OXSORALEN LOTION "LOCAL"

The mechanism of action of Methoxsalen Lotion primarily involves its ability to interact with DNA and ultraviolet (UV) light. Methoxsalen is a psoralen compound that intercalates into DNA, forming covalent bonds with pyrimidine bases. When the treated skin is exposed to UV light, typically UVA, the methoxsalen-DNA complex absorbs the energy from the UV radiation. This absorption triggers a photochemical reaction, generating reactive oxygen species (ROS) and causing DNA damage. The presence of methoxsalen enhances the cytotoxic effects of UV light, leading to the destruction of rapidly dividing cells, including certain types of skin cells and pathogens such as bacteria and fungi. By selectively targeting cells with high proliferative activity, methoxsalen lotion can be used in combination with controlled UV exposure to treat various skin conditions, making it an effective photochemotherapeutic agent.

Psoralen (topical).

Lotion

The following are the uses of Methoxsalen Lotion:

• Used for treating a skin condition called psoriasis, helping to reduce symptoms.
• Used for managing a type of skin cancer known as mycosis fungoides, providing targeted treatment.
• Used for alleviating symptoms of a rare disorder called vitiligo, where skin loses its color.
• Used for addressing certain skin issues related to cutaneous T-cell lymphoma, offering relief.
• Used for aiding in the treatment of severe, disabling psoriasis, offering an effective solution.
• Used for improving the appearance of skin in grafted areas, promoting better skin health.
• Used for treating skin reactions to radiation, offering relief and healing.
• Used for managing skin conditions that haven't responded to other therapies, as a specialized treatment option.

In the case of an overdose of Methoxsalen Lotion, it is important to recognize the potential severity of this situation. Skin reactions such as redness, blistering, or severe burning may occur. It is advisable to immediately seek medical advice and treatment to address any adverse effects. Prompt action can help mitigate the impact of an overdose and ensure appropriate care.

In the case of a missed dose of Methoxsalen Lotion, it is important to follow the instructions provided by your healthcare professional. If you forget to apply the lotion at the scheduled time, apply it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra lotion to make up for a missed dose, as this may increase the risk of side effects. Consult your healthcare provider if you have any concerns or questions regarding missed doses.

To apply Methoxsalen Lotion, thoroughly wash and dry the treatment area, then gently rub a thin layer of the lotion onto the skin, ensuring even coverage, and follow the prescribed treatment schedule provided by your healthcare professional.

Following are the conditions when Methoxsalen Lotion should not be used:

• Should not be used in individuals with a known hypersensitivity or allergy to Methoxsalen or any of the excipients in the lotion.
• Contraindicated in patients with a history of skin cancer or those who are at high risk of developing skin cancer.
• Not recommended for individuals with a history of severe sunburn reactions or extreme sensitivity to sunlight.
• Should be avoided in patients with systemic lupus erythematosus (SLE) as it can trigger a flare-up.
• Not suitable for use on children, especially infants, due to increased skin sensitivity.
• Should not be used on skin areas with open wounds, infections, or severe inflammation.
• Contraindicated in patients taking medications that increase photosensitivity, such as certain antibiotics and antidepressants.
• Avoid using if you have a history of porphyria, as it may cause a photosensitive reaction.

The side effects of Methoxsalen Lotion may include:

• Increased sensitivity to sunlight and UV rays.
• Skin redness, itching, or burning.
• Dryness or scaling of the skin.
• Darkening or lightening of the skin.
• Changes in skin pigmentation, including freckles or dark spots.
• Blistering or peeling skin.
• Severe sunburn or skin damage if used improperly.
• Eye irritation or temporary changes in vision.

Following are the precautions and warnings for Methoxsalen Lotion:

• Avoid excessive exposure to sunlight, including sunlamps and tanning beds, as this medication increases the skin's sensitivity to UV light.
• Wear protective clothing and use sunscreen when outdoors, even on cloudy days.
• Do not use this medication if you are pregnant or breastfeeding, as it may harm the fetus or infant.
• Keep the lotion away from eyes, mouth, and mucous membranes, and wash your hands thoroughly after application.
• Inform your doctor if you have a history of skin cancer, lupus, or any other skin conditions before using this medication.
• Discontinue use and seek medical attention if severe skin reactions, burning, or itching occur.
• This medication may make you more susceptible to sunburn, so avoid prolonged sun exposure and take extra precautions during treatment.

Following are the drug interactions for Methoxsalen Lotion:

• Methoxsalen can increase sensitivity to sunlight and UV light, so avoid using with other photosensitizing medications like thiazide diuretics, tetracyclines, and sulfonamides.
• The risk of skin reactions and burns is higher when used with other topical agents such as tretinoin, benzoyl peroxide, or salicylic acid.
• Concomitant use with St. John's Wort may reduce the effectiveness of Methoxsalen.
• Methoxsalen may decrease the effectiveness of hormonal contraceptives, including birth control pills, patches, or rings.
• It can interact with medications that affect the immune system, such as corticosteroids or immunosuppressants, potentially altering their effects.
• Avoid using with other treatments that increase skin sensitivity, like chemical peels or laser therapy, to prevent severe skin reactions.
• Consult a doctor if you are taking any medications that affect blood clotting, as Methoxsalen may influence their activity.

Following are the food interactions for Methoxsalen Lotion:

• Avoid excessive exposure to sunlight, including tanning beds and sunlamps. This medication increases the skin's sensitivity to UV rays, leading to severe sunburn.
• Grapefruit and grapefruit juice should be consumed with caution as they may increase the sensitivity of your skin to sunlight, enhancing the effects of Methoxsalen.
• Avoid eating St. John's Wort as it can increase skin sensitivity, potentially intensifying the effects of the medication.
• While on Methoxsalen, limit your caffeine intake, as it may contribute to dehydration and increase photosensitivity.
• Alcoholic beverages should be avoided as they can cause dehydration and potentially increase the skin's sensitivity to light, raising the risk of sunburn.
• Avoid consuming foods rich in vitamin A, such as liver, during treatment, as they can also enhance photosensitivity.
• Consult your healthcare provider about any specific dietary restrictions or recommendations while using Methoxsalen to ensure safe and effective treatment.

Methoxsalen Lotion should be stored with utmost care, ensuring it remains protected from direct sunlight and heat. Keep the lotion in its original container, tightly sealed, to maintain its integrity and prevent contamination. Maintain a cool, dry environment for storage, avoiding places like bathrooms or near heat-emitting appliances. Regularly check the expiration date, and dispose of expired or unused lotion responsibly; do not pour it down the drain or flush it. Consult your pharmacist for safe disposal practices. It is crucial to keep the medication away from children to prevent accidental exposure or ingestion. Responsible storage and disposal are essential to ensure the safety and effectiveness of Methoxsalen Lotion.

Following are the quick tips for Methoxsalen Lotion:

• Apply the lotion as directed by your dermatologist for the treatment of psoriasis or vitiligo.
• Ensure you are not allergic by performing a patch test on a small area of skin before full application.
• Use the lotion only on the affected areas as prescribed, avoiding healthy skin.
• Wear protective clothing and sunscreen when going outdoors after application to minimize sun sensitivity.
• Wash your hands thoroughly after applying the lotion to avoid accidental contact with eyes or mouth.
• Do not use this medication for prolonged periods without consulting your doctor.
• Store the lotion in a cool, dry place, away from direct sunlight and heat.