OSTEONIL 60MG TAB

Raloxifene, a medication commonly found in 60mg tablets, operates as a selective estrogen receptor modulator (SERM). Its primary mechanism of action involves binding to estrogen receptors in various tissues, exhibiting both estrogenic and anti-estrogenic effects depending on the target tissue. In bones, raloxifene acts as an estrogen agonist, stimulating bone formation and inhibiting bone resorption, which helps in maintaining bone density and preventing osteoporosis. Conversely, in breast tissue, it acts as an estrogen antagonist, blocking the effects of estrogen and reducing the risk of estrogen-dependent breast cancer. This dual action makes raloxifene a unique treatment option for managing postmenopausal osteoporosis and reducing the risk of invasive breast cancer in high-risk individuals.

Selective estrogen receptor modulator

Tablet

The following are the uses of Raloxifene 60mg Tablet:

• Used for treating and preventing osteoporosis in postmenopausal women.
• Used to reduce the risk of invasive breast cancer in high-risk individuals.
• Used to manage bone pain and reduce the risk of fractures in individuals with Paget's disease of the bone.
• Used to improve bone density and reduce fracture risk in those with low bone mass.
• Used as a preventive measure against osteoporosis for women at high risk.
• Used to promote bone health and reduce bone loss in certain medical conditions.
• Used to support overall bone strength and quality, aiding in fracture prevention.

In the case of an overdose of Raloxifene 60mg Tablets, it is important to recognize the potential symptoms and take appropriate action. Common signs of overdose may include nausea, vomiting, and dizziness. If an overdose is suspected, it is recommended to seek medical advice promptly. Treatment options may involve supportive care and monitoring of vital signs. Prompt action and medical consultation can help manage the situation effectively and ensure the well-being of the individual.

In the case of a missed dose of Raloxifene 60mg Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for advice on how to proceed, as they may provide specific instructions based on your medical history and the reason for prescribing Raloxifene.

To take Raloxifene 60mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, following the instructions provided by your healthcare professional, who will determine the appropriate dosage based on your medical condition.

Here are the conditions and situations when Raloxifene 60mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to Raloxifene or similar medications.
• Contraindicated in women who are pregnant or breastfeeding.
• Not recommended for individuals with a history of blood clots or deep vein thrombosis (DVT).
• Should not be used in patients with active or recent history of stroke or mini-stroke (transient ischemic attack).
• Contraindicated in individuals with untreated or uncontrolled high cholesterol or triglycerides.
• Not suitable for patients with severe kidney disease or those on dialysis.
• Should be avoided if you have a history of surgery for blood clots in the legs or lungs.
• Do not take if you have active or recent breast cancer or are at high risk for developing breast cancer.
• Not recommended for individuals with a history of liver disease or impaired liver function.

The side effects of Raloxifene 60mg Tablet may include:

• Hot flashes
• Leg cramps
• Flu-like symptoms (fever, chills, muscle/joint aches)
• Swelling in the legs or arms
• Rapid or irregular heartbeat
• Increased risk of blood clots (deep vein thrombosis or pulmonary embolism)
• Vaginal bleeding or discharge
• Skin rash or itching

Following are the precautions and warnings for Raloxifene 60mg Tablet:

• Not recommended for individuals with a history of or current blood clots, such as deep vein thrombosis or pulmonary embolism.
• Patients with a history of stroke or mini-stroke should use with caution and under medical supervision.
• May increase the risk of hot flashes, leg cramps, and flu-like symptoms; consult your doctor if these symptoms persist or worsen.
• Regular monitoring of blood lipids and liver function is advised during treatment.
• Women with a history of or at risk for uterine cancer should not use Raloxifene.
• Not intended for use in children and adolescents under 18 years old.
• Raloxifene may cause dizziness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.

Following are the drug interactions for Raloxifene 60mg Tablet:

• Thiazide diuretics may increase the risk of thromboembolic events when used with raloxifene.
• Raloxifene can decrease the absorption of oral oestrogens, potentially reducing their effectiveness.
• Estrogen-containing medications may increase the risk of blood clots when taken with raloxifene.
• The risk of bleeding may increase when raloxifene is combined with anticoagulants like warfarin.
• Drugs that induce or inhibit CYP3A4 and CYP2D6 enzymes can affect raloxifene's metabolism, altering its effectiveness.
• Raloxifene may increase the concentration of drugs metabolized by CYP2D6, such as certain antidepressants and antipsychotics.
• Concomitant use with tamoxifen may decrease the effectiveness of both drugs.

Following are the food interactions for Raloxifene 60mg Tablet:

• Avoid consuming large amounts of grapefruit or grapefruit juice as it can affect the metabolism of Raloxifene, potentially increasing its levels in the body and the risk of side effects.
• Limit alcohol consumption as it may increase the risk of liver problems and blood clots, especially when combined with Raloxifene's effects on blood clotting.
• High-fat meals may slightly increase the absorption of Raloxifene, but this effect is not clinically significant and does not require any specific dietary adjustments.
• Avoid vitamin and mineral supplements that contain high amounts of vitamin E and beta-carotene, as Raloxifene may already increase their levels in the body.
• Calcium-rich foods like dairy products, leafy greens, and fortified foods can be beneficial, but high calcium intake should be monitored to prevent potential interactions.
• Maintain a balanced diet rich in fruits, vegetables, whole grains, and lean proteins to support overall health while taking Raloxifene.
• Avoid excessive caffeine intake, as it may interfere with the absorption of Raloxifene and potentially increase its metabolism.
• Always follow the dosage instructions provided by your healthcare professional, and inform them about any dietary concerns or changes.

Raloxifene 60mg Tablets should be stored in a cool and dry place, preferably at room temperature, away from direct exposure to sunlight and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. Avoid storing near heat-emitting appliances or in humid areas like bathrooms, as temperature and humidity fluctuations can impact the medication's effectiveness. Dispose of any unused or expired tablets responsibly; do not flush them or pour them down the drain. Consult your pharmacist or healthcare provider for appropriate disposal methods to ensure environmental safety. It is crucial to keep medications out of children's reach to prevent accidental consumption.

Following are the quick tips for Raloxifene 60mg Tablet:

• Take the tablet with a full glass of water, preferably after a meal.
• Consume the tablet whole without crushing or chewing for optimal absorption.
• Maintain a consistent schedule by taking the tablet at the same time each day.
• Avoid missing doses; if you miss a dose, take it as soon as you remember, but skip if it's almost time for the next dose.
• Do not take double doses to make up for a missed one.
• Inform your doctor about all medications you are taking to prevent potential drug interactions.
• Regularly monitor your health and report any unusual symptoms to your healthcare provider.