PAGASYS 180MG INJ (PEGINTERFERON)

PAGASYS 180MG INJ (PEGINTERFERON)

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  • Manufacturer IMPORTED
  • Generic Name PEGINTERFERON

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    The mechanism of action of PEGINTERFERON 180mg Injection involves its ability to mimic the biological effects of naturally occurring interferon. Interferons are proteins produced by the body's immune system in response to viral infections. PEGINTERFERON is a modified form of interferon alpha-2a, where polyethylene glycol (PEG) is attached to the interferon molecule. This modification increases the drug's half-life and slows its clearance from the body, allowing for less frequent dosing. Upon administration, PEGINTERFERON binds to specific cell surface receptors, triggering a cascade of intracellular signaling events. It induces the expression of various genes involved in antiviral responses, including those encoding enzymes that degrade viral RNA and proteins that inhibit viral replication. Additionally, it modulates the immune system by enhancing the activity of natural killer cells, macrophages, and T lymphocytes, thereby improving the body's ability to recognize and eliminate infected cells. The overall effect is a potent antiviral and immunomodulatory response, making PEGINTERFERON effective in treating certain viral infections and specific types of cancer.

  • Ingredients

    PEGINTERFERON
  • Drug Class

    Pegylated interferon

  • Dosage Form

    Injection

  • Uses

    The following are the uses of PEGINTERFERON 180MG Injection:

    • Used for treating chronic Hepatitis C, reducing viral load and improving liver health.
    • Used for managing chronic Hepatitis B infections, controlling viral replication.
    • Used in combination therapy for certain cancers like melanoma and renal cell carcinoma.
    • Used to stimulate the immune system in patients with specific cancers.
    • Effective in treating myeloproliferative disorders, reducing symptoms and spleen size.
    • Used for certain blood disorders, improving platelet counts and reducing symptoms.
    • Can be employed as an adjunct therapy for specific HIV treatments.
  • In case of Overdose

    In the case of an overdose of PEGINTERFERON 180MG Injection, it is important to recognize and address any potential side effects promptly. Seek medical advice if symptoms such as fatigue, fever, or flu-like symptoms persist or worsen. Severe reactions may require immediate medical intervention, including monitoring vital signs and providing supportive care. Quick action can help manage any adverse effects and ensure the patient's well-being.

  • Missed Dose

    In the case of a missed dose of PEGINTERFERON 180MG Injection, it is important to consult your healthcare provider for specific instructions. Generally, if the missed dose is discovered within a few hours of the scheduled time, it can be taken immediately. However, if it has been a longer period, it is best to skip the missed dose and continue with the next scheduled dose as directed. Never double the dose to make up for a missed one.

  • How To Use

    To administer PEGINTERFERON 180MG Injection, carefully follow the instructions provided by your healthcare professional inject the prescribed dose subcutaneously, ensuring the injection is given under the skin as directed, and follow the recommended dosage schedule for optimal effectiveness.

  • When Not to Use

    Following are the conditions or situations when PEGINTERFERON 180MG Injection should not be used:

    • Not recommended for individuals with a history of severe allergic reactions to peginterferon or any of its components.
    • Contraindicated in patients with severe depression or suicidal tendencies.
    • Should not be used in patients with severe liver disease or decompensated liver cirrhosis.
    • Not suitable for individuals with autoimmune hepatitis or a history of autoimmune disorders.
    • Avoid using in patients with severe kidney disease or end-stage renal disease.
    • Do not administer to patients with a history of severe heart disease or heart attack.
    • Contraindicated in pregnant or breastfeeding women.
    • Should not be used in children and adolescents under 18 years of age.
  • Side Effects

    The side effects of PEGINTERFERON 180MG Injection may include:

    • Fatigue and weakness
    • Flu-like symptoms such as fever, chills, and muscle/joint pain
    • Nausea and vomiting
    • Loss of appetite
    • Depression
    • Hair thinning or hair loss
    • Skin rashes or itching
    • Changes in liver function tests
  • Precautions & Warnings

    Following are the precautions and warnings for PEGINTERFERON 180MG Injection:

    • Not recommended for patients with a history of severe hypersensitivity reactions to PEGINTERFERON or any of its components.
    • Regular monitoring of blood cell counts, liver function, and thyroid function is essential during treatment.
    • Patients with a history of psychiatric disorders should be closely monitored for potential exacerbation of symptoms.
    • Caution is advised in patients with pre-existing cardiac disease as it may cause adverse cardiovascular effects.
    • Elderly patients may require dose adjustments and careful monitoring due to increased susceptibility to side effects.
    • Not recommended for use during pregnancy or breastfeeding unless the potential benefits outweigh the risks.
    • Patients should be advised to avoid driving or operating heavy machinery if they experience dizziness or other neurological side effects.
  • Drug Interactions

    Following are the drug interactions for PEGINTERFERON 180MG Injection:

    • Concomitant use with didanosine may increase the risk of pancreatitis and hepatic decompensation.
    • Thiopurine immunosuppressants (e.g., azathioprine, mercaptopurine) may increase the risk of myelosuppression when used with PEGINTERFERON.
    • PEGINTERFERON can enhance the anticoagulant effect of warfarin, requiring close monitoring of INR and dose adjustments.
    • Rifampin may decrease PEGINTERFERON concentrations, potentially reducing its effectiveness.
    • Drugs that suppress bone marrow, such as myelosuppressive antineoplastic agents, can increase the risk of severe myelosuppression when combined with PEGINTERFERON.
    • The risk of bradycardia may be elevated when used with beta-blockers or other bradycardia-inducing medications.
    • Caution is advised when combining PEGINTERFERON with other hepatotoxic agents, as it may increase the risk of hepatotoxicity.
  • Food Interactions

    Following are the food interactions for PEGINTERFERON 180MG Injection:

    • Avoid alcohol consumption during treatment as it may exacerbate the medication's side effects, especially liver-related issues.
    • Grapefruit and grapefruit juice should be consumed with caution as they may interfere with the medication's metabolism, potentially leading to increased side effects.
    • High-fat meals might affect the absorption of PEGINTERFERON, so it is advisable to maintain a consistent dietary pattern.
    • Caffeine intake should be monitored as it can interact with the medication, causing increased anxiety or nervousness.
    • Foods rich in tyramine, like aged cheeses, cured meats, and certain types of beer, should be avoided to prevent potential blood pressure issues.
    • It is recommended to maintain a well-balanced diet to support overall health and manage side effects effectively.
    • Stay hydrated by drinking plenty of fluids, especially water, to help manage potential dehydration and support kidney function.
    • Consult a healthcare professional for personalized dietary advice, especially if you have specific dietary restrictions or health conditions.
  • Storage/Disposal

    The storage and disposal of PEGINTERFERON 180MG Injection require specific attention to ensure its effectiveness and safety. Store the injection in a cool, dry place, preferably at room temperature, ensuring it remains protected from direct sunlight and moisture. Keep the medication in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Avoid exposing it to extreme temperatures, such as those near heat sources or in bathrooms, as this can impact its quality. Always check the expiration date, and if the medication is past its prime, dispose of it responsibly. Proper disposal methods should be followed, avoiding flushing or pouring it down the drain; instead, consult a pharmacist for guidance on safe disposal. Lastly, ensure the medication is kept securely away from children to prevent accidental consumption.

  • Quick Tips, if any

    Following are the quick tips for PEGINTERFERON 180MG Injection:

    • Ensure you receive this injection under medical supervision as per the prescribed dosage.
    • Inform your doctor if you have any allergies or medical conditions before administration.
    • Stay well-hydrated before and after the injection to aid in the medication's effectiveness.
    • Avoid missing doses; if you miss one, consult your doctor for further instructions.
    • Report any side effects, such as fever, chills, or injection site reactions, to your healthcare provider.
    • Do not reuse or share needles; dispose of them safely after use.
    • Store the injection as directed by your pharmacist, typically in a refrigerator.

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