascular health by regulating blood pressure and reducing inflammation.
• Used for potential cancer prevention, particularly for colorectal and breast cancer.
• Used for brain health and cognitive function, including mood regulation.
• Used for skin health, promoting wound healing and reducing skin inflammation.
• Used for optimizing muscle function and reducing muscle pain.
• Used for overall health and wellness, as it plays a role in various bodily functions.

In the case of an overdose of Vitamin D3 and Vitamin K capsules, symptoms may include nausea, vomiting, loss of appetite, excessive thirst, and frequent urination. Severe cases can lead to bone pain, kidney problems, and even heart rhythm abnormalities. Prompt medical attention is necessary, and treatment may involve managing symptoms and providing supportive care. It is crucial to store these supplements out of reach of children and follow the recommended dosage guidelines to prevent accidental ingestion and potential health risks.

In the case of a missed dose of Vitamin D3, it is generally recommended to take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose. However, if it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. For Vitamin K Capsule, if you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular dosing routine. It is best to consult a healthcare professional if you have any concerns or questions about missed doses.

To take the Vitamin D3 and Vitamin K Capsule, simply swallow the capsule with a glass of water, preferably with a meal, following the dosage instructions provided by your healthcare professional.

Here are the conditions or situations when Vitamin D3 and Vitamin K Capsule should not be used:

• Avoid if you have a known allergy or hypersensitivity to Vitamin D3 (cholecalciferol) or Vitamin K (phylloquinone/menadione).
• Do not take if you have a medical condition that leads to excessive calcium accumulation in the body (hypercalcemia) or excessive urinary excretion of calcium (hypercalciuria).
• Not recommended for individuals with kidney stones or a history of kidney disease.
• Should not be used in patients with impaired kidney function or kidney failure.
• Contraindicated in people with a condition called hypervitaminosis D, where there is an abnormally high level of vitamin D in the body.
• Avoid if you have a blood clotting disorder or are taking anticoagulant medications without medical supervision.
• Not suitable for individuals with a history of heart disease or blood vessel blockages.

The side effects of Vitamin D3 and Vitamin K Capsule may include:

• Nausea and vomiting
• Diarrhea or constipation
• Stomach cramps or pain
• Fatigue and weakness
• Loss of appetite
• Itching or rash
• Allergic reactions (such as hives, swelling, or difficulty breathing)
• Increased risk of bleeding, especially with high doses of Vitamin K.

Following are the precautions and warnings for Vitamin D3, Vitamin K Capsule:

• Individuals with a known allergy to Vitamin D3 or Vitamin K should not use this supplement.
• Those with a history of kidney stones or kidney disease should exercise caution and consult a healthcare provider before use, as Vitamin D and Vitamin K can affect kidney function.
• This supplement may increase the risk of bleeding, especially in individuals taking anticoagulant medications. Monitor for any signs of bleeding and consult a doctor if on blood thinners.
• Vitamin D3 can cause elevated calcium levels in the blood, which can lead to serious health issues. Regular monitoring is advised, especially for those with a history of hypercalcemia.
• Do not exceed the recommended dosage, as high doses of Vitamin D can lead to toxicity, causing symptoms like nausea, vomiting, and kidney problems.
• Pregnant and breastfeeding women should consult their healthcare provider before taking this supplement, as Vitamin D and K can pass into breast milk.
• Keep out of reach of children. Accidental overdose of Vitamin D can be harmful.
• Store in a cool, dry place, away from direct sunlight and moisture.

Following are the drug interactions for Vitamin D3, Vitamin K Capsule:

• Anticoagulant medications (e.g., warfarin) may have their effects altered, requiring close monitoring of coagulation parameters.
• Vitamin K can reduce the effectiveness of oral anticoagulants, potentially leading to blood clotting.
• Vitamin D may interact with certain medications that affect calcium levels, such as thiazide diuretics and calcium channel blockers.
• Caution is advised when taking Vitamin D with aluminum-containing antacids, as it may reduce Vitamin D absorption.
• Certain medications metabolized by the liver may have altered blood levels when taken with Vitamin D, including some anticonvulsants and corticosteroids.
• The absorption of Vitamin K can be reduced by medications such as orlistat and cholestyramine.
• Vitamin K can decrease the effectiveness of certain antibiotics, such as cephalosporins and penicillins.

Following are the food interactions for Vitamin D3 and Vitamin K Capsule:

• Avoid excessive consumption of foods rich in Vitamin K like leafy green vegetables, broccoli, and Brussels sprouts when taking Vitamin K supplements, as it can lead to an imbalance and reduce the effectiveness of the medication.
• Fatty fish such as salmon, mackerel, and tuna, as well as egg yolks and fortified dairy products, can enhance Vitamin D absorption as they are rich in Vitamin D.
• Consuming high-fiber foods like whole grains, legumes, and nuts can slow down the absorption of both Vitamin D3 and Vitamin K, potentially reducing their effectiveness.
• Avoid grapefruit and grapefruit juice as they may interfere with Vitamin D3 metabolism, leading to increased levels of the vitamin in the body.
• Limit alcohol intake as excessive alcohol consumption can impair the liver's ability to activate Vitamin D3 and may also reduce Vitamin K absorption.
• Dairy products like milk, cheese, and yogurt can enhance Vitamin D absorption, as they often contain small amounts of this fat-soluble vitamin.
• Vitamin D3 supplements are best absorbed when taken with a meal containing healthy fats, as they aid in the vitamin's solubility and absorption.
• Certain mineral oils and laxatives can interfere with the absorption of both vitamins, so it is advisable to separate their intake.

Vitamin D3, Vitamin K capsules should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the capsules in their original container, tightly sealed, to maintain their integrity and prevent contamination. Avoid storing them in hot or humid environments like bathrooms or near heat sources, as this can degrade the medication. Dispose of any unused or expired capsules responsibly; do not flush or pour them down the drain. Consult a pharmacist or healthcare professional for guidance on proper disposal methods. Keep the medication away from children to prevent accidental consumption.

Following are the quick tips for Vitamin D3 and Vitamin K Capsules:

• Take the capsule with a meal to enhance absorption, preferably with a fat-containing meal.
• Take the capsule at the same time each day to maintain consistent levels.
• If you have difficulty swallowing capsules, consider opening it and mixing the contents with a soft food or beverage.
• Ensure you are getting sufficient sunlight exposure for natural Vitamin D production.
• Store the capsules in a cool, dry place, away from direct sunlight.
• Do not take more than the recommended dose, as excessive Vitamin D can lead to toxicity.
• Consult your healthcare provider if you are taking other medications to ensure compatibility.