PAINEZE TAB

Codeine, a weak opioid agonist, binds to mu-opioid receptors in the central nervous system, reducing the perception of pain signals. It also acts on the cough center in the medulla, suppressing the cough reflex. Paracetamol (acetaminophen) in this combination exhibits analgesic and antipyretic properties. It inhibits the synthesis of prostaglandins, which are involved in pain and inflammation signaling, leading to reduced pain perception and fever reduction. The combination of codeine and paracetamol provides synergistic analgesia, allowing for effective pain relief while potentially reducing the required dosage of each individual component.

Opioid analgesic, non-opioid analgesic.

Tablet

The following are the uses of Codeine 15 mg, Paracetamol [ 500 mg] Tablet:

• Used for relieving mild to moderate pain, such as headaches, toothaches, and postoperative pain.
• Used to reduce fever and manage pain associated with conditions like flu, colds, and minor injuries.
• Used to treat symptoms of upper respiratory tract infections, including sore throat and cough.
• Used for alleviating discomfort and inflammation related to arthritis, muscle strains, and sprains.
• Used to provide temporary relief from menstrual cramps and associated pain.
• Used as a post-vaccination analgesic to ease injection site pain and discomfort.
• Used in combination with other medications to manage more severe pain or chronic conditions as advised by a healthcare professional.

In the case of an overdose of Codeine 15 mg and Paracetamol 500 mg tablets, individuals may experience symptoms such as severe respiratory depression, cold and clammy skin, constricted pupils, and loss of consciousness. Prompt medical attention is necessary to manage these effects. Treatment for overdose may involve administering an opioid antagonist to reverse the effects of codeine and providing supportive care to address respiratory and circulatory issues. It is crucial to seek emergency medical help immediately if an overdose is suspected.

In the case of a missed dose of Codeine 15 mg, Paracetamol [500 mg] Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss several doses, contact your healthcare provider for advice on how to safely resume your medication regimen without compromising your treatment plan.

To take the Codeine 15 mg, Paracetamol [500 mg] Tablet, swallow the tablet whole with a glass of water, following the prescribed dosage instructions provided by your healthcare professional; it can be taken with or without food, but it is important to adhere to the recommended frequency and not exceed the prescribed dosage.

Here are the conditions and situations when Codeine 15 mg, Paracetamol 500 mg Tablet should not be used:

• Should not be used in individuals with a known allergy to codeine, paracetamol, or any other opioid medications.
• Contraindicated in patients with severe respiratory depression or asthma, as codeine can suppress breathing.
• Not suitable for individuals with acute or severe liver impairment, as it may worsen liver function.
• Should be avoided in patients with severe kidney disease or impairment.
• Must not be used in individuals who have recently consumed alcohol or are intoxicated.
• Contraindicated during breastfeeding, as codeine and paracetamol can pass into breast milk.
• Not recommended for children below a certain age (varies by country and medical guidelines).
• Should not be used in patients with a history of gastrointestinal obstruction or severe constipation.
• Avoid in patients with a history of head injury, increased intracranial pressure, or brain tumors.
• Not suitable for individuals with a history of seizures or conditions that increase seizure risk.
• Must be used with caution and may be contraindicated in patients with a history of substance abuse or addiction.

The side effects of Codeine 15 mg, Paracetamol 500 mg Tablet may include:

• Drowsiness or dizziness
• Nausea and vomiting
• Constipation
• Dry mouth
• Itching or rash
• Difficulty breathing or swallowing (rare)
• Confusion or hallucinations (rare)
• Allergic reactions (skin rash, itching, swelling, severe dizziness)

Following are the precautions and warnings for Codeine 15 mg, Paracetamol [500 mg] Tablet:

• This medication should be used with caution in patients with respiratory conditions such as asthma or chronic obstructive pulmonary disease (COPD), as it may cause breathing difficulties.
• Not recommended for children under 12 years of age due to the risk of respiratory depression.
• Elderly patients may be more sensitive to the effects of codeine and paracetamol, so dosage adjustments might be necessary.
• Patients with liver or kidney impairment should exercise caution and consult a healthcare professional before use.
• Avoid alcohol consumption while taking this medication as it may increase the risk of liver damage and enhance the sedative effects.
• Do not drive or operate heavy machinery until you know how this medication affects you, as it can cause dizziness and drowsiness.
• Inform your doctor if you have a history of gastrointestinal problems, as codeine may cause constipation or worsen existing conditions.
• Discontinue use and seek medical attention if you experience allergic reactions or severe side effects.

Following are the drug interactions for Codeine 15 mg, Paracetamol 500 mg Tablet:

• Alcohol and other central nervous system (CNS) depressants (e.g., benzodiazepines, barbiturates) can increase the risk of respiratory depression and sedation.
• Monoamine oxidase inhibitors (MAOIs) taken within 14 days can lead to serious, potentially fatal reactions, including serotonin syndrome.
• Codeine may increase the effects of other opioids, enhancing respiratory depression and sedation.
• Paracetamol can affect the international normalized ratio (INR) when used with warfarin, requiring closer monitoring.
• Carbamazepine, phenytoin, and other enzyme inducers may reduce the effectiveness of codeine.
• Serotonergic drugs like selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) can increase the risk of serotonin syndrome.
• Rifampicin and other enzyme inducers may reduce the effectiveness of paracetamol by increasing its metabolism.

Following are the food interactions for Codeine 15 mg, Paracetamol 500 mg Tablet:

• Alcohol should be avoided as it can increase the risk of liver damage and may enhance the sedative effects of codeine, leading to excessive drowsiness and impaired coordination.
• Grapefruit and grapefruit juice should be consumed with caution as they can inhibit liver enzymes, potentially affecting the metabolism of codeine and increasing its levels in the body.
• High-fat meals may slightly increase the absorption of paracetamol, but this effect is generally not clinically significant.
• Caffeine-containing foods and beverages should be limited as they may increase the metabolism of codeine, potentially reducing its effectiveness.
• Avoid consuming large amounts of foods rich in tyramine (aged cheeses, cured meats, fermented foods) as they may interact with monoamine oxidase inhibitors (MAOIs) and cause a dangerous spike in blood pressure.
• Avoid excessive consumption of foods rich in vitamin K (leafy greens, broccoli, Brussels sprouts) as they can interfere with the blood-thinning effects of warfarin, if it is taken concurrently.
• It's generally advised to follow a balanced diet and stay well-hydrated to support the body's overall health and aid in the medication's effectiveness.
• Always consult your healthcare provider for specific dietary recommendations and to discuss any potential food-drug interactions.

Codeine 15 mg, Paracetamol [500 mg] Tablets should be stored in a cool and dry place, preferably in their original container, at room temperature, ensuring protection from light and moisture. Maintain a consistent temperature, avoiding extreme heat or cold, as it can impact the medication's effectiveness. Always keep the tablets out of reach of children and pets to prevent accidental consumption. When disposing of unused or expired tablets, do not flush them down the toilet or throw them into the trash. Instead, follow local guidelines or consult a pharmacist for safe disposal methods to minimize environmental impact. Proper storage and disposal practices are crucial to maintain the integrity of the medication and ensure safety.

Following are the quick tips for Codeine 15 mg, Paracetamol [500 mg] Tablet:

• Ensure you have a prescription for this medication and follow your doctor's instructions.
• Take the tablet as directed, typically one tablet every 4-6 hours, but not more than 4 tablets in 24 hours.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Avoid alcohol consumption while taking this medication.
• Do not drive or operate heavy machinery until you know how this medicine affects you.
• Inform your doctor if you have any medical conditions, especially breathing problems or liver/kidney disease.
• Store the medication at room temperature, away from moisture and heat.