Oxicef-DS (250mg/5ml) 60ml Suspension

Cefixime 250mg syrup/suspension, a third-generation cephalosporin antibiotic, exerts its bactericidal effect by disrupting the synthesis of the bacterial cell wall. It selectively binds to and inhibits specific penicillin-binding proteins (PBPs) that are crucial for cross-linking peptidoglycan strands, a vital component of the bacterial cell wall. By inhibiting PBPs, Cefixime interferes with the final stages of cell wall synthesis, leading to the weakening and eventual rupture of the bacterial cell wall, resulting in cell lysis and death. This mechanism of action is particularly effective against a wide range of Gram-positive and Gram-negative bacteria, making Cefixime a valuable treatment option for various bacterial infections.

Cefixime 250mg

Cephalosporin antibiotic

Suspension

The following are the uses of Cefixime 250mg Syrup/Suspension:

• Used for treating bacterial infections such as bronchitis, pneumonia, and gonorrhea.
• Used for managing acute otitis media (middle ear infection) in children.
• Used for relieving symptoms of tonsillitis and pharyngitis.
• Effective for treating acute sinusitis.
• Used for addressing uncomplicated urinary tract infections.
• Provides relief from skin and soft tissue infections.
• Can be used for prophylaxis (prevention) in certain surgical procedures.

In the case of an overdose of Cefixime 250mg Syrup/Suspension, prompt medical attention is necessary. Symptoms may include nausea, vomiting, diarrhea, and abdominal pain. The severity of these symptoms can vary based on the amount ingested. It is crucial to contact a healthcare professional or a poison control center for guidance on managing the overdose, as they can provide specific instructions and recommendations for treatment and monitoring.

In the case of a missed dose of Cefixime 250mg Syrup/Suspension, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed, as they may recommend adjusting your dosage to ensure the medication's effectiveness.

To administer Cefixime 250mg Syrup/Suspension, shake the bottle vigorously, then accurately measure the prescribed dose using a measuring cup or oral syringe, and take it orally once or twice a day, as directed by your healthcare professional, with or without food, ensuring you follow the dosage instructions for your specific age and condition.

Here are the conditions or situations when Cefixime 250mg Syrup/Suspension should not be used:

• Do not use if the patient has a known allergy to Cefixime or any other cephalosporin antibiotics.
• Avoid in patients with a history of severe allergic reactions to penicillin, as cross-reactivity may occur.
• Not suitable for patients with severe kidney disease or impairment.
• Contraindicated in patients with a history of colitis or other severe gastrointestinal disorders.
• Should not be used in patients who are dehydrated or have limited access to fluids.
• Do not administer if the patient has a history of seizures or is at an increased risk of seizures.
• Not recommended for newborn babies, especially premature or low birth weight infants.
• Avoid in patients with a history of severe diarrhea or antibiotic-associated colitis.
• Do not use if the patient is currently taking or has recently taken other antibiotics without medical advice.

Here are the possible side effects of Cefixime 250mg Syrup/Suspension:

• Diarrhea or loose stools
• Nausea or vomiting
• Abdominal pain or discomfort
• Headache or dizziness
• Rash or itching (allergic reaction)
• Swelling of the face, tongue, or throat (severe allergic reaction)
• Difficulty breathing or wheezing (rare but serious allergic reaction)
• Jaundice (yellowing of the skin or eyes)
• Dark urine or pale stools (indicating liver issues)
• Unusual bleeding or bruising (indicating blood-related issues)
• Fungal infections, such as oral thrush, from prolonged use

Following are the precautions and warnings for Cefixime 250mg Syrup/Suspension:

• This medication should not be used if you are allergic to Cefixime or any other cephalosporin antibiotics.
• Patients with a history of gastrointestinal diseases, especially colitis, should use with caution and inform their doctor of any previous conditions.
• Cefixime may reduce the effectiveness of birth control pills, so alternative contraceptive methods are recommended during treatment.
• It is important to complete the full course of medication as prescribed, even if symptoms improve before completion.
• Cefixime should be used with caution in patients with kidney disease, as dosage adjustments may be necessary.
• This medication may cause diarrhea, and in some cases, it can be severe. If persistent diarrhea occurs, contact your doctor immediately.
• If you have a history of allergies, asthma, or kidney disease, inform your doctor before taking Cefixime.

Following are the drug interactions for Cefixime 250mg Syrup/Suspension:

• Probenecid can decrease the elimination of Cefixime, potentially increasing its levels and risk of side effects.
• Cefixime may reduce the effectiveness of oral contraceptives, requiring additional contraceptive measures.
• Antacids containing aluminum and magnesium can decrease the absorption of Cefixime when taken simultaneously.
• Concurrent use with nephrotoxic drugs (e.g., aminoglycosides, diuretics) may increase the risk of kidney damage.
• The effect of Cefixime may be reduced when taken with other antibiotics like Chloramphenicol.
• Cefixime can potentially affect the results of certain lab tests, including Coombs' test and glucose tests.
• It may decrease the effectiveness of live bacterial vaccines (e.g., typhoid vaccine), and separate administration is recommended.

Following are the food interactions to be aware of when taking Cefixime 250mg Syrup/Suspension:

• Avoid consuming alcohol during the treatment period as it may reduce the absorption of Cefixime and potentially decrease its effectiveness.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Cefixime, leading to increased drug levels in the body and a higher risk of side effects.
• Dairy products like milk, yogurt, or cheese can interfere with the absorption of Cefixime, so it is recommended to take the medication at least 1-2 hours before or after consuming these products.
• High-fat meals can delay the absorption of Cefixime, so it is advisable to take the medication on an empty stomach or at least 1 hour before a meal.
• Antacids containing aluminum or magnesium can reduce the absorption of Cefixime, so it is best to separate the intake of these medications by at least 2 hours.
• Vitamin and mineral supplements, particularly those containing iron, calcium, or zinc, can also interfere with Cefixime absorption, so maintain a gap of 2 hours between the medication and these supplements.
• Certain acidic foods like citrus fruits or juices may alter the pH of the stomach and potentially affect Cefixime absorption, so it's best to consume them at a different time than the medication.
• Caffeinated beverages like coffee or tea may increase the elimination of Cefixime from the body, so it's advisable to limit their consumption during treatment.

Cefixime 250mg Syrup/Suspension should be stored in a cool and dry place, preferably at room temperature, ensuring it is protected from direct sunlight and moisture. Keep the medication securely sealed in its original container to maintain its integrity and prevent contamination. Avoid exposing the syrup to temperature extremes by not storing it in bathrooms or near heat sources like ovens or radiators. Prioritize medication safety by regularly checking the expiration date, and if the syrup is unused or past its expiration, do not flush it or pour it down the drain. Consult your pharmacist or healthcare provider for safe disposal instructions to minimize environmental impact. Always keep medications out of children's reach to prevent accidental consumption.

Following are the quick tips for Cefixime 250mg Syrup/Suspension:

• Consult a doctor for the correct prescription and duration of treatment.
• Administer the prescribed dose using the provided measuring device.
• Ensure the medication is well-mixed by shaking the bottle before each use.
• Encourage patients to complete the full course of medication as prescribed.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Avoid using expired medication; check the expiration date before use.
• Inform your doctor about any allergies or medical conditions before starting this medication.
• Do not share this medication with others; individual medical needs may vary.