Oxidil (500mg) IV Injection

Ceftriaxone 500mg Injection** is a broad-spectrum antibiotic belonging to the cephalosporin class. It is used to treat a wide range of bacterial infections, including those of the respiratory tract, urinary tract, skin, soft tissue, bones, joints, and certain sexually transmitted infections like gonorrhea. This medication works by inhibiting bacterial cell wall synthesis, leading to the destruction of the bacteria. Ceftriaxone is administered via intramuscular or intravenous injection and is often prescribed when oral antibiotics are not suitable or effective. The dosage and duration depend on the severity of the infection and the patient's overall health. Common side effects may include pain at the injection site, diarrhea, rash, or nausea. It is important to use this medication under the guidance of a healthcare professional.

Ceftriaxone 500mg

third-generation cephalosporin

injection

Following are the uses of Ceftriaxone 500mg Injection:

• Treats respiratory tract infections, including pneumonia and bronchitis
• Addresses urinary tract infections caused by susceptible bacteria
• Treats skin and soft tissue infections such as cellulitis and abscesses
• Effective against bone and joint infections, including osteomyelitis
• Manages sexually transmitted infections, such as gonorrhea
• Treats bacterial meningitis by targeting the causative pathogens
• Used for abdominal infections like peritonitis and intra-abdominal abscesses
• Administered to prevent infections in surgical procedures (prophylaxis)
• Treats septicemia (bloodstream infections) caused by susceptible bacteria
• Addresses Lyme disease in its early and late stages when caused by Borrelia species

Dosage of Ceftriaxone 500mg Injection:

• For respiratory tract infections

• For urinary tract infections

• For skin and soft tissue infections

• For sexually transmitted infections like gonorrhea

• For bacterial meningitis

• For abdominal infections

• For surgical infection prophylaxis

• For septicemia

• For Lyme disease

In case of an overdose of Ceftriaxone 500mg Injection, it is important to seek immediate medical attention. Overdose symptoms may include nausea, vomiting, diarrhea, dizziness, or seizures. Since Ceftriaxone is administered by a healthcare professional, overdosing is rare. However, if it occurs, treatment typically involves supportive care and symptomatic management. Hemodialysis is not effective in removing ceftriaxone from the body, as it is highly protein-bound. Patients should be closely monitored for signs of toxicity, and appropriate interventions should be implemented as advised by a healthcare provider. Always ensure the medication is administered by qualified medical personnel to prevent overdose risks.

In case of a missed dose of Ceftriaxone 500mg Injection, it is important to inform your healthcare provider promptly. If it is close to the time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for the missed one, as this can increase the risk of side effects. Since Ceftriaxone is typically administered by a healthcare professional in a clinical setting, missed doses are less likely. However, if you are administering the injection at home, ensure you follow the prescribed schedule strictly and consult your doctor or pharmacist if you have any concerns.

Ceftriaxone 500mg Injection is administered by a healthcare professional as an intramuscular or intravenous injection. The dose and frequency depend on the type and severity of the infection, as well as the patient’s age, weight, and kidney function. For intramuscular use, it is typically diluted with a suitable diluent, such as lidocaine, to reduce injection site discomfort. For intravenous administration, it is diluted in sterile water or compatible IV fluids and infused over the prescribed duration. It is important to follow the doctor’s instructions and complete the full course of treatment, even if symptoms improve, to prevent antibiotic resistance. Always ensure the injection is given in a sterile environment by trained personnel.

When not to use Ceftriaxone 500mg Injection:

• If allergic to ceftriaxone, cephalosporins, or any of its components.
• In patients with a history of severe hypersensitivity to penicillin or other beta-lactam antibiotics.
• In newborns with hyperbilirubinemia (jaundice) or those requiring calcium-containing IV solutions, as it may cause precipitation in the lungs and kidneys.
• In patients with severe liver or kidney impairment without dose adjustment and close monitoring.
• If you have a known history of gallbladder or biliary sludge formation, as ceftriaxone may exacerbate these conditions.
• In premature infants or neonates under 41 weeks postmenstrual age (gestational + chronological age).
• If taking calcium-containing intravenous solutions concurrently, due to the risk of fatal precipitate formation.
• For treatment of infections caused by organisms resistant to ceftriaxone.

Side effects of Ceftriaxone 500mg Injection:

• Rash
• Diarrhea
• Nausea
• Vomiting
• Pain
• Fever
• Headache
• Dizziness
• Leukopenia
• Thrombophlebitis
• Allergies
• Jaundice

Precautions and Warnings for Ceftriaxone 500mg Injection include:

• Use with caution if you have a history of allergic reactions to ceftriaxone, cephalosporins, or any other ingredients in the injection.
• Avoid use in patients with severe liver or kidney impairment unless dose adjustment and monitoring are done by a healthcare provider.
• Use cautiously in individuals with a history of gastrointestinal disorders, such as colitis or gastrointestinal bleeding.
• Consult a doctor before use during pregnancy or breastfeeding to assess potential risks and benefits.
• Inform your doctor of any medications you are taking, especially those that may interact with ceftriaxone (e.g., warfarin, aminoglycosides, or calcium-containing intravenous solutions).
• Do not use in newborns with hyperbilirubinemia, as it may cause severe complications.
• Long-term use of ceftriaxone may increase the risk of gallbladder issues, so monitor for signs of gallstones or biliary sludge.
• Avoid sudden discontinuation without consulting a doctor, as it may lead to worsened infection.
• Store properly, keep out of reach of children, and prevent accidental injection.

Drug interactions of Ceftriaxone 500mg Injection include:

• Use cautiously with warfarin, as ceftriaxone may increase the risk of bleeding by affecting blood clotting factors.
• May interact with aminoglycoside antibiotics (e.g., gentamicin), increasing the risk of nephrotoxicity and ototoxicity.
• Can interact with calcium-containing intravenous solutions, potentially leading to precipitation in the lungs and kidneys, especially in neonates.
• Use with caution when combined with diuretics like furosemide, as it may increase the risk of renal dysfunction.
• May increase the effects of oral anticoagulants, such as warfarin, requiring close monitoring of coagulation parameters.
• Can reduce the effectiveness of certain vaccines, such as the typhoid vaccine, when taken together.
• Ceftriaxone may affect the pharmacokinetics of other drugs metabolized by the liver, so dose adjustments might be needed.

Food interactions of Ceftriaxone 500mg Injection include:

• Ceftriaxone can be administered with or without food, as food does not significantly affect its absorption or effectiveness.
• However, it is recommended to avoid consuming alcohol during treatment with ceftriaxone, as alcohol may increase the risk of certain side effects, such as nausea, vomiting, and headache.
• High-fat meals may slightly delay the absorption of ceftriaxone but do not affect its overall effectiveness.

Ceftriaxone 500mg Injection should be stored in a cool, dry place, away from direct sunlight and heat, at a temperature between 20°C to 25°C (68°F to 77°F). Keep the medication in its original packaging to protect it from moisture. Once reconstituted, the solution should be used immediately or within the timeframe specified by the healthcare provider or pharmacy. Any unused or expired medication should be properly disposed of by following local regulations or returning it to a pharmacy for safe disposal. Do not flush medications down the toilet or throw them in the trash unless instructed to do so. Always ensure that the injection is kept out of reach of children to prevent accidental ingestion.

Quick Tips for using Ceftriaxone 500mg Injection:

• Always use the injection as prescribed by your healthcare provider.
• The injection should be administered by a healthcare professional either intramuscularly or intravenously.
• Inform your doctor of any allergies to antibiotics, especially cephalosporins or penicillins, before using this medication.
• Avoid alcohol during treatment, as it may increase the risk of side effects such as nausea and vomiting.
• If you miss a dose, contact your healthcare provider for guidance on how to proceed.
• Monitor for any side effects such as rash, fever, or diarrhea, and report them to your healthcare provider.
• Ensure the injection is administered in a sterile environment to reduce the risk of infection.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.
• Keep out of reach of children to prevent accidental injection or ingestion.